Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report

Kimura,Taku; Sakata,Ken-Ichiro; Ohga,Noritaka; Sato,Jun; Itagaki,Tatsuki; Munekata,Takeshi; Yanagawa‑Matsuda,Aya; Maeda,Taku; Hojo,Masahiro; Hatanaka,Kanako C.; Hatanaka,Yutaka; Iizasa,Hisashi

doi:10.3892/ol.2024.14798

Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report

Authors:
- Taku Kimura
- Ken-Ichiro Sakata
- Noritaka Ohga
- Jun Sato
- Tatsuki Itagaki
- Takeshi Munekata
- Aya Yanagawa‑Matsuda
- Taku Maeda
- Masahiro Hojo
- Kanako C. Hatanaka
- Yutaka Hatanaka
- Hisashi Iizasa
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Affiliations: Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido 060‑8586, Japan, Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido 060‑8586, Japan, Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060‑8648, Japan, Center for Development of Advanced Diagnostics, Hokkaido University Hospital, Sapporo, Hokkaido 060‑8648, Japan, Department of Microbiology, Faculty of Medicine, Shimane University, Izumo, Shimane 693‑8501, Japan
Published online on: November 11, 2024 https://doi.org/10.3892/ol.2024.14798
Article Number: 52
Copyright: © Kimura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The global prevalence of oral squamous cell carcinoma (OSCC) has been increasing. OSCC at the advanced stage tends to resist conventional treatment and causes local recurrence and distant metastasis, resulting in poor prognosis. Therefore, detecting this cancer at an early stage and performing early intervention are important. Promising biomarkers to detect OSCC have yet to be established; however, microRNAs (miRNAs/miRs) serve a crucial role in OSCC tumorigenesis and may be potential biomarkers. In the present case report, the availability of salivary miRNAs as a therapeutic and prognostic marker for patients with OSCC was assessed. The patient was a 33‑year‑old woman who was diagnosed with advanced OSCC of the tongue, and their miRNA profile isolated from a saliva sample at each clinical course was evaluated. Microarray analysis of the salivary samples revealed changes in the levels of four miRNAs (hsa‑miR‑6798‑5p, miR‑6803‑5p, miR‑6805‑5p and miR‑6845‑5p) in accordance with the clinical course. Neoadjuvant chemotherapy and surgical procedure decreased the levels, whereas the levels increased when the patient was diagnosed with lung metastasis. Furthermore, tongue and lung metastatic lesion specimens exhibited expression of the vascular endothelial growth factor receptor‑2, which is regulated by the four miRNAs. Accordingly, the present report proposed that salivary miRNAs could be a therapeutic and prognostic biomarker for OSCC.

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