Aggressive local therapy for de novo metastatic breast cancer: Challenges and updates (Review)
- Authors:
- Bailong Liu
- Hui Liu
- Min Liu
-
Affiliations: Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China - Published online on: July 14, 2023 https://doi.org/10.3892/or.2023.8600
- Article Number: 163
-
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Thomas A, Khan SA, Chrischilles EA and Schroeder MC: Initial surgery and survival in stage IV breast cancer in the United States, 1988–2011. JAMA Surg. 151:424–431. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong Z, Deng G, Wang J, Li X, Xie X, Shuang Z and Wang X: Could local surgery improve survival in de novo stage IV breast cancer? BMC Cancer. 18:8852018. View Article : Google Scholar : PubMed/NCBI | |
|
Eng LG, Dawood S, Sopik V, Haaland B, Tan PS, Bhoo-Pathy N, Warner E, Iqbal J, Narod SA and Dent R: Ten-year survival in women with primary stage IV breast cancer. Breast Cancer Res Treat. 160:145–152. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Malmgren JA, Mayer M, Atwood MK and Kaplan HG: Differential presentation and survival of de novo and recurrent metastatic breast cancer over time: 1990–2010. Breast Cancer Res Treat. 167:579–590. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tao L, Chu L, Wang LI, Moy L, Brammer M, Song C, Green M, Kurian AW, Gomez SL and Clarke CA: Occurrence and outcome of de novo metastatic breast cancer by subtype in a large, diverse population. Cancer Causes Control. 27:1127–1138. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yoo TK, Chae BJ, Kim SJ, Lee J, Yoon TI, Lee SJ, Park HY, Park HK, Eom YH, Kim HS, et al: Identifying long-term survivors among metastatic breast cancer patients undergoing primary tumor surgery. Breast Cancer Res Treat. 165:109–118. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lane WO, Thomas SM, Blitzblau RC, Plichta JK, Rosenberger LH, Fayanju OM, Hyslop T, Hwang ES and Greenup RA: Surgical resection of the primary tumor in women with de novo stage IV breast cancer: Contemporary practice patterns and survival analysis. Ann Surg. 269:537–544. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bafford AC, Burstein HJ, Barkley CR, Smith BL, Lipsitz S, Iglehart JD, Winer EP and Golshan M: Breast surgery in stage IV breast cancer: Impact of staging and patient selection on overall survival. Breast Cancer Res Treat. 115:7–12. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Rapiti E, Verkooijen HM, Vlastos G, Fioretta G, Neyroud-Caspar I, Sappino AP, Chappuis PO and Bouchardy C: Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol. 24:2743–2749. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Babiera GV, Rao R, Feng L, Meric-Bernstam F, Kuerer HM, Singletary SE, Hunt KK, Ross MI, Gwyn KM, Feig BW, et al: Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol. 13:776–782. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C and Margenthaler JA: Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: Analysis of the 1988–2003 SEER data. Ann Surg Oncol. 14:2187–2194. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Fields RC, Jeffe DB, Trinkaus K, Zhang Q, Arthur C, Aft R, Dietz JR, Eberlein TJ, Gillanders WE and Margenthaler JA: Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol. 14:3345–3351. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Bhoo-Pathy N, Verkooijen HM, Tan EY, Miao H, Taib NA, Brand JS, Dent RA, See MH, Subramaniam S, Chan P, et al: Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting. Sci Rep. 5:162522015. View Article : Google Scholar : PubMed/NCBI | |
|
Pons-Tostivint E, Alouani E, Kirova Y, Dalenc F and Vaysse C: Is there a role for locoregional treatment of the primary tumor in de novo metastatic breast cancer in the era of tailored therapies?: Evidences, unresolved questions and a practical algorithm. Crit Rev Oncol Hematol. 157:1031462021. View Article : Google Scholar : PubMed/NCBI | |
|
Pons-Tostivint E, Kirova Y, Lusque A, Campone M, Geffrelot J, Mazouni C, Mailliez A, Pasquier D, Madranges N, Firmin N, et al: Survival impact of locoregional treatment of the primary tumor in de novo metastatic breast cancers in a large multicentric cohort study: A propensity score-matched analysis. Ann Surg Oncol. 26:356–365. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Soran A, Ozmen V, Ozbas S, Karanlik H, Muslumanoglu M, Igci A, Canturk Z, Utkan Z, Ozaslan C, Evrensel T, et al: Randomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: Protocol MF07-01. Ann Surg Oncol. 25:3141–3149. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Fitzal F, Bjelic-Radisic V, Knauer M, Steger G, Hubalek M, Balic M, Singer C, Bartsch R, Schrenk P, Soelkner L, et al: Impact of breast surgery in primary metastasized breast cancer: Outcomes of the prospective randomized phase III ABCSG-28 POSYTIVE trial. Ann Surg. 269:1163–1169. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Badwe R, Hawaldar R, Nair N, Kaushik R, Parmar V, Siddique S, Budrukkar A, Mittra I and Gupta S: Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: An open-label randomised controlled trial. Lancet Oncol. 16:1380–1388. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Harris E, Barry M and Kell MR: Meta-analysis to determine if surgical resection of the primary tumour in the setting of stage IV breast cancer impacts on survival. Ann Surg Oncol. 20:2828–2834. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Petrelli F and Barni S: Surgery of primary tumors in stage IV breast cancer: An updated meta-analysis of published studies with meta-regression. Med Oncol. 29:3282–3290. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao W, Zou Y, Zheng S, Hu X, Liu P and Xie X, Yu P, Tang H and Xie X: Primary tumor resection in stage IV breast cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 44:1504–1512. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Headon H, Wazir U, Kasem A and Mokbel K: Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta-analysis. Mol Clin Oncol. 4:863–867. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Gera R, Chehade HELH, Wazir U, Tayeh S, Kasem A and Mokbel K: Locoregional therapy of the primary tumour in de novo stage IV breast cancer in 216 066 patients: A meta-analysis. Sci Rep. 10:29522020. View Article : Google Scholar : PubMed/NCBI | |
|
Arciero C, Liu Y, Gillespie T and Subhedar P: Surgery and survival in patients with stage IV breast cancer. Breast J. 25:644–653. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Cortesi L, Toss A, Cirilli C, Marcheselli L, Braghiroli B, Sebastiani F and Federico M: Twenty-years experience with de novo metastatic breast cancer. Int J Cancer. 137:1417–1426. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao W, Wu L, Zhao A, Zhang M, Tian Q, Shen Y, Wang F, Wang B, Wang L, Chen L, et al: A nomogram for predicting survival in patients with de novo metastatic breast cancer: A population-based study. BMC Cancer. 20:9822020. View Article : Google Scholar : PubMed/NCBI | |
|
Di Meglio A, Freedman RA, Lin NU, Barry WT, Metzger-Filho O, Keating NL, King TA, Sertoli MR, Boccardo F, Winer EP and Vaz-Luis I: Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: A population-based analysis. Breast Cancer Res Treat. 157:587–596. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Bitencourt A, Rossi Saccarelli C, Morris EA, Flynn J, Zhang Z, Khan A, Gillespie E, Cahlon O, Mueller B, Cuaron JJ, et al: Regional lymph node involvement among patients with de novo metastatic breast cancer. JAMA Netw Open. 3:e20187902020. View Article : Google Scholar : PubMed/NCBI | |
|
Shen T, Siegal GP and Wei S: Clinicopathologic factors associated with de novo metastatic breast cancer. Pathol Res Pract. 212:1167–1173. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Shen T, Gao C, Zhang K, Siegal GP and Wei S: Prognostic outcomes in advanced breast cancer: The metastasis-free interval is important. Hum Pathol. 70:70–76. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lobbezoo DJA, van Kampen RJW, Voogd AC, Dercksen MW, van den Berkmortel F, Smilde TJ, van de Wouw AJ, Peters FP, van Riel JMGH, Peters NAJB, et al: Prognosis of metastatic breast cancer: Are there differences between patients with de novo and recurrent metastatic breast cancer? Br J Cancer. 112:1445–1251. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Dawood S, Broglio K, Ensor J, Hortobagyi GN and Giordano SH: Survival differences among women with de novo stage IV and relapsed breast cancer. Ann Oncol. 21:2169–2174. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yardley DA, Kaufman PA, Brufsky A, Yood MU, Rugo H, Mayer M, Quah C, Yoo B and Tripathy D: Treatment patterns and clinical outcomes for patients with de novo versus recurrent HER2-positive metastatic breast cancer. Breast Cancer Res Treat. 145:725–734. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lao C, Kuper-Hommel M, Elwood M, Campbell I, Edwards M and Lawrenson R: Characteristics and survival of de novo and recurrent metastatic breast cancer in New Zealand. Breast Cancer. 28:387–397. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
den Brok WD, Speers CH, Gondara L, Baxter E, Tyldesley SK and Lohrisch CA: Survival with metastatic breast cancer based on initial presentation, de novo versus relapsed. Breast Cancer Res Treat. 161:549–556. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Nieder C, Mannsåker B and Haukland E: Exceptional responses to standard therapy in a patient with metastatic HER2-positive breast cancer. Cureus. 9:e14122017.PubMed/NCBI | |
|
Gobbini E, Ezzalfani M, Dieras V, Bachelot T, Brain E, Debled M, Jacot W, Mouret-Reynier MA, Goncalves A, Dalenc F, et al: Time trends of overall survival among metastatic breast cancer patients in the real-life ESME cohort. Eur J Cancer. 96:17–24. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Elbaiomy MA, Akl T, Atwan N, Elsayed AA, Elzaafarany M and Shamaa S: Clinical impact of breast cancer stem cells in metastatic breast cancer patients. J Oncol. 2020:25617262020. View Article : Google Scholar : PubMed/NCBI | |
|
Dawood S, Haaland B, Albaracin C, Gupta S, Cortes J, Sim YY and Dent RA: Is the proportion of patients diagnosed with synchronous stage IV breast cancer who survive more than two years increasing over time? Oncology. 89:79–87. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ogiya R, Sagara Y, Niikura N and Freedman RA: Impact of subtype on survival of young patients with stage IV breast cancer. Clin Breast Cancer. 19:200–207.e1. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Vaz-Luis I, Lin NU, Keating NL, Barry WT, Winer EP and Freedman RA: Factors associated with early mortality among patients with de novo metastatic breast cancer: A population-based study. Oncologist. 22:386–393. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen H, Zhang M, Wang M, Zhang P, Bai F and Wu K: Immediate breast reconstruction in de novo metastatic breast cancer: An analysis of 563 cases based on the SEER database. Clin Breast Cancer. 19:e135–e141. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Khan SA, Stewart AK and Morrow M: Does aggressive local therapy improve survival in metastatic breast cancer? Surgery. 132:620–627. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Soares LR, Freitas-Junior R, Curado MP, Paulinelli RR, Martins E and Oliveira JC: Low overall survival in women with de novo metastatic breast cancer: Does this reflect tumor biology or a lack of access to health care? JCO Glob Oncol. 6:679–687. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Blanchard DK, Shetty PB, Hilsenbeck SG and Elledge RM: Association of surgery with improved survival in stage IV breast cancer patients. Ann Surg. 247:732–738. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
King TA, Lyman JP, Gonen M, Voci A, De Brot M, Boafo C, Sing AP, Hwang ES, Alvarado MD, Liu MC, et al: Prognostic impact of 21-gene recurrence score in patients with stage IV breast cancer: TBCRC 013. J Clin Oncol. 34:2359–2365. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Carmichael AR, Anderson EDC, Chetty U and Dixon JM: Does local surgery have a role in the management of stage IV breast cancer? Eur J Surg Oncol. 29:17–19. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Lin C, Wu J, Ding S, Goh C, Andriani L, Lu S, Shen K and Zhu L: Subdivision of M1 stage for de novo metastatic breast cancer to better predict prognosis and response to primary tumor surgery. J Natl Compr Canc Netw. 17:1521–1528. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Plichta JK, Thomas SM, Sergesketter AR, Greenup RA, Rosenberger LH, Fayanju OM, Kimmick G, Force J, Hyslop T and Hwang ES: A novel staging system for de novo metastatic breast cancer refines prognostic estimates. Ann Surg. 275:784–792. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Garrido-Castro AC, Spurr LF, Hughes ME, Li YY, Cherniack AD, Kumari P, Lloyd MR, Bychkovsky B, Barroso-Sousa R, Di Lascio S, et al: Genomic characterization of de novo metastatic breast cancer. Clin Cancer Res. 27:1105–1118. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Seltzer S, Corrigan M and O'Reilly S: The clinicomolecular landscape of de novo versus relapsed stage IV metastatic breast cancer. Exp Mol Pathol. 114:1044042020. View Article : Google Scholar : PubMed/NCBI | |
|
McKenzie HS, Maishman T, Simmonds P, Durcan L; POSH Steering Group, ; Eccles D and Copson E: Survival and disease characteristics of de novo versus recurrent metastatic breast cancer in a cohort of young patients. Br J Cancer. 122:1618–1629. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Di Meglio A, Lin NU, Freedman RA, Barry WT, Winer EP and Vaz-Luis I: Patterns of utilization of imaging studies and serum tumor markers among patients with de novo metastatic breast cancer. J Natl Compr Canc Netw. 15:316–324. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Shien T, Kinoshita T, Shimizu C, Hojo T, Taira N, Doihara H and Akashi-Tanaka S: Primary tumor resection improves the survival of younger patients with metastatic breast cancer. Oncol Rep. 21:827–832. 2009.PubMed/NCBI | |
|
Barinoff J, Schmidt M, Schneeweiss A, Schoenegg W, Thill M, Keitel S, Lattrich CR, Hinke A, Kutscheidt A and Jackisch C: Primary metastatic breast cancer in the era of targeted therapy-prognostic impact and the role of breast tumour surgery. Eur J Cancer. 83:116–124. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Co M, Ng J and Kwong A: De-novo metastatic breast cancers with or without primary tumor resection-A 10-year study. Cancer Treat Res Commun. 19:1001182019. View Article : Google Scholar : PubMed/NCBI | |
|
Kwong A and Co M: Long term survival study of de-novo metastatic breast cancers with or without primary tumour resection. Cancer Treat Res Commun. 20:1001482019. View Article : Google Scholar : PubMed/NCBI | |
|
Rao R, Feng L, Kuerer HM, Singletary SE, Bedrosian I, Hunt KK, Ross MI, Hortobagyi GN, Feig BW, Ames FC and Babiera GV: Timing of surgical intervention for the intact primary in stage IV breast cancer patients. Ann Surg Oncol. 15:1696–1702. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Cady B, Nathan NR, Michaelson JS, Golshan M and Smith BL: Matched pair analyses of stage IV breast cancer with or without resection of primary breast site. Ann Surg Oncol. 15:3384–3395. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Soran A, Özbaş S, Doğan L, Sezgin E, Özmen V, Beriwal S and Brufsky A: Loco-regional treatment for intact primary tumor in patient with de novo metastatic breast cancer; comments and concerns of ECOG-ACRIN 2108 trial. Eur J Breast Health. 16:158–159. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Poggio F, Lambertini M and de Azambuja E: Surgery of the primary tumour in patients presenting with de novo metastatic breast cancer: to do or not to do? ESMO Open. 3:e0003242018. View Article : Google Scholar : PubMed/NCBI | |
|
Teshome M: Role of operative management in stage IV breast cancer. Surg Clin North Am. 98:859–868. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Altundag K: Questions about the primary tumor resection for de-novo metastatic breast cancers. Cancer Treat Res Commun. 20:1001312019. View Article : Google Scholar : PubMed/NCBI | |
|
Altundag K: Predictive role of loco-regional radiotherapy among metastatic breast cancer patients who had undergone primary tumor surgery. Breast Cancer Res Treat. 167:3032018. View Article : Google Scholar : PubMed/NCBI | |
|
Gultekin M, Yazici O, Eren G, Yuce D, Aksoy S, Ozisik Y, Guler N, Yazici G, Hurmuz P, Yildiz F, et al: Impact of locoregional treatment on survival in patients presented with metastatic breast carcinoma. Breast. 23:775–783. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kim YJ, Jung SY and Kim K: Survival benefit of radiotherapy after surgery in de novo stage IV breast cancer: A population-based propensity-score matched analysis. Sci Rep. 9:85272019. View Article : Google Scholar : PubMed/NCBI | |
|
Tan Y, Li X, Chen H, Hu Y, Jiang M, Fu J, Yuan Y and Ding K: Hormone receptor status may impact the survival benefit of surgery in stage IV breast cancer: A population-based study. Oncotarget. 7:70991–71000. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang K, Shi Y, Li ZY, Xiao YL, Li J, Zhang X and Li HY: Metastatic pattern discriminates survival benefit of primary surgery for de novo stage IV breast cancer: A real-world observational study. Eur J Surg Oncol. 45:1364–1372. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Samiee S, Berardi P, Bouganim N, Vandermeer L, Arnaout A, Dent S, Mirsky D, Chasen M, Caudrelier JM and Clemons M: Excision of the primary tumour in patients with metastatic breast cancer: A clinical dilemma. Curr Oncol. 19:e270–e279. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Rashaan ZM, Bastiaannet E, Portielje JE, van de Water W, van der Velde S, Ernst MF, van de Velde CJ and Liefers GJ: Surgery in metastatic breast cancer: Patients with a favorable profile seem to have the most benefit from surgery. Eur J Surg Oncol. 38:52–56. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Retsky M, Bonadonna G, Demicheli R, Folkman J, Hrushesky W and Valagussa P: Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients. Breast Cancer Res. 6:R372–E374. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hofer SO, Molema G, Hermens RA, Wanebo HJ, Reichner JS and Hoekstra HJ: The effect of surgical wounding on tumour development. Eur J Surg Oncol. 25:231–243. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH and Folkman J: Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:315–328. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Gunduz N, Fisher B and Saffer EA: Effect of surgical removal on the growth and kinetics of residual tumor. Cancer Res. 39:3861–3865. 1979.PubMed/NCBI | |
|
Rashid OM and Takabe K: Does removal of the primary tumor in metastatic breast cancer improve survival? J Womens Health (Larchmt). 23:184–188. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cacho-Díaz B, García-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sánchez E and Herrera-Montalvo LA: Tumor microenvironment differences between primary tumor and brain metastases. J Transl Med. 18:12020. View Article : Google Scholar : PubMed/NCBI | |
|
Khodari W, Sedrati A, Naisse I, Bosc R and Belkacemi Y; AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa; www.aromecancer.org), : Impact of loco-regional treatment on metastatic breast cancer outcome: A review. Crit Rev Oncol Hematol. 87:69–79. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R and Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 449:557–563. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Trovato R, Canè S, Petrova V, Sartoris S, Ugel S and De Sanctis F: The engagement between MDSCs and metastases: Partners in crime. Front Oncol. 10:1652020. View Article : Google Scholar : PubMed/NCBI | |
|
Moserle L, Amadori A and Indraccolo S: The angiogenic switch: Implications in the regulation of tumor dormancy. Curr Mol Med. 9:935–941. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kazerounian S and Lawler J: Integration of pro- and anti-angiogenic signals by endothelial cells. J Cell Commun Signal. 12:171–179. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kozłowski J, Kozłowska A and Kocki J: Breast cancer metastasis-insight into selected molecular mechanisms of the phenomenon. Postepy Hig Med Dosw (Online). 69:447–451. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Nguyen DH and Truong PT: A debate on locoregional treatment of the primary tumor in patients presenting with stage IV breast cancer. Expert Rev Anticancer Ther. 11:1913–1922. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Pantel K and Speicher MR: The biology of circulating tumor cells. Oncogene. 35:1216–1224. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang WC and Zhang XF, Peng J, Li XF, Wang AL, Bie YQ, Shi LH, Lin MB and Zhang XF: Survival mechanisms and influence factors of circulating tumor cells. Biomed Res Int. 2018:63047012018. View Article : Google Scholar : PubMed/NCBI | |
|
Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H and Lyden D: Extracellular vesicles in cancer: Cell-to-cell mediators of metastasis. Cancer Cell. 30:836–848. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Dos Anjos Pultz B, Andrés Cordero da Luz F, Socorro Faria S, Peixoto Ferreira de Souza L, Cristina Brígido Tavares P, Alonso Goulart V, Fontes W, Ricardo Goulart L and José Barbosa Silva M: The multifaceted role of extracellular vesicles in metastasis: Priming the soil for seeding. Int J Cancer. 140:2397–2407. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wortzel I, Dror S, Kenific CM and Lyden D: Exosome-mediated metastasis: Communication from a distance. Dev Cell. 49:347–360. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, et al: Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA. 108:16369–16374. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Noguchi M, Nakano Y, Noguchi M, Ohno Y and Kosaka T: Local therapy and survival in breast cancer with distant metastases. J Surg Oncol. 105:104–110. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yousefi M, Nosrati R, Salmaninejad A, Dehghani S, Shahryari A and Saberi A: Organ-specific metastasis of breast cancer: Molecular and cellular mechanisms underlying lung metastasis. Cell Oncol (Dordr). 41:123–140. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sun S and Qiu XS: Cancer stem cells and tumor metastasis. J Cancer Res Ther. 9 (Suppl):S150–S152. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Marcuzzi E, Angioni R, Molon B and Calì B: chemokines and chemokine receptors: Orchestrating tumor metastasization. Int J Mol Sci. 20:962018. View Article : Google Scholar : PubMed/NCBI | |
|
O'Hayre M, Salanga CL, Handel TM and Allen SJ: Chemokines and cancer: Migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J. 409:635–649. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ma R, Feng Y, Lin S, Chen J, Lin H, Liang X, Zheng H and Cai X: Mechanisms involved in breast cancer liver metastasis. J Transl Med. 13:642015. View Article : Google Scholar : PubMed/NCBI | |
|
Seguin L, Desgrosellier JS, Weis SM and Cheresh DA: Integrins and cancer: Regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 25:234–240. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Naxerova K and Jain RK: Using tumour phylogenetics to identify the roots of metastasis in humans. Nat Rev Clin Oncol. 12:258–272. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Norton L and Massagué J: Is cancer a disease of self-seeding? Nat Med. 12:875–878. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Danna EA, Sinha P, Gilbert M, Clements VK, Pulaski BA and Ostrand-Rosenberg S: Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res. 64:2205–2211. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Criscitiello C, Giuliano M, Curigliano G, De Laurentiis M, Arpino G, Carlomagno N, De Placido S, Golshan M and Santangelo M: Surgery of the primary tumor in de novo metastatic breast cancer: To do or not to do? Eur J Surg Oncol. 41:1288–1292. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang ZF, Cristofanilli M, Shao ZM, Tong ZS, Song EW, Wang XJ, Liao N, Hu XC, Liu Y, Wang Y, et al: Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-positive or triple-negative (CBCSG004): A multicenter, double-blind, prospective trial. Ann Oncol. 24:2766–2772. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LWMM and Hayes DF: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 351:781–791. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hazard HW, Gorla SR, Scholtens D, Kiel K, Gradishar WJ and Khan SA: Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer. Cancer. 113:2011–2019. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Dauplat J, Le Bouëdec G, Pomel C and Scherer C: Cytoreductive surgery for advanced stages of ovarian cancer. Semin Surg Oncol. 19:42–48. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Dooley WC: A surgical indication in incurable breast cancer. Ann Surg Oncol. 13:759–760. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Ruiterkamp J, Ernst MF, van de Poll-Franse LV, Bosscha K, Tjan-Heijnen VC and Voogd AC: Surgical resection of the primary tumour is associated with improved survival in patients with distant metastatic breast cancer at diagnosis. Eur J Surg Oncol. 35:1146–1151. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Leung AM, Vu HN, Nguyen KA, Thacker LR and Bear HD: Effects of surgical excision on survival of patients with stage IV breast cancer. J Surg Res. 161:83–88. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Pathy NB, Verkooijen HM, Taib NA, Hartman M and Yip CH: Impact of breast surgery on survival in women presenting with metastatic breast cancer. Br J Surg. 98:1566–1572. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bertaut A, Mounier M, Desmoulins I, Guiu S, Beltjens F, Darut-Jouve A, Ponnelle T, Arnould L and Arveux P: Stage IV breast cancer: A population-based study about prognostic factors according to HER2 and HR status. Eur J Cancer Care (Engl). 24:920–928. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lopez-Tarruella S, Escudero MJ, Pollan M, Martín M, Jara C, Bermejo B, Guerrero-Zotano A, García-Saenz J, Santaballa A, Alba E, et al: Survival impact of primary tumor resection in de novo metastatic breast cancer patients (GEICAM/El Alamo Registry). Sci Rep. 9:200812019. View Article : Google Scholar : PubMed/NCBI | |
|
Pons-Tostivint E, Kirova Y, Lusque A, Campone M, Geffrelot J, Rivera S, Mailliez A, Pasquier D, Madranges N, Firmin N, et al: Radiation therapy to the primary tumor for de novo metastatic breast cancer and overall survival in a retrospective multicenter cohort analysis. Radiother Oncol. 145:109–116. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Rosche M, Regierer AC, Schwarzlose-Schwarck S, Weigel A, Bangemann N, Schefe JH, Scholz CW, Possinger K and Eucker J: Primary tumor excision in stage IV breast cancer at diagnosis without influence on survival: A retrospective analysis and review of the literature. Onkologie. 34:607–612. 2011. View Article : Google Scholar : PubMed/NCBI |
