Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells

  • Authors:
    • Mehmet R. Topçul
    • İdil Çetin
    • Ercan Pulat
    • Mahmut Çalişkan
  • View Affiliations

  • Published online on: November 1, 2024     https://doi.org/10.3892/ol.2024.14784
  • Article Number: 38
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Abstract

In recent years, there have been significant developments using combined therapies in cancer treatment. The present study aimed to determine the effects of using crizotinib alone and in combination with butyric acid on different types of breast cancer cells. A total of three different breast cancer models were used: MDA‑MB‑231, a triple negative model; MCF‑7, a Luminal A model; and SKBR‑3 cell line, a human epidermal growth factor receptor 2 positive model. In the experiments, proliferation rates and cell index values were obtained using the xCELLigence RTCA DP System, and mitotic index, bromodeoxyuridine labeling index and caspase activity were evaluated as cell kinetics parameters. The results showed that while proliferation rates, cell index values, mitotic index and bromodeoxyuridine labeling index decreased, caspase activity values increased. These results demonstrated that the combined application was more effective than the monotherapy application and could be used at lower concentrations than those drugs applied as monotherapy.
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January-2025
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Spandidos Publications style
Topçul MR, Çetin I, Pulat E and Çalişkan M: Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells. Oncol Lett 29: 38, 2025.
APA
Topçul, M.R., Çetin, I., Pulat, E., & Çalişkan, M. (2025). Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells. Oncology Letters, 29, 38. https://doi.org/10.3892/ol.2024.14784
MLA
Topçul, M. R., Çetin, I., Pulat, E., Çalişkan, M."Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells". Oncology Letters 29.1 (2025): 38.
Chicago
Topçul, M. R., Çetin, I., Pulat, E., Çalişkan, M."Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells". Oncology Letters 29, no. 1 (2025): 38. https://doi.org/10.3892/ol.2024.14784