Diffuse myocardial infiltration in secondary cardiac lymphoma: A case report

Huang,Dan; Wu,Chunyan; Xiao,Liming; Lin,Binwei; He,Chuandong; Du,Xiaobo

doi:10.3892/ol.2025.15009

Diffuse myocardial infiltration in secondary cardiac lymphoma: A case report

Authors:
- Dan Huang
- Chunyan Wu
- Liming Xiao
- Binwei Lin
- Chuandong He
- Xiaobo Du
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Affiliations: Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang, Sichuan 621000, P.R. China, Department of Oncology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang, Sichuan 621000, P.R. China
Published online on: April 2, 2025 https://doi.org/10.3892/ol.2025.15009
Article Number: 263

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Abstract

Cardiac lymphomas are rare, with a high proportion developing as secondary lymphomas. The symptoms of secondary heart lymphoma are often nonspecific and may not be detected promptly, leading to a poor prognosis. This case report describes the case of a 53‑year‑old male patient diagnosed with diffuse large B‑cell lymphoma originating in the thymus. Prior to treatment, ¹⁸F‑fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of diffuse lymphoma invasion in the heart. After chemotherapy, the cardiac lesions largely regressed. Cardiac magnetic resonance imaging, echocardiography and PET/CT revealed post‑chemotherapy tumor necrosis and fibrosis in the myocardium, resulting in the formation of a left ventricular aneurysm. This case report discusses the diagnosis and treatment of secondary cardiac lymphoma, focusing on diffuse myocardial infiltration as the primary manifestation.

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1	Basso C, Valente M, Poletti A, Casarotto D and Thiene G: Surgical pathology of primary cardiac and pericardial tumors. Eur J Cardiothorac Surg. 12:730–738. 1997. View Article : Google Scholar : PubMed/NCBI
2	Jeudy J, Burke AP and Frazier AA: Cardiac lymphoma. Radiol Clin North Am. 54:689–710. 2016. View Article : Google Scholar : PubMed/NCBI
3	Bonelli A, Paris S, Bisegna S, Milesi G, Gavazzi E, Giubbini R, Cattaneo C, Facchetti F and Faggiano P: Cardiac lymphoma with early response to chemotherapy: A case report and review of the literature. J Nucl Cardiol. 29:3044–3056. 2022. View Article : Google Scholar : PubMed/NCBI
4	Voigt P, Wienbeck S, Weber MA, Oyama-Manabe N, Beimler M, Schob S, Kahn T, Meyer HJ, Randaxhe JF and Surov A: Cardiac hematological malignancies: Typical growth patterns, imaging features, and clinical outcome. Angiology. 69:170–176. 2018. View Article : Google Scholar : PubMed/NCBI
5	Nakagawa Y, Ikeda U, Hirose M, Ubukata S, Katsuki TA, Kaminishi Y, Saito T, Hironaka M, Izumi T and Shimada K: Successful treatment of primary cardiac lymphoma with monoclonal CD20 antibody (rituximab). Circ J. 68:172–173. 2004. View Article : Google Scholar : PubMed/NCBI
6	Zhao Y, Huang S, Ma C, Zhu H and Bo J: Clinical features of cardiac lymphoma: An analysis of 37 cases. J Int Med Res. 49:3000605219995582021. View Article : Google Scholar : PubMed/NCBI
7	Kondo S, Osanai H, Sakamoto Y, Uno H, Tagahara K, Hosono H, Miyamoto S, Hiramatsu S, Matsumoto H, Sakaguchi T, et al: Secondary cardiac lymphoma presenting as sick sinus syndrome and atrial fibrillation which required leadless pacemaker implantation. Intern Med. 60:431–434. 2021. View Article : Google Scholar : PubMed/NCBI
8	Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, et al: Cardiac tumors: Diagnosis, prognosis, and treatment. Curr Cardiol Rep. 22:1692020. View Article : Google Scholar : PubMed/NCBI
9	Ido T, Minamiguchi H, Ichibori Y, Hayashi T, Makino N, Hirayama A and Higuchi Y: Cardiac involvement of diffuse large B-cell lymphoma presenting as various arrythmias. Clin Case Rep. 10:e65042022. View Article : Google Scholar : PubMed/NCBI
10	Shi X, Yang Y, Zhang W, Wang J, Xiao D, Ren H, Wang T, Gao F, Liu Z, Zhou K, et al: FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy. Proc Natl Acad Sci USA. 119:e22085061192022. View Article : Google Scholar : PubMed/NCBI
11	National Comprehensive Cancer Network (NCCN), . Clinical Practice Guidelines in Oncology (NCCN Guidelines^®): B-Cell Lymphomas, Version 2. NCCN; Plymouth Meeting, PA: 2025
12	Fujisaki J, Tanaka T, Kato J, Saito T, Yano K, Shimizu Y, Sada T, Kitazume K, Fujita A and Kira Y: Primary cardiac lymphoma presenting clinically as restrictive cardiomyopathy. Circ J. 69:249–252. 2005. View Article : Google Scholar : PubMed/NCBI
13	Kuchynka P, Palecek T, Lambert L, Masek M and Knotkova V: Cardiac involvement in lymphoma mimicking hypertrophic cardiomyopathy. Kardiol Pol. 76:12782018. View Article : Google Scholar : PubMed/NCBI
14	Lau L, Mozolevska V, Kirkpatrick IDC, Jassal DS and Kansara R: Diffuse large B-cell lymphoma mimicking cardiac amyloidosis. Clin Case Rep. 5:1034–1035. 2017. View Article : Google Scholar : PubMed/NCBI
15	Poterucha TJ, Kochav J, O'Connor DS and Rosner GF: Cardiac tumors: Clinical presentation, diagnosis, and management. Curr Treat Options Oncol. 20:662019. View Article : Google Scholar : PubMed/NCBI
16	Al-Mehisen R, Al-Mohaissen M and Yousef H: Cardiac involvement in disseminated diffuse large B-cell lymphoma, successful management with chemotherapy dose reduction guided by cardiac imaging: A case report and review of literature. World J Clin Cases. 7:191–202. 2019. View Article : Google Scholar : PubMed/NCBI
17	Maleszewski JJ, Anavekar NS and Moynihan TJ: KW: Pathology, imaging, and treatment of cardiac tumours. Nat Rev Cardiol. 14:536–549. 2017. View Article : Google Scholar : PubMed/NCBI
18	Vinicki JP, Cianciulli TF, Farace GA, Saccheri MC, Lax JA, Kazelian LR and Wachs A: Complete regression of myocardial involvement associated with lymphoma following chemotherapy. World J Cardiol. 5:364–368. 2013. View Article : Google Scholar : PubMed/NCBI
19	Soens L, Schoors D and Van Camp G: Acute heart failure due to fulminant myocardial infiltration by a diffuse large B-cell lymphoma. Acta Cardiol. 67:101–104. 2012. View Article : Google Scholar : PubMed/NCBI
20	Li YH, Shi CY, Duan FQ, Pang Y, Li HB, Zhang LQ, Liu ZH, Ouyang L, Yue CY, Xie MC, et al: A clinical analysis of 10 cases with cardiac lymphoma. Zhonghua Xue Ye Xue Za Zhi. 38:102–106. 2017.(In Chinese). PubMed/NCBI
21	Yang Y, Li Z, Li Y, Zhao Y and Shi M: Relapsed/refractory diffuse large B cell lymphoma with cardiac involvement: A case report and literature review. Front Oncol. 13:10910742023. View Article : Google Scholar : PubMed/NCBI