Open Access

Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report

  • Authors:
    • Taku Kimura
    • Ken-Ichiro Sakata
    • Noritaka Ohga
    • Jun Sato
    • Tatsuki Itagaki
    • Takeshi Munekata
    • Aya Yanagawa‑Matsuda
    • Taku Maeda
    • Masahiro Hojo
    • Kanako C. Hatanaka
    • Yutaka Hatanaka
    • Hisashi Iizasa
  • View Affiliations

  • Published online on: November 11, 2024     https://doi.org/10.3892/ol.2024.14798
  • Article Number: 52
  • Copyright: © Kimura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The global prevalence of oral squamous cell carcinoma (OSCC) has been increasing. OSCC at the advanced stage tends to resist conventional treatment and causes local recurrence and distant metastasis, resulting in poor prognosis. Therefore, detecting this cancer at an early stage and performing early intervention are important. Promising biomarkers to detect OSCC have yet to be established; however, microRNAs (miRNAs/miRs) serve a crucial role in OSCC tumorigenesis and may be potential biomarkers. In the present case report, the availability of salivary miRNAs as a therapeutic and prognostic marker for patients with OSCC was assessed. The patient was a 33‑year‑old woman who was diagnosed with advanced OSCC of the tongue, and their miRNA profile isolated from a saliva sample at each clinical course was evaluated. Microarray analysis of the salivary samples revealed changes in the levels of four miRNAs (hsa‑miR‑6798‑5p, miR‑6803‑5p, miR‑6805‑5p and miR‑6845‑5p) in accordance with the clinical course. Neoadjuvant chemotherapy and surgical procedure decreased the levels, whereas the levels increased when the patient was diagnosed with lung metastasis. Furthermore, tongue and lung metastatic lesion specimens exhibited expression of the vascular endothelial growth factor receptor‑2, which is regulated by the four miRNAs. Accordingly, the present report proposed that salivary miRNAs could be a therapeutic and prognostic biomarker for OSCC.

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January-2025
Volume 29 Issue 1

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Spandidos Publications style
Kimura T, Sakata K, Ohga N, Sato J, Itagaki T, Munekata T, Yanagawa‑Matsuda A, Maeda T, Hojo M, Hatanaka KC, Hatanaka KC, et al: Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report. Oncol Lett 29: 52, 2025.
APA
Kimura, T., Sakata, K., Ohga, N., Sato, J., Itagaki, T., Munekata, T. ... Iizasa, H. (2025). Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report. Oncology Letters, 29, 52. https://doi.org/10.3892/ol.2024.14798
MLA
Kimura, T., Sakata, K., Ohga, N., Sato, J., Itagaki, T., Munekata, T., Yanagawa‑Matsuda, A., Maeda, T., Hojo, M., Hatanaka, K. C., Hatanaka, Y., Iizasa, H."Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report". Oncology Letters 29.1 (2025): 52.
Chicago
Kimura, T., Sakata, K., Ohga, N., Sato, J., Itagaki, T., Munekata, T., Yanagawa‑Matsuda, A., Maeda, T., Hojo, M., Hatanaka, K. C., Hatanaka, Y., Iizasa, H."Salivary miRNAs as a novel therapeutic marker in a patient with advanced oral squamous cell carcinoma: A case report". Oncology Letters 29, no. 1 (2025): 52. https://doi.org/10.3892/ol.2024.14798