Open Access

Role, mechanisms and effects of Radix Bupleuri in anti‑breast cancer (Review)

  • Authors:
    • Shiting Jiang
    • Chengxia Li
    • Dan Liu
    • Fancai Zeng
    • Wenli Wei
    • Tao He
    • Wenli Yang
  • View Affiliations

  • Published online on: January 30, 2025     https://doi.org/10.3892/ol.2025.14912
  • Article Number: 166
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The prevalence of breast cancer among women has led to a growing need for innovative anti‑breast cancer medications and an in‑depth investigation into their molecular mechanisms of action, both of which are essential tactics in clinical intervention. In the clinical practice of Traditional Chinese Medicine, Radix Bupleuri and its active components have shown promise as potential anti‑breast cancer agents due to their ability to target multiple pathways, exhibit synergistic effects and reduce toxicity. These compounds are considered to enhance the prognosis of patients with cancer, prolong survival and combat chemotherapy resistance. The present review aimed to delve into the anti‑breast cancer properties of Radix Bupleuri and its active ingredients, highlighting their mechanisms, such as inhibition of cell proliferation, promotion of apoptosis, metastasis prevention, microenvironment improvement and synergy with certain chemotherapeutic agents. These findings may provide a scientific rationale for combining Radix Bupleuri and its active components with traditional chemotherapy agents for the management of breast cancer.
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April-2025
Volume 29 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Jiang S, Li C, Liu D, Zeng F, Wei W, He T and Yang W: Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncol Lett 29: 166, 2025.
APA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., & Yang, W. (2025). Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review). Oncology Letters, 29, 166. https://doi.org/10.3892/ol.2025.14912
MLA
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29.4 (2025): 166.
Chicago
Jiang, S., Li, C., Liu, D., Zeng, F., Wei, W., He, T., Yang, W."Role, mechanisms and effects of <em>Radix Bupleuri</em> in anti‑breast cancer (Review)". Oncology Letters 29, no. 4 (2025): 166. https://doi.org/10.3892/ol.2025.14912