Open Access

The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review)

  • Authors:
    • Jin-Long Shi
    • Chen-Shi Lin
    • Ming-Hui Gong
    • Zhi-Qiang Cai
  • View Affiliations

  • Published online on: April 7, 2025     https://doi.org/10.3892/ol.2025.15016
  • Article Number: 270
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) are key regulators of gene expression at transcriptional and post‑transcriptional levels and serve roles in tumour progression, cancer diagnosis and prognosis. Among these, family with sequence similarity 83 member H‑antisense RNA 1 (FAM83H‑AS1) is an oncogenic lncRNA with elevated expression in several malignancies. FAM83H‑AS1 promotes cancer cell proliferation, inhibits apoptosis, enhances migration and contributes to chemoresistance through interactions with microRNA (miR)‑136‑5p, miR‑545‑3p, miR‑15a miR‑10a‑5p and signalling pathways such as Wnt/β‑catenin and Notch receptor. FAM83H‑AS1 may be a promising biomarker for cancer diagnosis and prognosis. The present review summarises the expression, mechanism and potential clinical application of FAM83H‑AS1 in cancer diagnosis and prognosis.
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June-2025
Volume 29 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Shi J, Lin C, Gong M and Cai Z: The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review). Oncol Lett 29: 270, 2025.
APA
Shi, J., Lin, C., Gong, M., & Cai, Z. (2025). The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review). Oncology Letters, 29, 270. https://doi.org/10.3892/ol.2025.15016
MLA
Shi, J., Lin, C., Gong, M., Cai, Z."The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review)". Oncology Letters 29.6 (2025): 270.
Chicago
Shi, J., Lin, C., Gong, M., Cai, Z."The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review)". Oncology Letters 29, no. 6 (2025): 270. https://doi.org/10.3892/ol.2025.15016