Open Access

Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases

  • Authors:
    • Wenzhi Cai
    • Yutong Lu
    • Haiju He
    • Jiaqi Li
    • Shuangzhu Liu
    • Hongzhi Geng
    • Qin Yang
    • Liangyu Zeng
    • Depei Wu
    • Caixia Li
  • View Affiliations

  • Published online on: November 22, 2024     https://doi.org/10.3892/ol.2024.14817
  • Article Number: 71
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chimeric antigen receptor (CAR) T‑cell therapy is an effective treatment for diffuse large B‑cell lymphoma (DLBCL). However, it may activate the systemic immune system of the patient, resulting in cytokine release syndrome (CRS). Emapalumab is a human monoclonal antibody targeting interferon‑γ, inhibiting its interaction with cell surface receptors and the subsequent activation of inflammatory pathways. The present report describes the cases of 2 patients with relapsed DLBCL treated with CAR T‑cell therapy, in which the severe CRS associated with CAR T‑cell therapy was attenuated without compromising antitumor efficacy after receiving emapalumab. Further prospective clinical trials are warranted to determine the role of emapalumab in CAR T‑cell therapy.
View Figures
View References

Related Articles

Journal Cover

February-2025
Volume 29 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cai W, Lu Y, He H, Li J, Liu S, Geng H, Yang Q, Zeng L, Wu D, Li C, Li C, et al: Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncol Lett 29: 71, 2025.
APA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H. ... Li, C. (2025). Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases. Oncology Letters, 29, 71. https://doi.org/10.3892/ol.2024.14817
MLA
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29.2 (2025): 71.
Chicago
Cai, W., Lu, Y., He, H., Li, J., Liu, S., Geng, H., Yang, Q., Zeng, L., Wu, D., Li, C."Efficacy of emapalumab in the management of anti‑CD19 chimeric antigen receptor T‑cell therapy‑associated cytokine release syndrome: A report of two cases". Oncology Letters 29, no. 2 (2025): 71. https://doi.org/10.3892/ol.2024.14817