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Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue

  • Authors:
    • Hui Luo
    • Yue-Qin Gou
    • Yue-Su Wang
    • Hui-Lin Qin
    • Hai-Ying Zhou
    • Xiao-Ming Zhang
    • Tian-Wu Chen

  • View Affiliations

  • Published online on: December 10, 2024     https://doi.org/10.3892/ol.2024.14843
  • Article Number: 97

  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paracancerous tissues actively communicate with the tumor and undergo molecular alterations associated with tumorigenesis. Apparent diffusion coefficient (ADC) can help distinguish between rectal adenocarcinoma (RA), tumor‑adjacent and tumor‑distant tissues. Preoperative determining optimal distal resection margin (DRM) is crucial for formulating surgical options. The present study aimed to assess ADC differences between RA and 1 cm‑layer distal paracancerous tissues, providing a potential reference basis for preoperatively determining optimal DRM. A total of 110 consecutive patients with mid‑high RA undergoing preoperative diffusion‑weighted imaging were included. ADCs of RA and distal paracancerous tissues located ~1, 2 and 3 cm from the tumor margin (defined as D1, D2 and D3, respectively) were measured using five b‑value pairs (0 and 50; 0 and 100; 0 and 800; 0 and 1,000; and 0 and 1,500 sec/mm2). Differences in ADCs between RA, D1, D2 and D3 were compared using the Friedman test with a post hoc Bonferroni correction. Variables that demonstrated statistical differences in multiple pairwise comparisons underwent receiver operating characteristic (ROC) analysis to assess diagnostic performance of ADCs in distinguishing between tissues. ADC at all b‑value pairs demonstrated satisfactory performance in distinguishing RA from D1, D2 and D3 [areas under the ROC curves (AUCs), 0.838 to 0.996)]. When the maximum b‑value was ≥800 sec/mm2, the ADC of D1 was significantly lower compared with those of D2 and D3 (P<0.001). ADC exhibited an optimal performance in differentiating D1 from D2 at b‑values of 0 and 800 sec/mm2, and D1 from D3 at b‑values of 0 and 1,000 sec/mm2 (AUCs: 0.652 and 0.692, respectively). However, ADCs of D2 and D3 demonstrated no differences at all b‑value pairs (all P>0.05). In conclusion, ADC may distinguish RA from D1, D2 and D3, and D1 from D2/D3, but cannot distinguish between D2 and D3.
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Spandidos Publications style
Luo H, Gou Y, Wang Y, Qin H, Zhou H, Zhang X and Chen T: Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncol Lett 29: 97, 2025.
APA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., & Chen, T. (2025). Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue. Oncology Letters, 29, 97. https://doi.org/10.3892/ol.2024.14843
MLA
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29.2 (2025): 97.
Chicago
Luo, H., Gou, Y., Wang, Y., Qin, H., Zhou, H., Zhang, X., Chen, T."Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue". Oncology Letters 29, no. 2 (2025): 97. https://doi.org/10.3892/ol.2024.14843