Open Access

Impact of ACEI/ARB use on the survival of hypertensive patients with cancer: A meta‑analysis

  • Authors:
    • Yao Xiao
    • Xinlong Chen
    • Wancheng Li
    • Xin Li
    • Wence Zhou
  • View Affiliations

  • Published online on: September 5, 2024     https://doi.org/10.3892/ol.2024.14667
  • Article Number: 534
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiotensin‑converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensive drugs. However, the impact that the use of ACEI and ARB drugs will have on the survival of patients with hypertension and cancer is still unclear. Therefore, the present study aimed to investigate the effects of ACEI and ARB use on the survival of patients with cancer. The Embase, PubMed and Web of Science databases were used to systematically analyze the survival of hypertensive patients with cancer treated with ACEIs or ARBs. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the association between ACEI and ARB use and patient survival. The relationship between the survival of patients with certain types of cancer and ACEI and ARB use was evaluated using the calculated HRs. Patients with ovarian, pancreatic, prostate, hepatocellular, lung, esophageal, gastric, colon, nasopharyngeal, head and neck tumors, gallbladder and rectal cancers that used ACEI and ARB analogs had significantly increased survival times, except for patients with breast cancer (HR, 1.04; 95% CI, 0.90‑1.19; P<0.01) and uroepithelial carcinoma (HR, 1.15; 95% CI, 0.69‑1.94; P<0.01), who had significantly decreased survival times, when compared with patients who did not use these drugs. Analysis of the relationship between the use of ACEIs or ARBs alone or in combination on the overall survival of hypertensive patients with cancer demonstrated that the use of ACEIs alone (HR, 1.00; 95% CI, 0.93‑1.08; P<0.01) did not have a significant effect on the survival of these patients. By contrast, the survival time was increased in hypertensive patients with cancer who used either ARBs alone (HR, 0.89; 95% CI, 0.84‑0.94; P<0.01) or a combination of ACEIs and ARBs (HR, 0.84; 95% CI, 0.78‑0.91; P<0.01). The present meta‑analysis demonstrated the potential effects of ACEI and ARB use on the overall survival of patients with cancer. Therefore, investigation of the underlying mechanisms of action of ACEIs and ARBs, as well as the identification of specific groups of patients who may benefit from these interventions, could potentially lead to novel therapeutic options and improve the prognosis of patients with cancer in the future.
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November-2024
Volume 28 Issue 5

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Copy and paste a formatted citation
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Spandidos Publications style
Xiao Y, Chen X, Li W, Li X and Zhou W: Impact of ACEI/ARB use on the survival of hypertensive patients with cancer: A meta‑analysis. Oncol Lett 28: 534, 2024.
APA
Xiao, Y., Chen, X., Li, W., Li, X., & Zhou, W. (2024). Impact of ACEI/ARB use on the survival of hypertensive patients with cancer: A meta‑analysis. Oncology Letters, 28, 534. https://doi.org/10.3892/ol.2024.14667
MLA
Xiao, Y., Chen, X., Li, W., Li, X., Zhou, W."Impact of ACEI/ARB use on the survival of hypertensive patients with cancer: A meta‑analysis". Oncology Letters 28.5 (2024): 534.
Chicago
Xiao, Y., Chen, X., Li, W., Li, X., Zhou, W."Impact of ACEI/ARB use on the survival of hypertensive patients with cancer: A meta‑analysis". Oncology Letters 28, no. 5 (2024): 534. https://doi.org/10.3892/ol.2024.14667