Prognostic impact of lymph node invasion levels in patients with bladder cancer undergoing radical cystectomy and pelvic lymphadenectomy

Ikeda,Junichi; Ohe,Chisato; Yoshida,Takashi; Nakamoto,Takahiro; Saito,Ryoichi; Tsuta,Koji; Kinoshita,Hidefumi

doi:10.3892/ol.2024.14650

Prognostic impact of lymph node invasion levels in patients with bladder cancer undergoing radical cystectomy and pelvic lymphadenectomy

Authors:
- Junichi Ikeda
- Chisato Ohe
- Takashi Yoshida
- Takahiro Nakamoto
- Ryoichi Saito
- Koji Tsuta
- Hidefumi Kinoshita
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Affiliations: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan, Department of Urology, Kyoto University, Kyoto 606‑8507, Japan, Department of Pathology, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
Published online on: August 29, 2024 https://doi.org/10.3892/ol.2024.14650
Article Number: 517

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Abstract

Extranodal extension in metastatic lymph nodes (LNs) is a poor prognostic factor in bladder cancer (BC). Furthermore, cancer invasion levels in sentinel LNs are associated with prognosis in melanoma. The present study aimed to evaluate the LN invasion level, defined as the extent of cancer invasion in anatomical and immunological LN substructures, and compare it with the pathological node (pN) stage of the tumor‑node‑metastasis staging system in BC. A total of 98 patients with BC who underwent radical cystectomy and pelvic lymphadenectomy were retrospectively assessed. The LN invasion level was classified as follows: Level 0, no cancer cell within the resected LNs; Level 1, cancer cells confined to intracapsular lymph vessels and subcapsular or transverse sinuses; Level 2, cancer cells infiltrating the cortex, paracortex or medulla; and Level 3, cancer cells infiltrating or beyond the LN capsule. The proportion of patients with Levels 0, 1, 2 and 3 was 70.4% (69/98), 8.2% (8/98), 14.3% (14/98) and 7.1% (7/98), respectively. Kaplan‑Meier survival curves of recurrence‑free survival (RFS), cancer‑specific survival (CSS) and overall survival (OS) with LN invasion levels better stratified outcome patient when using Levels 1‑3 compared with pN1‑3. In addition, LN invasion levels better predicted RFS, CSS and OS, in comparison with the pN stage (c‑index of 0.672 vs. 0.646, 0.688 vs. 0.665, and 0.702 vs. 0.661, respectively). Finally, multivariate analysis revealed that the predictive accuracy of the model integrating pathological tumor (pT) stage and LN invasion levels in RFS, CSS and OS was greater than that of the conventional model that included pT and pN stage (c‑index of 0.723 vs. 0.703, 0.710 vs. 0.694, and 0.725 vs. 0.692, respectively). In conclusion, the model with LN invasion levels accurately predicted the prognosis of patients with BC after radical cystectomy and pelvic lymphadenectomy.

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