Open Access

Antitumor effects of plasma‑activated solution on a murine melanoma model in vivo and in vitro

  • Authors:
    • Xingyu Yang
    • Cheng Chen
    • Shiyun Zhou
    • Miaomiao Ren
    • Chenchen Zhang
    • Cheng Cheng
    • Chunjun Yang
  • View Affiliations

  • Published online on: November 26, 2024     https://doi.org/10.3892/ol.2024.14821
  • Article Number: 75
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is a common malignant skin tumor with highly invasive features and a high metastasis rate that can be difficult to treat clinically. Large‑scale resection of primary cutaneous melanoma is often used to avoid postoperative recurrence. For advanced patients, radiotherapy, targeted therapy and immunotherapy are often needed. Low‑temperature plasma has been proved to have significant antitumor effects on a variety of cancer cell lines cultured in vitro. The main limitation of direct low‑temperature plasma treatment is that it has weak penetration ability and can only treat superficial lesions. In recent years, research on low‑temperature plasma‑activated solution has revealed that it also have good antitumor effects and low‑temperature plasma penetration depth problems can be solved by local injection. The present study revealed that low‑temperature plasma‑activated phosphate buffer solution exhibited good antitumor effects and biosafety against melanoma in vitro and in vivo. It demonstrated that low‑temperature plasma‑activated solution has antitumor effects due to its regulation of intracellular redox, destruction of mitochondrial function and DNA damage. In vivo experiments demonstrated that treatment with low‑temperature plasma‑activated solution not only exhibited antitumor effects but also caused no significant damage to hematopoietic function or liver and kidney functions in mice. All these results demonstrated that low‑temperature plasma‑activated solution represent a promising antitumor treatment strategy.
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February-2025
Volume 29 Issue 2

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Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang X, Chen C, Zhou S, Ren M, Zhang C, Cheng C and Yang C: Antitumor effects of plasma‑activated solution on a murine melanoma model <em>in vivo</em> and <em>in vitro</em>. Oncol Lett 29: 75, 2025.
APA
Yang, X., Chen, C., Zhou, S., Ren, M., Zhang, C., Cheng, C., & Yang, C. (2025). Antitumor effects of plasma‑activated solution on a murine melanoma model <em>in vivo</em> and <em>in vitro</em>. Oncology Letters, 29, 75. https://doi.org/10.3892/ol.2024.14821
MLA
Yang, X., Chen, C., Zhou, S., Ren, M., Zhang, C., Cheng, C., Yang, C."Antitumor effects of plasma‑activated solution on a murine melanoma model <em>in vivo</em> and <em>in vitro</em>". Oncology Letters 29.2 (2025): 75.
Chicago
Yang, X., Chen, C., Zhou, S., Ren, M., Zhang, C., Cheng, C., Yang, C."Antitumor effects of plasma‑activated solution on a murine melanoma model <em>in vivo</em> and <em>in vitro</em>". Oncology Letters 29, no. 2 (2025): 75. https://doi.org/10.3892/ol.2024.14821