|
1
|
Ali J, Sabiha B, Jan HU, Haider SA, Khan
AA and Ali SS: Genetic etiology of oral cancer. Oral Oncol.
70:23–28. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA CancerJ Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jansen L, Buttmann-Schweiger N, Listl S,
Ressing M, Holleczek B, Katalinic A, Luttmann S, Kraywinkel K and
Brenner H; GEKID Cancer Survival Working Group, : Differences in
incidence and survival of oral cavity and pharyngeal cancers
between Germany and the United States depend on the HPV-association
of the cancer site. Oral Oncol. 76:8–15. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Johnson DE, Burtness B, Leemans CR, Lui
VWY, Bauman JE and Grandis JR: Head and neck squamous cell
carcinoma. Nat Rev Dis Primers. 6:922020. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Aires FT, Lin CS, Matos LL, Kulcsar MAV
and Cernea CR: Risk factors for distant metastasis in patients with
oral cavity squamous cell carcinoma undergoing surgical treatment.
ORL J Otorhinolaryngol Relat Spec. 79:347–355. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Chi AC, Day TA and Neville BW: Oral cavity
and oropharyngeal squamous cell carcinoma-an update. CA Cancer J
Clin. 65:401–421. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zhang Y and Weinberg RA:
Epithelial-to-mesenchymal transition in cancer: Complexity and
opportunities. Front Med. 12:361–373. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Gloushankova NA, Zhitnyak IY and Rubtsova
SN: Role of epithelial-mesenchymal transition in tumor progression.
Biochemistry (Mosc). 83:1469–1476. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pastushenko I, Brisebarre A, Sifrim A,
Fioramonti M, Revenco T, Boumahdi S, Van Keymeulen A, Brown D,
Moers V, Lemaire S, et al: Identification of the tumour transition
states occurring during EMT. Nature. 556:463–468. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Nieto MA, Huang RY, Jackson RA and Thiery
JP: EMT: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Feng XL, Ho SC, Mo XF, Lin FY, Zhang NQ,
Luo H, Zhang X and Zhang CX: Association between flavonoids,
flavonoid subclasses intake and breast cancer risk: A case-control
study in China. Eur J Cancer Prev. 29:493–500. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Surichan S, Arroo RR, Ruparelia K,
Tsatsakis AM and Androutsopoulos VP: Nobiletin bioactivation in
MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.
Food Chem Toxicol. 113:228–235. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Chen M, Li H, Zheng S, Shen J, Chen Y, Li
Y, Yuan M, Wu J and Sun Q: Nobiletin targets SREBP1/ACLY to induce
autophagy-dependent cell death of gastric cancer cells through
PI3K/Akt/mTOR signaling pathway. Phytomedicine. 128:1553602024.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Uesato S, Yamashita H, Maeda R, Hirata Y,
Yamamoto M, Matsue S, Nagaoka Y, Shibano M, Taniguchi M, Baba K and
Ju-ichi M: Synergistic antitumor effect of a combination of
paclitaxel and carboplatin with nobiletin from Citrus depressa on
non-small-cell lung cancer cell lines. Planta Med. 80:452–457.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ma X, Jin S, Zhang Y, Wan L, Zhao Y and
Zhou L: Inhibitory effects of nobiletin on hepatocellular carcinoma
in vitro and in vivo. Phytother Res. 28:560–567. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Cheng HL, Hsieh MJ, Yang JS, Lin CW, Lue
KH, Lu KH and Yang SF: Nobiletin inhibits human osteosarcoma cells
metastasis by blocking ERK and JNK-mediated MMPs expression.
Oncotarget. 7:35208–35223. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Rosas-Martínez M, González Rosales JA and
Gutiérrez-Venegas G: Nobiletin regulates invasion, migration and
metastasis in hypopharyngeal squamous cell carcinoma. Cell Mol Biol
(Noisy-le-grand). 69:1–6. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Chiou YS, Zheng YN, Tsai ML, Lai CS, Ho CT
and Pan MH: 5-Demethylnobiletin more potently inhibits colon cancer
cell growth than nobiletin in vitro and in vivo. J Food Bioact.
2:91–97. 2018. View Article : Google Scholar
|
|
19
|
Zheng J, Bi J, Johnson D, Sun Y, Song M,
Qiu P, Dong P, Decker E and Xiao H: Analysis of 10 metabolites of
polymethoxyflavones with high sensitivity by electrochemical
detection in high-performance liquid chromatography. J Agric Food
Chem. 63:509–516. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yang F, Li T, Zhang XQ, Gong Y, Su H, Fan
J, Wang L, Hu QD and Tan RZ: Screening of active components in
Astragalus mongholicus Bunge and Panax notoginseng formula for
anti-fibrosis in CKD: Nobiletin inhibits Lgals1/PI3K/AKT signaling
to improve renal fibrosis. Ren Fail. 46:23750332024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wu X, Song M, Qiu P, Li F, Wang M, Zheng
J, Wang Q, Xu F and Xiao H: A metabolite of nobiletin,
4′-demethylnobiletin and atorvastatin synergistically inhibits
human colon cancer cell growth by inducing G0/G1 cell cycle arrest
and apoptosis. Food Funct. 9:87–95. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Qiu P, Dong P, Guan H, Li S, Ho CT, Pan
MH, McClements DJ and Xiao H: Inhibitory effects of 5-hydroxy
polymethoxyflavones on colon cancer cells. Mol Nutr Food Res. 54
(Suppl 2):S244–S252. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Goh JXH, Tan LT, Goh JK, Chan KG,
Pusparajah P, Lee LH and Goh BH: Nobiletin and derivatives:
Functional compounds from citrus fruit peel for colon cancer
chemoprevention. Cancers (Basel). 11:8672019. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Moon JY, Manh Hung LV, Unno T and Cho SK:
Nobiletin enhances chemosensitivity to adriamycin through
modulation of the Akt/GSK3β/β-catenin/MYCN/MRP1 signaling pathway
in A549 human non-small-cell lung cancer cells. Nutrients.
10:18292018. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Jiang H, Chen H, Jin C, Mo J and Wang H:
Nobiletin flavone inhibits the growth and metastasis of human
pancreatic cancer cells via induction of autophagy, G0/G1 cell
cycle arrest and inhibition of NF-kB signalling pathway. J BUON.
25:1070–1075. 2020.PubMed/NCBI
|
|
26
|
Yang J, Yang Y, Wang L, Jin Q and Pan M:
Nobiletin selectively inhibits oral cancer cell growth by promoting
apoptosis and DNA damage in vitro. Oral Surg Oral Med Oral Pathol
Oral Radiol. 130:419–427. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chen Q, Gu Y, Tan C, Sundararajan B, Li Z,
Wang D and Zhou Z: Comparative effects of five polymethoxyflavones
purified from Citrus tangerina on inflammation and cancer.
Front Nutr. 9:9636622022. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Miyata Y, Sato T, Imada K, Dobashi A, Yano
M and Ito A: A citrus polymethoxyflavonoid, nobiletin, is a novel
MEK inhibitor that exhibits antitumor metastasis in human
fibrosarcoma HT-1080 cells. Biochem Biophys Res Commun.
366:168–173. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Da C, Liu Y, Zhan Y, Liu K and Wang R:
Nobiletin inhibits epithelial-mesenchymal transition of human
non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3
signaling pathway. Oncol Rep. 35:2767–2774. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Gao XJ, Liu JW, Zhang QG, Zhang JJ, Xu HT
and Liu HJ: Nobiletin inhibited hypoxia-induced
epithelial-mesenchymal transition of lung cancer cells by
inactivating of Notch-1 signa ling and switching on miR-200b.
Pharmazie. 70:256–262. 2015.PubMed/NCBI
|
|
31
|
Keshtkar S, Kaviani M, Jabbarpour Z,
Geramizadeh B, Motevaseli E, Nikeghbalian S, Shamsaeefar A,
Motazedian N, Al-Abdullah IH, Ghahremani MH and Azarpira N:
Protective effect of nobiletin on isolated human islets survival
and function against hypoxia and oxidative stress-induced
apoptosis. Sci Rep. 9:117012019. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang
X and Pan J: Nobiletin inhibits IL-1β-induced inflammation in
chondrocytes via suppression of NF-κB signaling and attenuates
osteoarthritis in mice. Front Pharmacol. 10:5702019. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Youn K, Lee S and Jun M: Discovery of
nobiletin from citrus peel as a potent inhibitor of β-amyloid
peptide toxicity. Nutrients. 11:26482019. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Tsuboi T, Lu R, Yonezawa T, Watanabe A,
Woo JT, Abe-Dohmae S and Yokoyama S: Molecular mechanism for
nobiletin to enhance ABCA1/G1 expression in mouse macrophages.
Atherosclerosis. 297:32–39. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhang BF, Jiang H, Ch J, Guo X, Li Y, Hu Q
and Yang S: Nobiletin ameliorates myocardial ischemia and
reperfusion injury by attenuating endoplasmic reticulum
stress-associated apoptosis through regulation of the PI3K/AKT
signal pathway. Int Immunopharmacol. 73:98–107. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yuk T, Kim Y, Yang J, Sung J, Jeong HS and
Lee J: Nobiletin inhibits hepatic lipogenesis via activation of
AMP-activated protein kinase. Evid Based Complement Altern Med.
2018:74202652018. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Li S, Pan MH, Lai CS, Lo CY, Dushenkov S
and Ho CT: Isolation and syntheses of polymethoxyflavones and
hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Bioorg Med Chem. 15:3381–3389. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Xiao H, Yang CS, Li S, Jin H, Ho CT and
Patel T: Monodemethylated polymethoxyflavones from sweet orange
(Citrus sinensis) peel inhibit growth of human lung cancer cells by
apoptosis. Mol Nutr Food Res. 53:398–406. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Asakawa T, Sagara H, Kanakogi M, Hiza A,
Tsukaguchi Y, Ogawa T, Nakayama M, Ouchi H, Inai M and Kan T:
Practical synthesis of polymethylated flavones: Nobiletin and its
desmethyl derivatives. Org Process Res Dev. 23:595–602. 2019.
View Article : Google Scholar
|
|
40
|
Song M, Lan Y, Wu X, Han Y, Wang M, Zheng
J, Li Z, Li F, Zhou J, Xiao J, et al: The chemopreventive effect of
5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven
colorectal carcinogenesis in mice is associated with its colonic
metabolites. Food Funct. 11:4940–4952. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Song M, Wu X, Charoensinphon N, Wang M,
Zheng J, Gao Z, Xu F, Li Z, Li F, Zhou J and Xiao H: Dietary
5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung
tumorigenesis in mice. Food Funct. 8:954–963. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Nemoto K, Ikeda A, Yoshida C, Kimura J,
Mori J, Fujiwara H, Yokosuka A, Mimaki Y, Ohizumi Y and Degawa M:
Characteristics of nobiletin-mediated alteration of gene expression
in cultured cell lines. Biochem Biophys Res Commun. 431:530–534.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhang X, Zheng K, Li C, Zhao Y, Li H, Liu
X, Long Y and Yao J: Nobiletin inhibits invasion via inhibiting
AKT/GSK3β/β-catenin signaling pathway in Slug-expressing glioma
cells. Oncol Rep. 37:2847–2856. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Andugulapati SB, Gourishetti K,
Tirunavalli SK, Shaikh TB and Sistla R: Biochanin-A ameliorates
pulmonary fibrosis by suppressing the TGF-β mediated EMT,
myofibroblasts differentiation and collagen deposition in in vitro
and in vivo systems. Phytomedicine. 78:1532982020. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ma X, Xie Y, Gong Y, Hu C, Qiu K, Yang Y,
Shen H, Zhou X, Long C and Lin X: Silibinin prevents TGFβ-induced
EMT of RPE in proliferative vitreoretinopathy by inhibiting Stat3
and Smad3 phosphorylation. Invest Ophthalmol Vis Sci. 64:472023.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Peng L, Wen L, Shi QF, Gao F, Huang B,
Meng J, Hu CP and Wang CM: Scutellarin ameliorates pulmonary
fibrosis through inhibiting NF-κB/NLRP3-mediated
epithelial-mesenchymal transition and inflammation. Cell Death Dis.
11:9782020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Liu F, Zhang S, Yin M, Guo L, Xu M and
Wang Y: Nobiletin inhibits hypoxia-induced epithelial-mesenchymal
transition in renal cell carcinoma cells. J Cell Biochem.
120:2039–2046. 2019. View Article : Google Scholar : PubMed/NCBI
|
