Open Access

Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review)

  • Authors:
    • Tuya Wang
    • Jing Fu
    • Ye Huang
    • Chun Fu
  • View Affiliations

  • Published online on: October 15, 2024     https://doi.org/10.3892/ol.2024.14748
  • Article Number: 2
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adenomatous polyposis coli (APC) is widely recognized as a heavily mutated gene that suppresses tumor growth in colorectal cancer (CRC). Its mutation is considered to be the primary and early event that occurs in the development of CRC. In addition, APC has a crucial role in inhibiting the canonical Wnt signaling pathway. APC mutations in CRC result in the production of shortened gene products. This impairment of β‑catenin destruction complexes causes an accumulation of active β‑catenin in the cytoplasm and nucleus. In these compartments, β‑catenin can bind with DNA‑binding proteins of the transcription factor/lymphoid enhancer‑binding factor family, thereby activating the Wnt signaling pathway. Consequently, the balance of numerous cellular processes is disrupted, ultimately driving the formation of tumors. There is a growing body of evidence indicating the prevalent occurrence of APC truncation in the majority of CRC cases. Furthermore, it has been observed that these truncated proteins have a crucial role in the activation of the Wnt signaling pathway and the subsequent loss of tumor inhibitory function. This review aimed to provide an overview of the recent advancements in understanding the mechanism behind APC truncation and its association with the onset and progression of CRC.
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January-2025
Volume 29 Issue 1

Print ISSN: 1792-1074
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Spandidos Publications style
Wang T, Fu J, Huang Y and Fu C: Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review). Oncol Lett 29: 2, 2025.
APA
Wang, T., Fu, J., Huang, Y., & Fu, C. (2025). Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review). Oncology Letters, 29, 2. https://doi.org/10.3892/ol.2024.14748
MLA
Wang, T., Fu, J., Huang, Y., Fu, C."Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review)". Oncology Letters 29.1 (2025): 2.
Chicago
Wang, T., Fu, J., Huang, Y., Fu, C."Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review)". Oncology Letters 29, no. 1 (2025): 2. https://doi.org/10.3892/ol.2024.14748