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Article Open Access

Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer

  • Authors:
    • Chenglong He
    • Wenjing Dong
    • Yanhua Lyu
    • Yan Qin
    • Siquan Zhong
    • Xiaomei Jiang
    • Jianjun Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Zhongshan City People's Hospital, Zhongshan, Guangdong 528403, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 89
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    Published online on: December 5, 2024
       https://doi.org/10.3892/ol.2024.14835
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Abstract

Colorectal cancer (CRC) is a malignant tumor with poor prognosis. Pyroptosis is a newly discovered type of programmed cell death that is typically accompanied by a strong inflammatory response. Accumulating evidence suggests that pyroptosis‑related genes (PRGs) may have important roles in the development of malignant tumors. However, the association between PRG expression and clinical outcomes in CRC remain unclear. In the present study, the genetic variations and transcriptional patterns of 52 PRGs were comprehensively analyzed using cohorts from The Cancer Genome Atlas and Gene Expression Omnibus and the mRNA expression levels of 7 PRGs in collected CRC samples were validated using reverse transcription‑quantitative PCR. Using LASSO‑Cox analysis, a PRG score was then generated and the relationship between the PRG score and prognosis, immune cell infiltration and drug sensitivity in CRC was uncovered. In the present study, the mutation and expression patterns of PRGs were analyzed and it was found that these genes were differentially expressed in CRC tissues compared with normal tissues. Based on the expression patterns of the PRGs, patients with CRC were divided into two subtypes (cluster A and B), of which cluster B had an improved prognosis and a higher abundance of immune cells. Next, differentially expressed genes between clusters A and B were identified and a PRG risk score closely related to the prognosis of CRC was constructed. Then, a nomogram for evaluating the overall survival of patients was constructed. Furthermore, a low PRG risk score was characterized by immune activation and closely related to the microsatellite instability‑high pattern. Additionally, the PRG risk score was notably correlated with drug sensitivity. In conclusion, the mutation and expression characteristics of PRGs in CRC were comprehensively analyzed and a prognostic PRG signature was constructed in the present study. This signature may predict immune cell infiltration and therapeutic response in CRC, providing new insights into the prognosis and treatment of CRC.
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View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Wang L, Lo CH, He X, Hang D, Wang M, Wu K, Chan AT, Ogino S, Giovannucci EL and Song M: Risk factor profiles differ for cancers of different regions of the colorectum. Gastroenterology. 159:241–256.e13. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Cree IA, Indave Ruiz BI, Zavadil J, McKay J, Olivier M, Kozlakidis Z, Lazar AJ, Hyde C, Holdenrieder S, Hastings R, et al: The international collaboration for cancer classification and research. Int J Cancer. 148:560–571. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Beck DE: Surgical management of colon and rectal cancer. Ochsner J. 4:156–162. 2002.PubMed/NCBI

5 

Cremolini C, Loupakis F, Antoniotti C, Lupi C, Sensi E, Lonardi S, Mezi S, Tomasello G, Ronzoni M, Zaniboni A, et al: FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: Updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study. Lancet Oncol. 16:1306–1315. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kastrinos F, Kupfer SS and Gupta S: Colorectal cancer risk assessment and precision approaches to screening: Brave new world or worlds apart? Gastroenterology. 164:812–827. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Tanaka Y, Masuda T, Mukoyama S, Yasuda S, Tajima T, Makuuchi H and Murayama C: Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years. Hepatogastroenterology. 50:1362–1366. 2003.PubMed/NCBI

8 

Fakih GM: Metastatic colorectal cancer: Current state and future directions. J Clin Oncol. 33:1809–1824. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Sepulveda AR, Hamilton SR, Allegra CJ, Grody W, Cushman-Vokoun AM, Funkhouser WK, Kopetz SE, Lieu C, Lindor NM, Minsky BD, et al: Molecular biomarkers for the evaluation of colorectal cancer: Guideline from the American society for clinical pathology, college of American pathologists, association for molecular pathology, and American society of clinical oncology. J Mol Diagn. 19:187–225. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K and Shao F: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 547:99–103. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Fink SL and Cookson BT: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 8:1812–1825. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC and Shao F: Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 535:111–116. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F and Shao F: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 526:660–665. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Al Mamun A, Mimi AA, Aziz MA, Zaeem M, Ahmed T, Munir F and Xiao J: Role of pyroptosis in cancer and its therapeutic regulation. Eur J Pharmacol. 910:1744442021. View Article : Google Scholar : PubMed/NCBI

15 

Tan G, Huang C, Chen J and Zhi F: HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway. J Hematol Oncol. 13:1492020. View Article : Google Scholar : PubMed/NCBI

16 

Tang Z, Ji L, Han M, Xie J, Zhong F, Zhang X, Su Q, Yang Z, Liu Z, Gao H and Jiang G: Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer. Life Sci. 257:1180652020. View Article : Google Scholar : PubMed/NCBI

17 

Guo J, Zheng J, Mu M, Chen Z, Xu Z, Zhao C, Yang K, Qin X, Sun X and Yu J: GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis. Biochem Biophys Res Commun. 548:60–66. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Jensen MA and Zenklusen JC: A practical guide to the cancer genome atlas (TCGA). Methods Mol Biol. 1418:111–141. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, et al: Gene expression classification of colon cancer into molecular subtypes: Characterization, validation, and prognostic value. PLoS Med. 10:e10014532013. View Article : Google Scholar : PubMed/NCBI

20 

Karki R and Kanneganti TD: Diverging inflammasome signals in tumorigenesis and potential targeting. Nat Rev Cancer. 19:197–214. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Wang B and Yin Q: AIM2 inflammasome activation and regulation: A structural perspective. J Struct Biol. 200:279–282. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Man SM and Kanneganti TD: Regulation of inflammasome activation. Immunol Rev. 265:6–21. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Hartigan JA and Wong MA: Algorithm AS 136: A K-means clustering algorithm. J R Stat Soc C (Appl Stat). 28:100–108. 1979.

24 

Wilkerson MD and Hayes DN: ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking. Bioinformatics. 26:1572–1573. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Yao H, Wu H and Liu Y: Improvement of prognostic and predictive network of colorectal cancer based upon the 8th edition of AJCC colorectal cancer staging system. Zhonghua Wei Chang Wai Ke Za Zhi. 20:24–27. 2017.(In Chinese). PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Hänzelmann S, Castelo R and Guinney J: GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14:72013. View Article : Google Scholar : PubMed/NCBI

28 

Charoentong P, Angelova M, Efremova M, Gallasch R, Hackl H, Galon J and Trajanoski Z: Bioinformatics for cancer immunology and immunotherapy. Cancer Immunol Immunother. 61:1885–1903. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G and Zitvogel L: Targeting the tumor microenvironment: Removing obstruction to anticancer immune responses and immunotherapy. Ann Oncol. 27:1482–1492. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Cristescu R, Mogg R, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu XQ, Lu H, Nebozhyn M, et al: Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy. Science. 362:eaar35932018. View Article : Google Scholar : PubMed/NCBI

32 

Asaoka Y, Ijichi H and Koike K: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 373:19792015. View Article : Google Scholar : PubMed/NCBI

33 

Overman MJ, McDermott R, Leach JL, Lonardi S, Lenz HJ, Morse MA, Desai J, Hill A, Axelson M, Moss RA, et al: Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): An open-label, multicentre, phase 2 study. Lancet Oncol. 18:1182–1191. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Chénard-Poirier M and Smyth EC: Immune checkpoint inhibitors in the treatment of gastroesophageal cancer. Drugs. 79:1–10. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell. 61:759–767. 1990. View Article : Google Scholar : PubMed/NCBI

37 

Ewing I, Hurley JJ, Josephides E and Millar A: The molecular genetics of colorectal cancer. Frontline Gastroenterol. 5:26–30. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J and Hu J: The role of pyroptosis in cancer: Pro-cancer or pro-‘host’? Cell Death Dis. 10:6502019. View Article : Google Scholar : PubMed/NCBI

39 

Wei Q, Zhu R, Zhu J, Zhao R and Li M: E2-induced activation of the NLRP3 inflammasome triggers pyroptosis and inhibits autophagy in HCC cells. Oncol Res. 27:827–834. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, et al: Gasdermin C is upregulated by inactivation of transforming growth factor β receptor type II in the presence of mutated Apc, promoting colorectal cancer proliferation. Plos One. 11:e01664222016. View Article : Google Scholar : PubMed/NCBI

41 

Loveless R, Bloomquist R and Teng Y: Pyroptosis at the forefront of anticancer immunity. J Exp Clin Cancer Res. 40:2642021. View Article : Google Scholar : PubMed/NCBI

42 

Qian BZ and Pollard JW: Macrophage diversity enhances tumor progression and metastasis. Cell. 141:39–51. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Schlößer HA, Theurich S, Shimabukuro-Vornhagen A, Holtick U, Stippel DL and von Bergwelt-Baildon M: Overcoming tumor-mediated immunosuppression. Immunotherapy. 6:973–988. 2014. View Article : Google Scholar

44 

Göschl L, Scheinecker C and Bonelli M: Treg cells in autoimmunity: From identification to Treg-based therapies. Semin Immunopathol. 41:301–314. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Van der Jeught K, Xu HC, Li YJ, Lu XB and Ji G: Drug resistance and new therapies in colorectal cancer. World J Gastroenterol. 24:3834–3848. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Wang TL, Diaz LA Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IeM, et al: Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci USA. 101:3089–3094. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Zheng C and Tan Z: A novel identified pyroptosis-related prognostic signature of colorectal cancer. Math Biosci Eng. 18:8783–8796. 2021. View Article : Google Scholar : PubMed/NCBI

48 

Li R, Zhang S and Liu G: Identification and validation of a pyroptosis-related prognostic model for colorectal cancer. Funct Integr Genomics. 23:212022. View Article : Google Scholar : PubMed/NCBI

49 

Chen M, Zhang J, Lin X, Zhu X and Xie T: A pyroptosis-related prognosis model to predict survival in colorectal cancer patients. Int J Clin Exp Pathol. 15:168–182. 2022.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He C, Dong W, Lyu Y, Qin Y, Zhong S, Jiang X and Xiao J: Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer. Oncol Lett 29: 89, 2025.
APA
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., & Xiao, J. (2025). Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer. Oncology Letters, 29, 89. https://doi.org/10.3892/ol.2024.14835
MLA
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., Xiao, J."Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer". Oncology Letters 29.2 (2025): 89.
Chicago
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., Xiao, J."Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer". Oncology Letters 29, no. 2 (2025): 89. https://doi.org/10.3892/ol.2024.14835
Copy and paste a formatted citation
x
Spandidos Publications style
He C, Dong W, Lyu Y, Qin Y, Zhong S, Jiang X and Xiao J: Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer. Oncol Lett 29: 89, 2025.
APA
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., & Xiao, J. (2025). Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer. Oncology Letters, 29, 89. https://doi.org/10.3892/ol.2024.14835
MLA
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., Xiao, J."Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer". Oncology Letters 29.2 (2025): 89.
Chicago
He, C., Dong, W., Lyu, Y., Qin, Y., Zhong, S., Jiang, X., Xiao, J."Molecular characteristics, clinical significance and cancer‑immune interactions of pyroptosis‑related genes in colorectal cancer". Oncology Letters 29, no. 2 (2025): 89. https://doi.org/10.3892/ol.2024.14835
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