Open Access

Skin metastasis of papillary thyroid carcinoma: A case report and literature review

  • Authors:
    • Haidi Chu
    • Dong Wang
    • Yanqing Qu
  • View Affiliations

  • Published online on: November 5, 2024     https://doi.org/10.3892/ol.2024.14789
  • Article Number: 43
  • Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study reports a rare case of skin metastasis in a 26‑year‑old female patient with a history of PTC positive for the BRAFV600E mutation. During the 2.5‑year follow‑up period after the initial surgical treatment of PTC, no evidence of distant metastasis was found via thyroglobulin measurements, neck ultrasound, or neck and chest computed tomography. However, following this period, the patient reported two skin nodules on the left side of the neck. Ultrasound‑guided punch biopsy was performed, and the pathology results demonstrated that the patient had skin metastases from the PTC. The patient received surgical resection and complete removal of nodules, and was subsequently discharged from the hospital. A literature review showed that there are numerous potential mechanisms for skin metastasis, and the treatments are diverse and dependent on the patient condition. While surgical treatment may effectively improve patient symptoms and prognosis, long‑term surveillance for recurrence is recommended for high‑risk cases. Skin metastasis of PTC should be suspected in patients who develop an upper body skin lesion with a history of PTC, even without evidence of disease metastasis. For high‑risk patients with skin metastasis of PTC with BRAF and TERT gene mutations, long‑term surveillance for recurrence should be recommended in cases with a poor prognosis, and further research of these cases should be conducted in the future to optimize surgical and medical care.
View Figures
View References

Related Articles

Journal Cover

January-2025
Volume 29 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chu H, Wang D and Qu Y: Skin metastasis of papillary thyroid carcinoma: A case report and literature review. Oncol Lett 29: 43, 2025.
APA
Chu, H., Wang, D., & Qu, Y. (2025). Skin metastasis of papillary thyroid carcinoma: A case report and literature review. Oncology Letters, 29, 43. https://doi.org/10.3892/ol.2024.14789
MLA
Chu, H., Wang, D., Qu, Y."Skin metastasis of papillary thyroid carcinoma: A case report and literature review". Oncology Letters 29.1 (2025): 43.
Chicago
Chu, H., Wang, D., Qu, Y."Skin metastasis of papillary thyroid carcinoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 43. https://doi.org/10.3892/ol.2024.14789