Hedgehog pathway and cancer: A new area (Review)
- Authors:
- Deyi Shen
- Yuwei Xia
- Yuhan Fu
- Qiaochang Cao
- Wenqian Chen
- Ying Zhu
- Kaibo Guo
- Leitao Sun
-
Affiliations: The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, P.R. China, The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Cancer Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China - Published online on: July 10, 2024 https://doi.org/10.3892/or.2024.8775
- Article Number: 116
-
Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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 |
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|
Clara JA, Monge C, Yang Y and Takebe N: Targeting signalling pathways and the immune microenvironment of cancer stem cells-a clinical update. Nat Rev Clin Oncol. 17:204–232. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Girardi D, Barrichello A, Fernandes G and Pereira A: Targeting the hedgehog pathway in cancer: Current evidence and future perspectives. Cells. 8:1532019. View Article : Google Scholar : PubMed/NCBI | |
|
Niyaz M, Khan MS and Mudassar S: Hedgehog signaling: An Achilles' Heel in cancer. Transl Oncol. 12:1334–1344. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jeng KS, Chang CF and Lin SS: Sonic hedgehog signaling in organogenesis, tumors, and tumor microenvironments. Int J Mol Sci. 21:7582020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou M and Jiang J: Gli phosphorylation code in hedgehog signal transduction. Front Cell Dev Biol. 10:8469272022. View Article : Google Scholar : PubMed/NCBI | |
|
Xin M, Ji X, De La Cruz LK, Thareja S and Wang B: Strategies to target the Hedgehog signaling pathway for cancer therapy. Med Res Rev. 38:870–913. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR and Riobo NA: Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem. 286:19589–19596. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Suchors C and Kim J: Canonical hedgehog pathway and noncanonical GLI transcription factor activation in cancer. Cells. 11:25232022. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D: Hallmarks of cancer: New dimensions. Cancer Discov. 12:31–46. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Kim BR, Na YJ, Kim JL, Jeong YA, Park SH, Jo MJ, Jeong S, Kang S, Oh SC and Lee DH: RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer. Cell Death Differ. 27:676–694. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xia Y, Zhen L, Li H, Wang S, Chen S, Wang C and Yang X: MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway. Cell Death Dis. 12:3262021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L, Li Y, Song Z, Xue S, Liu F, Chang X, Wu Y, Duan X and Wu H: O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling. Proc Natl Acad Sci USA. 119:e22028211192022. View Article : Google Scholar : PubMed/NCBI | |
|
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD and Jhanwar-Uniyal M: Molecular stratification of medulloblastoma: Clinical outcomes and therapeutic interventions. Anticancer Res. 42:2225–2239. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Fan Z, Li J, Du J, Zhang H, Shen Y, Wang CY and Wang S: A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family. J Med Genet. 45:303–308. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Smith MJ and Evans DG: PTCH2 is not a strong candidate gene for gorlin syndrome predisposition. Fam Cancer. 21:343–346. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Guerrini-Rousseau L, Masliah-Planchon J, Waszak SM, Alhopuro P, Benusiglio PR, Bourdeaut F, Brecht IB, Del Baldo G, Dhanda SK, Garrè ML, et al: Cancer risk and tumour spectrum in 172 patients with a germline SUFU pathogenic variation: A collaborative study of the SIOPE Host Genome Working Group. J Med Genet. 59:1123–1132. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Bansaccal N, Vieugue P, Sarate R, Song Y, Minguijon E, Miroshnikova YA, Zeuschner D, Collin A, Allard J, Engelman D, et al: The extracellular matrix dictates regional competence for tumour initiation. Nature. 623:828–835. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Nicheperovich A and Townsend-Nicholson A: Towards precision oncology: The role of smoothened and its variants in cancer. J Pers Med. 12:16482022. View Article : Google Scholar : PubMed/NCBI | |
|
Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh MT, Lu YJ and Philpott MP: GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis. Cell Death Dis. 5:e10282014. View Article : Google Scholar : PubMed/NCBI | |
|
Kerr DA, Cloutier JM, Margolis M, Mata DA, Rodrigues Simoes NJ, Faquin WC, Dias-Santagata D, Chopra S, Charville GW, Wangsiricharoen S, et al: GLI1-altered mesenchymal tumors with ACTB or PTCH1 fusion: A molecular and clinicopathologic analysis. Mod Pathol. 37:1003862024. View Article : Google Scholar : PubMed/NCBI | |
|
Xu B, Chang K, Folpe AL, Kao YC, Wey SL, Huang HY, Gill AJ, Rooper L, Bishop JA, Dickson BC, et al: Head and neck mesenchymal neoplasms with GLI1 Gene alterations: A pathologic entity with distinct histologic features and potential for distant metastasis. Am J Surg Pathol. 44:729–737. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Agaram NP, Zhang L, Sung YS, Singer S, Stevens T, Prieto-Granada CN, Bishop JA, Wood BA, Swanson D, Dickson BC and Antonescu CR: GLI1-amplifications expand the spectrum of soft tissue neoplasms defined by GLI1 gene fusions. Mod Pathol. 32:1617–1626. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Dawson MA and Kouzarides T: Cancer epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Zhang H and Gao P: Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell. 13:877–919. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Z, Zhou Q, Sun Y, Lai F, Wang Z, Hao Z and Li G: MethMarkerDB: A comprehensive cancer DNA methylation biomarker database. Nucleic Acids Res. 52:D1380–D1392. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Duan ZH, Wang HC, Zhao DM, Ji XX, Song M, Yang XJ and Cui W: Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer. Cancer Sci. 106:1084–1091. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Garcia N, Al-Hendy A, Baracat EC, Carvalho KC and Yang Q: Targeting hedgehog pathway and DNA methyltransferases in uterine leiomyosarcoma cells. Cells. 10:532020. View Article : Google Scholar : PubMed/NCBI | |
|
Lou H, Li H, Huehn AR, Tarasova NI, Saleh B, Anderson SK and Dean M: Genetic and epigenetic regulation of the smoothened gene (SMO) in cancer cells. Cancers (Basel). 12:22192020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang TP, Hsu SH, Feng HC and Huang RF: Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway. Carcinogenesis. 33:1158–1168. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Bongiovanni D, Tosello V, Saccomani V, Dalla Santa S, Amadori A, Zanovello P and Piovan E: Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemia. Oncogene. 39:6544–6555. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yan Z, Cheng M, Hu G, Wang Y, Zeng S, Huang A, Xu L, Liu Y, Shi C, Deng L, et al: Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth. Cell Death Dis. 12:1992021. View Article : Google Scholar : PubMed/NCBI | |
|
Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I and Gulino A: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol. 8:1415–1423. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Liao H, Cai J, Liu C, Shen L, Pu X, Yao Y, Han B, Yu T, Cheng SY and Yue S: Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused. Cell Death Dis. 11:6862020. View Article : Google Scholar : PubMed/NCBI | |
|
Hu L, Cao H, Zheng L and Li R: BBOX1-AS1 activates hedgehog signaling pathway to facilitate the proliferation and stemness of esophageal squamous cell carcinoma cells via miR-506-5p/EIF5A/PTCH1 axis. Curr Mol Pharmacol. 16:894–904. 2023.PubMed/NCBI | |
|
Bartl J, Zanini M, Bernardi F, Forget A, Blümel L, Talbot J, Picard D, Qin N, Cancila G, Gao Q, et al: The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun. 13:40612022. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, Xie J, Jiang X, Wei S and Lin C: LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA. Life Sci. 321:1215782023. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Cheng Y, Mou Y, Tang X and Mu X: Natural antisense long noncoding RNA HHIP-AS1 suppresses Non-small-cell lung cancer progression by increasing HHIP stability via interaction with CELF2. Crit Rev Eukaryot Gene Expr. 33:67–77. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Wu Y, Xiao Z, Liu Y, Wang C, Zhou L and Yang X: Long non-coding RNA HIF1A-AS2 promotes carcinogenesis by enhancing Gli1-mediated HIF1α expression in clear cell renal cell carcinoma. Pathol Res Pract. 253:1549842024. View Article : Google Scholar : PubMed/NCBI | |
|
Xu F, Li H and Hu C: LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer. Biosci Rep. 39:BSR201805512019. View Article : Google Scholar : PubMed/NCBI | |
|
Wu J, Zhou F, Lai S, Wang W, Wu T, Liu Y and Yang L: Propofol inhibits biological function of hepatocellular carcinoma cells through LINC00475-mediated sonic hedgehog pathway. Pharmacology. 108:127–137. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Meng D, Zhao S, Wu L, Ma X, Zhao D and Li Z: LINC00641 impeded the malignant biological behaviors of papillary thyroid carcinoma cells via interacting with IGF2BP1 to reduce GLI1 mRNA stability. Hum Exp Toxicol. 42:96032712311808562023. View Article : Google Scholar : PubMed/NCBI | |
|
He J, Zuo Q, Hu B, Jin H, Wang C, Cheng Z, Deng X, Yang C, Ruan H, Yu C, et al: A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA. Cancer Lett. 450:98–109. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Guo K, Gong W, Wang Q, Gu G, Zheng T, Li Y, Li W, Fang M, Xie H, Yue C, et al: LINC01106 drives colorectal cancer growth and stemness through a positive feedback loop to regulate the Gli family factors. Cell Death Dis. 11:8692020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Yin Z, Xu L, Liu H, Jiang L, Liu S and Sun X: Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway. Cell Death Dis. 12:1732021. View Article : Google Scholar : PubMed/NCBI | |
|
Wei P, Jiang J, Xiao M, Zeng M, Liu X, Zhao B and Chen F: The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation. Exp Cell Res. 412:1130092022. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Wang XJ and Jin JH: SOX2-induced upregulation of lncRNA LINC01510 promotes papillary thyroid carcinoma progression by modulating miR-335/SHH and activating Hedgehog pathway. Biochem Biophys Res Commun. 520:277–283. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Nie H, Liao Z, Wang Y, Zhou J, He X and Ou C: Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology. Genes Dis. 8:769–780. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Guo L, Zhou Y, Chen Y, Sun H, Wang Y and Qu Y: LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway. Biomed Pharmacother. 103:167–173. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, He P, Xie D, Wang J and Wan C: Long-noncoding RNA ANCR activates the hedgehog signaling pathway to promote basal cell carcinoma progression by binding to PTCH. Clin Cosmet Investig Dermatol. 15:955–965. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Chen F, Mo J and Zhang L: Long noncoding RNA BCAR4 promotes osteosarcoma progression through activating GLI2-dependent gene transcription. Tumour Biol. 37:13403–13412. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang H, Yan L, Sun K, Sun X, Zhang X, Cai K and Song T: lncRNA BCAR4 increases viability, invasion, and migration of Non-small cell lung cancer cells by targeting glioma-associated oncogene 2 (GLI2). Oncol Res. 27:359–369. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sun J, Jia J, Yuan W, Liu S, Wang W, Ge L, Ge L and Liu XJ: LncRNA BLACAT1 accelerates Non-small cell lung cancer through up-regulating the activation of sonic hedgehog pathway. Front Oncol. 11:6252532021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou H, Xiong Y, Peng L, Wang R, Zhang H and Fu Z: LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway. J Cell Biochem. 121:2510–2524. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Song L, Ye Y and Li W: Long noncoding RNA DIO3OS hinders cell malignant behaviors of hepatocellular carcinoma cells through the microRNA-328/Hhip axis. Cancer Manag Res. 12:3903–3914. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu S, Chen G, Peng J, Liu J, Chen J, Wang J, Li L and Yang K: LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway. FEBS Open Bio. 10:817–826. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Peng W, Wu J, Fan H, Lu J and Feng J: LncRNA EGOT promotes tumorigenesis via hedgehog pathway in gastric cancer. Pathol Oncol Res. 25:883–887. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng S, Li M, Miao K and Xu H: lncRNA GAS5-promoted apoptosis in triple-negative breast cancer by targeting miR-378a-5p/SUFU signaling. J Cell Biochem. 121:2225–2235. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Ma TT, Ma YH and Jiang YF: LncRNA HCG18 contributes to nasopharyngeal carcinoma development by modulating miR-140/CCND1 and Hedgehog signaling pathway. Eur Rev Med Pharmacol Sci. 23:10387–10399. 2019.PubMed/NCBI | |
|
Wu J, Zhu P, Lu T, Du Y, Wang Y, He L, Ye B, Liu B, Yang L, Wang J, et al: The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling. J Hepatol. 70:918–929. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bai JY, Jin B, Ma JB, Liu TJ, Yang C, Chong Y, Wang X, He D and Guo P: HOTAIR and androgen receptor synergistically increase GLI2 transcription to promote tumor angiogenesis and cancer stemness in renal cell carcinoma. Cancer Lett. 498:70–79. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Lu G, Zhong H, Gao J and Zhang Y: Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance. J Biomater Appl. 38:877–889. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou M, Hou Y, Yang G, Zhang H, Tu G, Du YE, Wen S, Xu L, Tang X, Tang S, et al: LncRNA-Hh strengthen cancer stem cells generation in Twist-positive breast cancer via activation of hedgehog signaling pathway. Stem Cells. 34:55–66. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Chen Z, Li MJ, Guo HY and Jing NC: Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 regulates the expression of Gli2 by miR-202 to strengthen gastric cancer progression. Biomed Pharmacother. 85:264–271. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Hamada T, Higashi M, Yokoyama S, Akahane T, Hisaoka M, Noguchi H, Furukawa T and Tanimoto A: MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer. BMC Cancer. 23:4242023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Wang F, Yu X, Qi J, Dong H, Cui B, Zhang Q, Wu Y, An J, Ni N, et al: LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression. Oncogene. 43:1328–1340. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Qian CS, Li LJ, Huang HW, Yang HF and Wu DP: MYC-regulated lncRNA NEAT1 promotes B cell proliferation and lymphomagenesis via the miR-34b-5p-GLI1 pathway in diffuse large B-cell lymphoma. Cancer Cell Int. 20:872020. View Article : Google Scholar : PubMed/NCBI | |
|
Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y, Cui B, Qi J, Zhang X, Liu C, et al: N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness. Cell Death Discov. 9:1492023. View Article : Google Scholar : PubMed/NCBI | |
|
Herrera-Solorio AM, Peralta-Arrieta I, Armas López L, Hernández-Cigala N, Mendoza Milla C, Ortiz Quintero B, Catalán Cárdenas R, Pineda Villegas P, Rodríguez Villanueva E, Trejo Iriarte CG, et al: LncRNA SOX2-OT regulates AKT/ERK and SOX2/GLI-1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases. Mol Oncol. 15:1110–1129. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Zhang Q, Fan X, Mo W, Dai W, Feng J, Wu L, Liu T, Li S, Xu S, et al: The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma. Oncotarget. 8:65932–65945. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Liang H, Zhang J, Yang Y, Ling X and Jiang H: Long non-coding RNA SNHG16 facilitates esophageal cancer cell proliferation and Self-renewal through the microRNA-802/PTCH1 axis. Curr Med Chem. 29:6084–6099. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Ye G, Pan R, Zhu L and Zhou D: Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway. Exp Mol Pathol. 116:1044922020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Yu L, Yan J, Xiao Y, Li W, Xiao J, Lei J, Xiang D, Zhang S and Yu X: Circular RNA DGKB promotes the progression of neuroblastoma by targeting miR-873/GLI1 axis. Front Oncol. 10:11042020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Y, Xue X, Luo J, Li P, Xiao Z, Zhang W, Zhou J, Li P, Zhao J, Ge H, et al: Circular RNA circ-FIRRE interacts with HNRNPC to promote esophageal squamous cell carcinoma progression by stabilizing GLI2 mRNA. Cancer Sci. 114:3608–3622. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Song J, Liu Y, Zhou Z and Wang X: Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2. J Exp Clin Cancer Res. 39:1012020. View Article : Google Scholar : PubMed/NCBI | |
|
Wu B, Xia L, Zhang S, Jin K, Li L, Sun C, Xia T and Chen G: circRNA-SMO upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326. Histol Histopathol. 38:1307–1319. 2023.PubMed/NCBI | |
|
Wu X, Xiao S, Zhang M, Yang L, Zhong J, Li B, Li F, Xia X, Li X, Zhou H, et al: A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity. Genome Biol. 22:332021. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong Z, Zhou C, Wang L, Zhu R, Zhong L, Wan D and Wang Q: Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO. Aging (Albany NY). 11:12345–12360. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Xia J, Yang J, Shi Y, Xia H, Xiang X and Yu X: Circ-ZNF609 promotes migration of colorectal cancer by inhibiting Gli1 expression via microRNA-150. J BUON. 23:1343–1349. 2018.PubMed/NCBI | |
|
He Y, Huang H, Jin L, Zhang F, Zeng M, Wei L, Tang S, Chen D and Wang W: CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. Cell Death Dis. 11:3582020. View Article : Google Scholar : PubMed/NCBI | |
|
Ye G, He S, Pan R, Zhu L, Zhou D, Cai G and Chen P: circ_0041732 promotes breast cancer progression. Mol Cancer Res. 20:1561–1573. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Li B, Yi X, Xiao X, Zheng Q and Ma L: Circ_0036412 affects the proliferation and cell cycle of hepatocellular carcinoma via hedgehog signaling pathway. J Transl Med. 20:1542022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang P, Gao H, Yan R, Yu L, Xia C and Yang D: has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway. Cancer Sci. 114:1491–1506. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Seidl C, Panzitt K, Bertsch A, Brcic L, Schein S, Mack M, Leithner K, Prinz F, Olschewski H, Kornmueller K and Hrzenjak A: MicroRNA-182-5p regulates hedgehog signaling pathway and chemosensitivity of cisplatin-resistant lung adenocarcinoma cells via targeting GLI2. Cancer Lett. 469:266–276. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Wang C, Liu T, Tang Z, Yan R, Zhang C, Cheng C, Wang J, Wang H, Huang H and Li Y: miRNA-182-5p promotes human bladder cancer proliferation and migration through the FOXF2/SHH axis. Neoplasma. 69:321–330. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Zhang D, Chen C, Ruan Z, Li Y and Huang Y: MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1. Mol Biol Cell. 23:1423–1434. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chen LT, Xu SD, Xu H, Zhang JF, Ning JF and Wang SF: MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. Med Oncol. 29:1673–1680. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xin L, Liu L, Liu C, Zhou LQ, Zhou Q, Yuan YW, Li SH and Zhang HT: DNA-methylation-mediated silencing of miR-7-5p promotes gastric cancer stem cell invasion via increasing Smo and Hes1. J Cell Physiol. 235:2643–2654. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, Cheng Y, Yang M, Wang Q, Feng X, et al: MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett. 385:117–127. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Y, Zhang X, Lin H, Deng S, Qin Y, He J, Hu F, Zhu X, Feng X, Wang J, et al: Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer. Aging (Albany NY). 13:10749–10769. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HQ, Sun Y, Li JQ, Huang LM, Tan SS, Yang FY and Li H: The expression of microRNA-324-3p as a tumor suppressor in nasopharyngeal carcinoma and its clinical significance. Onco Targets Ther. 10:4935–4943. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Y, Zhang X, Lin H, Deng S, Qin Y, Yuan Y, Feng X, Wang J, Chen W, Hu F, et al: SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer. Cell Cycle. 19:2720–2733. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu HS, Zong HL, Shang M, Ming X, Zhao JP, Ma C and Cao L: MiR-324-5p inhibits proliferation of glioma by target regulation of GLI1. Eur Rev Med Pharmacol Sci. 18:828–832. 2014.PubMed/NCBI | |
|
Ysrafil Y and Astuti I: Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression. Bioimpacts. 12:195–202. 2022.PubMed/NCBI | |
|
Tang B, Xu A, Xu J, Huang H, Chen L, Su Y, Zhang L, Li J, Fan F, Deng J, et al: MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling. Int J Cancer. 142:109–120. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rodríguez-García Y, Martínez-Moreno M, Alonso L, Sánchez-Vencells A, Arranz A, Dagà-Millán R, Sevilla-Movilla S, Valeri A, Martínez-López J and Teixidó J: Regulation of miRNA expression by α4β1 integrin-dependent multiple myeloma cell adhesion. EJHaem. 4:631–638. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Y, Qin Y, Zhang X, Deng S, Yuan Y, Feng X, Chen W, Hu F, Gao Y, He J, et al: MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT. Heliyon. 7:e066952021. View Article : Google Scholar : PubMed/NCBI | |
|
Yang H, Fu H, Wang B, Zhang X, Mao J, Li X, Wang M, Sun Z, Qian H and Xu W: Exosomal miR-423-5p targets SUFU to promote cancer growth and metastasis and serves as a novel marker for gastric cancer. Mol Carcinog. 57:1223–1236. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tang CT, Liang Q, Yang L, Lin XL, Wu S, Chen Y, Zhang XT, Gao YJ and Ge ZZ: RAB31 Targeted by MiR-30c-2-3p Regulates the GLI1 signaling pathway, affecting gastric cancer cell proliferation and apoptosis. Front Oncol. 8:5542018. View Article : Google Scholar : PubMed/NCBI | |
|
Cao D, Yu T and Ou X: MiR-873-5P controls gastric cancer progression by targeting hedgehog-GLI signaling. Pharmazie. 71:603–606. 2016.PubMed/NCBI | |
|
Zhou Y, Tang X, Huang Z, Wen J, Xiang Q and Liu D: KLF5 promotes KIF1A expression through transcriptional repression of microRNA-338 in the development of pediatric neuroblastoma. J Pediatr Surg. 57:192–201. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Sun K, Deng HJ, Lei ST, Dong JQ and Li GX: miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. World J Gastroenterol. 19:2197–2207. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao DW, Hou YS, Sun FB, Han B and Li SJ: Effects of miR-132 on proliferation and apoptosis of pancreatic cancer cells via Hedgehog signaling pathway. Eur Rev Med Pharmacol Sci. 23:1978–1985. 2019.PubMed/NCBI | |
|
Du W, Liu X, Chen L, Dou Z, Lei X, Chang L, Cai J, Cui Y, Yang D, Sun Y, et al: Targeting the SMO oncogene by miR-326 inhibits glioma biological behaviors and stemness. Neuro Oncol. 17:243–253. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Huang JH, Xu Y and Lin FY: The inhibition of microRNA-326 by SP1/HDAC1 contributes to proliferation and metastasis of osteosarcoma through promoting SMO expression. J Cell Mol Med. 24:10876–10888. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Babashah S, Sadeghizadeh M, Hajifathali A, Tavirani MR, Zomorod MS, Ghadiani M and Soleimani M: Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells. Int J Cancer. 133:579–589. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Sheybani Z, Rahgozar S and Ghodousi ES: The Hedgehog signal transducer Smoothened and microRNA-326: Pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia. Cancer Manag Res. 11:7621–7630. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X and Jiang C: MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway. Cancer Biol Ther. 19:260–270. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, et al: β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells. BMC Cancer. 17:4882017. View Article : Google Scholar : PubMed/NCBI | |
|
Munoz JL, Rodriguez-Cruz V, Ramkissoon SH, Ligon KL, Greco SJ and Rameshwar P: Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level. Oncotarget. 6:1190–1201. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang YF, Yang HY, Shi XQ and Wang Y: Upregulation of microRNA-129-5p inhibits cell invasion, migration and tumor angiogenesis by inhibiting ZIC2 via downregulation of the Hedgehog signaling pathway in cervical cancer. Cancer Biol Ther. 19:1162–1173. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Feng J and Zhang A: miR-584 inhibits cell proliferation, migration and invasion in vitro and enhances the sensitivity to cisplatin in human cervical cancer by negatively targeting GLI1. Exp Ther Med. 19:2059–2066. 2020.PubMed/NCBI | |
|
Guan B, Mu L, Zhang L, Wang K, Tian J, Xu S, Wang X, He D and Du Y: MicroRNA-218 inhibits the migration, epithelial-mesenchymal transition and cancer stem cell properties of prostate cancer cells. Oncol Lett. 16:1821–1826. 2018.PubMed/NCBI | |
|
Zhang J, Li S, Li Y, Liu H, Zhang Y and Zhang Q: miRNA-218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. Exp Ther Med. 16:2433–2441. 2018.PubMed/NCBI | |
|
Wen SY, Lin Y, Yu YQ, Cao SJ, Zhang R, Yang XM, Li J, Zhang YL, Wang YH, Ma MZ, et al: miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. Oncogene. 34:717–725. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Z, Zhang T, Hong H, Liu Q and Zhang H: miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2. Mol Cell Biochem. 397:277–283. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Z, Huang C and Hao D: MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway. Oncol Rep. 37:1261–1269. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Qiu M, An Y, Huang J and Gong C: miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3. Biochem Biophys Res Commun. 503:2101–2107. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Miao X, Gao H, Liu S, Chen M, Xu W, Ling X, Deng X and Rao C: Down-regulation of microRNA-224-inhibites growth and epithelial-to-mesenchymal transition phenotype-via modulating SUFU expression in bladder cancer cells. Int J Biol Macromol. 106:234–240. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao D and Cui Z: MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling. Exp Ther Med. 17:1154–1162. 2019.PubMed/NCBI | |
|
Su YC, Metzen LT, Vélez LM, Bournique E, Seldin M, Buisson R, Kuo WW, Huang CY and Kaiser P: Induction of resistance to oxaliplatin in cancer by a microRNA/Fem1B/Gli1 pathway. Am J Cancer Res. 13:6011–6025. 2023.PubMed/NCBI | |
|
Zheng J, Cheng C, Xu J, Gao P, Wang J and Chen L: miR-142-3p regulates tumor cell autophagy and promotes colon cancer progression by targeting TP53INP2. Chemotherapy. 67:57–66. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Huang X, Zhang G, Chen Z, Guan H and Zhou W: Tumor suppressor miR-361-3p inhibits prostate cancer progression through Gli1 and AKT/mTOR signaling pathway. Cell Signal. 114:1109982024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Li Y, Ren Y, Han H and Li J: Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway. Genes Genomics. 44:981–991. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Rashid S, Rashid S, Das P, Malik N, Dash NR, Singh N, Pandey RM, Kumar L, Chauhan SS, Chosdol K, et al: Elucidating the role of miRNA-326 modulating hedgehog signaling in pancreatic carcinoma. Pancreas. 53:e42–e48. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Xu X, Li Y, Liu G, Li K, Chen P, Gao Y, Liang W, Xi H, Wang X, Wei B, et al: MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2. Cancer Biol Med. 19:1662–1682. 2022.PubMed/NCBI | |
|
Chang W, Chang Q, Lu H, Li Y and Chen C: MiR-221-3p facilitates thyroid cancer cell proliferation and inhibit apoptosis by targeting FOXP2 through hedgehog pathway. Mol Biotechnol. 64:919–927. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Hong XL, Yu TC, Huang XW, Wang JL, Sun TT, Yan TT, Zhou CB, Chen HM, Su WY, Du W and Xiong H: Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p/sonic hedgehog signaling-regulated stemness. Br J Cancer. 128:363–374. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, et al: CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy. Cell Rep Med. 4:1008782023. View Article : Google Scholar : PubMed/NCBI | |
|
Ding L, Sheriff S, Sontz RA and Merchant JL: Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases. Front Immunol. 14:11393912023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Kim HG, Dong E, Dong C, Huang M, Liu Y, Liangpunsakul S and Dong XC: Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway. Biochim Biophys Acta Mol Basis Dis. 1865:2685–2693. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bao R, Stapor D and Luke JJ: Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types. Genome Med. 12:902020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Jin G, Li Q, Wang Z, Hu W, Li P, Li S, Wu H, Kong X, Gao J and Li Z: Hedgehog signaling Non-canonical activated by pro-inflammatory cytokines in pancreatic ductal adenocarcinoma. J Cancer. 7:2067–2076. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ding J, Li HY, Zhang L, Zhou Y and Wu J: Hedgehog signaling, a critical pathway governing the development and progression of hepatocellular carcinoma. Cells. 10:1232021. View Article : Google Scholar : PubMed/NCBI | |
|
Chang WH, Forde D and Lai AG: A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers. J Transl Med. 17:142019. View Article : Google Scholar : PubMed/NCBI | |
|
Chang WH and Lai AG: Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion. Br J Cancer. 121:666–678. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Fan J, Zeng X, Nie M, Luan J, Wang Y, Ju D and Yin K: Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment. Acta Pharm Sin B. 11:609–620. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, et al: Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma. Int J Cancer. 143:2943–2954. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Laner-Plamberger S, Wolff F, Kaser-Eichberger A, Swierczynski S, Hauser-Kronberger C, Frischauf AM and Eichberger T: Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells. PLoS One. 8:e753172013. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, et al: Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proc Natl Acad Sci USA. 113:E7545–E7553. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou X, Liu Z, Jang F, Xiang C, Li Y and He Y: Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10. PLoS One. 7:e441212012. View Article : Google Scholar : PubMed/NCBI | |
|
Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD and Maitra A: Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology. 135:621–631. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Nakamura K and Smyth MJ: Targeting cancer-related inflammation in the era of immunotherapy. Immunol Cell Biol. 95:325–332. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Y, Guo W, Wang T, Liu Y, Mullor MDMR, Rodrìguez RA, Zhao S and Wei R: The comprehensive landscape of prognosis, immunity, and function of the GLI family by pan-cancer and single-cell analysis. Aging (Albany NY). 16:5123–5148. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Lecoultre M, Dutoit V and Walker PR: Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: A review. J Immunother Cancer. 8:e0014082020. View Article : Google Scholar : PubMed/NCBI | |
|
Koh V, Chakrabarti J, Torvund M, Steele N, Hawkins JA, Ito Y, Wang J, Helmrath MA, Merchant JL, Ahmed SA, et al: Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids. Cancer Lett. 518:59–71. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu L, Yang Y, Li H, Xu L, You H, Liu Y, Liu Z, Liu X, Zheng D, Bie J, et al: Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma. Cancer Lett. 535:2156302022. View Article : Google Scholar : PubMed/NCBI | |
|
Grund-Gröschke S, Ortner D, Szenes-Nagy AB, Zaborsky N, Weiss R, Neureiter D, Wipplinger M, Risch A, Hammerl P, Greil R, et al: Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity. Mol Oncol. 14:1930–1946. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hinshaw DC, Hanna A, Lama-Sherpa T, Metge B, Kammerud SC, Benavides GA, Kumar A, Alsheikh HA, Mota M, Chen D, et al: Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages. Cancer Res. 81:5425–5437. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Petty AJ, Li A, Wang X, Dai R, Heyman B, Hsu D, Huang X and Yang Y: Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment. J Clin Invest. 129:5151–5162. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hanna A, Metge BJ, Bailey SK, Chen D, Chandrashekar DS, Varambally S, Samant RS and Shevde LA: Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer. Oncoimmunology. 8:15482412019. View Article : Google Scholar : PubMed/NCBI | |
|
Petty AJ, Dai R, Lapalombella R, Baiocchi RA, Benson DM, Li Z, Huang X and Yang Y: Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function. JCI Insight. 6:e1467072021. View Article : Google Scholar : PubMed/NCBI | |
|
Marcovecchio PM, Thomas G and Salek-Ardakani S: CXCL9-expressing tumor-associated macrophages: New players in the fight against cancer. J Immunother Cancer. 9:e0020452021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Z, Li H, Li Z, Chen S, Huang X, Zheng Z, Qian X, Zhang L, Long G, Xie J, et al: SHH/GLI2-TGF-β1 feedback loop between cancer cells and tumor-associated macrophages maintains epithelial-mesenchymal transition and endoplasmic reticulum homeostasis in cholangiocarcinoma. Pharmacol Res. 187:1065642023. View Article : Google Scholar : PubMed/NCBI | |
|
Holla S, Stephen-Victor E, Prakhar P, Sharma M, Saha C, Udupa V, Kaveri SV, Bayry J and Balaji KN: Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion. Sci Rep. 6:241932016. View Article : Google Scholar : PubMed/NCBI | |
|
Hinshaw DC, Benavides GA, Metge BJ, Swain CA, Kammerud SC, Alsheikh HA, Elhamamsy A, Chen D, Darley-Usmar V, Rathmell JC, et al: Hedgehog signaling regulates treg to Th17 conversion through metabolic rewiring in breast cancer. Cancer Immunol Res. 11:687–702. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Giammona A, Crivaro E and Stecca B: Emerging roles of hedgehog signaling in cancer immunity. Int J Mol Sci. 24:13212023. View Article : Google Scholar : PubMed/NCBI | |
|
Ji W, Niu X, Yu Y, Li Z, Gu L and Lu S: SMO mutation predicts the effect of immune checkpoint inhibitor: From NSCLC to multiple cancers. Front Immunol. 13:9558002022. View Article : Google Scholar : PubMed/NCBI | |
|
Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins JA, Sundaram N, Wroblewski LE, Peek RM Jr, Wang J, Helmrath M, et al: Increased programmed Death-ligand 1 is an early epithelial cell response to Helicobacter pylori Infection. PLoS Pathog. 15:e10074682019. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang J, Ding Y, Chen Y, Lu J, Chen Y, Wu G, Xu N, Wang H and Teng L: Pan-cancer analyses reveal that increased Hedgehog activity correlates with tumor immunosuppression and resistance to immune checkpoint inhibitors. Cancer Med. 11:847–863. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B and Houghton JA: Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PLoS One. 8:e752532013. View Article : Google Scholar : PubMed/NCBI | |
|
Villarinho NJ, Vasconcelos FDC, Mazzoccoli L, da Silva Robaina MC, Pessoa LS, Siqueira PET, Maia RC, de Oliveira DM, Leite de Sampaio E, Spohr TC and Lopes GF: Effects of long-term exposure to MST-312 on lung cancer cells tumorigenesis: Role of SHH/GLI-1 axis. Cell Biol Int. 46:1468–1479. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Bernabé-García M, Martínez-Balsalobre E, García-Moreno D, García-Castillo J, Revilla-Nuin B, Blanco-Alcaina E, Mulero V, Alcaraz-Pérez F and Cayuela ML: Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness. Mol Oncol. 15:1818–1834. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Wang S, Tang B, Tang L, Lei Y, Liu Y, Yang M, Yang G, Zhang D and Liu E: Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis. J Mol Histol. 52:1165–1175. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Sivakumar S, Qi S, Cheng N, Sathe AA, Kanchwala M, Kumar A, Evers BM, Xing C and Yu H: TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 38:1103952022. View Article : Google Scholar : PubMed/NCBI | |
|
Cain JE and Watkins DN: p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis. Mol Cell Oncol. 7:18050952020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Zhang Y, Li K and Xue S: Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance. Front Cell Dev Biol. 11:12571732023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou C, Du J, Zhao L, Liu W, Zhao T, Liang H, Fang P, Zhang K and Zeng H: GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia. Cell Death Dis. 12:2312021. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Y, Wang Y, Fan C, Gao P, Wang X, Wei G and Wei J: Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation. Mol Cancer. 13:1372014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Wang H, Yan Z, Li G, Hu G, Zhang H, Huang D, Wang Y, Zhang X, Yan Y, et al: The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation. Cell Commun Signal. 18:1162020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Hao C, Zhang R, Pei X, Li J and Wang L: A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent manner through inhibiting Notch pathway in multiple myeloma. Cell Cycle. 19:2063–2073. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, Agarwal NK and Vega F: Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma. Blood. 121:4718–4728. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kasperczyk H, Baumann B, Debatin KM and Fulda S: Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. FASEB J. 23:21–33. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Kurita S, Mott JL, Almada LL, Bronk SF, Werneburg NW, Sun SY, Roberts LR, Fernandez-Zapico ME and Gores GJ: GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis. Oncogene. 29:4848–4858. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, et al: Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol. 19:1226–1236. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Fingas CD, Mertens JC, Razumilava N, Sydor S, Bronk SF, Christensen JD, Rizvi SH, Canbay A, Treckmann JW, Paul A, et al: Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma. Hepatology. 58:1362–1374. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Meister MT, Boedicker C, Linder B, Kögel D, Klingebiel T and Fulda S: Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Cancer Lett. 465:1–11. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Trieu KG, Tsai SY, Eberl M, Ju V, Ford NC, Doane OJ, Peterson JK, Veniaminova NA, Grachtchouk M, Harms PW, et al: Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease. Cell Rep. 39:1107792022. View Article : Google Scholar : PubMed/NCBI | |
|
Koeniger A, Brichkina A, Nee I, Dempwolff L, Hupfer A, Galperin I, Finkernagel F, Nist A, Stiewe T, Adhikary T, et al: Activation of Cilia-independent Hedgehog/GLI1 signaling as a novel concept for neuroblastoma therapy. Cancers (Basel). 13:19082021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Huang S, Tian R, Chen J, Gao H, Xie C, Shan Y, Zhang Z, Gu S and Xu M: The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK. Oncotarget. 9:14413–14427. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Azatyan A, Gallo-Oller G, Diao Y, Selivanova G, Johnsen JI and Zaphiropoulos PG: RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism. Cancer Lett. 442:341–350. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Wang J, Lu Y, Zhao Y, Prinz RA and Xu X: Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells. Cell Death Dis. 12:4592021. View Article : Google Scholar : PubMed/NCBI | |
|
Londero AP, Orsaria M, Viola L, Marzinotto S, Bertozzi S, Galvano E, Andreetta C and Mariuzzi L: Survivin, sonic hedgehog, krüppel-like factors, and p53 pathway in serous ovarian cancer: an immunohistochemical study. Hum Pathol. 127:92–101. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Y, Fang Q, Liu W, Liu Y and Zhang C: GANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma. Cell Death Dis. 14:4612023. View Article : Google Scholar : PubMed/NCBI | |
|
Deng H, Huang L, Liao Z, Liu M, Li Q and Xu R: Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells. Cell Death Dis. 11:5392020. View Article : Google Scholar : PubMed/NCBI | |
|
Klingseisen V, Slanovc J, Regouc M and Hrzenjak A: Bisdemethoxycurcumin sensitizes the response of cisplatin resistant non-small cell lung carcinoma cell lines by activating apoptosis and autophagy. J Nutr Biochem. 106:1090032022. View Article : Google Scholar : PubMed/NCBI | |
|
Kaushal JB, Bhatia R, Kanchan RK, Raut P, Mallapragada S, Ly QP, Batra SK and Rachagani S: Repurposing niclosamide for targeting pancreatic cancer by inhibiting Hh/Gli Non-canonical axis of Gsk3β. Cancers (Basel). 13:31052021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Wen B, Wang Y, Wu S, Zhang X, Gu Y, Wang Z, Wang J, Zhang W and Yong J: Jervine exhibits anticancer effects on nasopharyngeal carcinoma through promoting autophagic apoptosis via the blockage of Hedgehog signaling. Biomed Pharmacother. 132:1108982020. View Article : Google Scholar : PubMed/NCBI | |
|
Bissey PA, Mathot P, Guix C, Jasmin M, Goddard I, Costechareyre C, Gadot N, Delcros JG, Mali SM, Fasan R, et al: Blocking SHH/patched interaction triggers tumor growth inhibition through patched-induced apoptosis. Cancer Res. 80:1970–1980. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Delloye-Bourgeois C, Gibert B, Rama N, Delcros JG, Gadot N, Scoazec JY, Krauss R, Bernet A and Mehlen P: Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol. 11:e10016232013. View Article : Google Scholar : PubMed/NCBI | |
|
Kabarriti R and Guha C: Hedgehog signaling and radiation induced liver injury: A delicate balance. Hepatol Int. 8:316–320. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Gan GN, Eagles J, Keysar SB, Wang G, Glogowska MJ, Altunbas C, Anderson RT, Le PN, Morton JJ, Frederick B, et al: Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers. Cancer Res. 74:7024–7036. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Z, Huang C, Li R, Li H, Lu H and Lin Z: PRKCI Mediates radiosensitivity via the Hedgehog/GLI1 pathway in cervical cancer. Front Oncol. 12:8871392022. View Article : Google Scholar : PubMed/NCBI | |
|
Sims-Mourtada J, Izzo JG, Apisarnthanarax S, Wu TT, Malhotra U, Luthra R, Liao Z, Komaki R, van der Kogel A, Ajani J and Chao KS: Hedgehog: An attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res. 12:6565–6572. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Metge BJ, Alsheikh HA, Chen D, Elhamamsy AR, Hinshaw DC, Chen BR, Sleckman BP, Samant RS and Shevde LA: Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy. NPJ Precis Oncol. 7:612023. View Article : Google Scholar : PubMed/NCBI | |
|
Al-Azab M, Wang B, Elkhider A, Walana W, Li W, Yuan B, Ye Y, Tang Y, Almoiliqy M, Adlat S, et al: Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. Aging (Albany NY). 12:5693–5715. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Domen A, Deben C, Verswyvel J, Flieswasser T, Prenen H, Peeters M, Lardon F and Wouters A: Cellular senescence in cancer: clinical detection and prognostic implications. J Exp Clin Cancer Res. 41:3602022. View Article : Google Scholar : PubMed/NCBI | |
|
Tamayo-Orrego L, Wu CL, Bouchard N, Khedher A, Swikert SM, Remke M, Skowron P, Taylor MD and Charron F: Evasion of cell senescence leads to medulloblastoma progression. Cell Rep. 14:2925–2937. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Tu K, Wang Y, Yao B, Li Q, Wang L, Dou C, Liu Q and Zheng X: Hypoxia accelerates aggressiveness of hepatocellular carcinoma cells involving oxidative stress, epithelial-mesenchymal transition and non-canonical hedgehog signaling. Cell Physiol Biochem. 44:1856–1868. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wei M, Ma R, Huang S, Liao Y, Ding Y, Li Z, Guo Q, Tan R, Zhang L and Zhao L: Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia. J Cell Physiol. 234:17392–17404. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Xu QH, Xiao Y, Li XQ, Fan L, Zhou CC, Cheng L, Jiang ZD and Wang GH: Resveratrol counteracts Hypoxia-Induced gastric cancer invasion and EMT through hedgehog pathway suppression. Anticancer Agents Med Chem. 20:1105–1114. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, et al: Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 73:3235–3247. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Wu K, Gao D, Zhu G, Wu D, Wang X, Chen Y, Du Y, Song W, Ma Z, et al: Reciprocal regulation of hypoxia-inducible factor 2α and GLI1 expression associated with the radioresistance of renal cell carcinoma. Int J Radiat Oncol Biol Phys. 90:942–951. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xu M, Wang J, Li H, Zhang Z and Cheng Z: AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1. Aging (Albany NY). 13:1017–1031. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yin L, Cao R, Liu Z, Luo G, Li Y, Zhou X, Chen X, Wu Y, He J, Zu X and Shen Y: FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway. Acta Biochim Biophys Sin (Shanghai). 55:1770–1783. 2023.PubMed/NCBI | |
|
Sriramulu S, Sun XF, Malayaperumal S, Ganesan H, Zhang H, Ramachandran M, Banerjee A and Pathak S: Emerging role and clinicopathological significance of AEG-1 in different cancer types: A concise review. Cells. 10:14972021. View Article : Google Scholar : PubMed/NCBI | |
|
Inaguma S, Riku M, Ito H, Tsunoda T, Ikeda H and Kasai K: GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells. Oncotarget. 6:33648–33657. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lu JT, Zhao WD, He W and Wei W: Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin. 33:691–700. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MDC, Pineda-Villegas P, González-López MA, Ortiz-Quintero B, Mendoza-Milla C, Zatarain-Barrón ZL, et al: Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer. Eur J Cancer. 160:189–205. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Harada K, Ohashi R, Naito K and Kanki K: Hedgehog signal inhibitor GANT61 inhibits the malignant behavior of undifferentiated hepatocellular carcinoma cells by targeting Non-Canonical GLI signaling. Int J Mol Sci. 21:31262020. View Article : Google Scholar : PubMed/NCBI | |
|
Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F and Ruiz i Altaba A: Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA. 104:5895–5900. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Zhou X, Yang J, Sun Q, Liu Y, Li N, Zhang Z and Xu H: Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61. Cell Death Dis. 11:5962020. View Article : Google Scholar : PubMed/NCBI | |
|
Wasson CW, Caballero-Ruiz B, Gillespie J, Derrett-Smith E, Mankouri J, Denton CP, Canettieri G, Riobo-Del Galdo NA and Del Galdo F: Induction of Pro-Fibrotic CLIC4 in dermal fibroblasts by TGF-β/Wnt3a is mediated by GLI2 upregulation. Cells. 11:5302022. View Article : Google Scholar : PubMed/NCBI | |
|
You X, Wu J, Wang Y, Liu Q, Cheng Z, Zhao X, Liu G, Huang C, Dai J, Zhou Y, et al: Galectin-1 promotes vasculogenic mimicry in gastric adenocarcinoma via the Hedgehog/GLI signaling pathway. Aging (Albany NY). 12:21837–21853. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Guo E, Liu H and Liu X: Overexpression of SCUBE2 Inhibits proliferation, migration, and invasion in glioma cells. Oncol Res. 25:437–444. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Gialmanidis IP, Bravou V, Amanetopoulou SG, Varakis J, Kourea H and Papadaki H: Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas. Lung Cancer. 66:64–74. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Xu X, Su B, Xie C, Wei S, Zhou Y, Liu H, Dai W, Cheng P, Wang F, Xu X and Guo C: Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells. PLoS One. 9:e964412014. View Article : Google Scholar : PubMed/NCBI | |
|
Joost S, Almada LL, Rohnalter V, Holz PS, Vrabel AM, Fernandez-Barrena MG, McWilliams RR, Krause M, Fernandez-Zapico ME and Lauth M: GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res. 72:88–99. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K and Lo HW: Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Oncogene. 37:2502–2514. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, et al: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. 39:64–78. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Fan YH, Ding J, Nguyen S, Liu XJ, Xu G, Zhou HY, Duan NN, Yang SM, Zern MA and Wu J: Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells. Oncogene. 35:116–124. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, Arrigo A, Manore SG, Wagner C, Thomas A, et al: Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases. Cancer Lett. 540:2157262022. View Article : Google Scholar : PubMed/NCBI | |
|
Doheny D, Manore S, Sirkisoon SR, Zhu D, Aguayo NR, Harrison A, Najjar M, Anguelov M, Cox AO, Furdui CM, et al: An FDA-Approved antifungal, ketoconazole, and its novel derivative suppress tGLI1-Mediated breast cancer brain metastasis by inhibiting the DNA-Binding activity of brain metastasis-promoting transcription factor tGLI1. Cancers (Basel). 14:42562022. View Article : Google Scholar : PubMed/NCBI | |
|
Cao X, Geradts J, Dewhirst MW and Lo HW: Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene. 31:104–115. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Di Mauro C, Rosa R, D'Amato V, Ciciola P, Servetto A, Marciano R, Orsini RC, Formisano L, De Falco S, Cicatiello V, et al: Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers. Br J Cancer. 116:1425–1435. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bausch D, Fritz S, Bolm L, Wellner UF, Fernandez-Del-Castillo C, Warshaw AL, Thayer SP and Liss AS: Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer. Angiogenesis. 23:479–492. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Maiti S, Mondal S, Satyavarapu EM and Mandal C: mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation. Cell Death Dis. 8:e29262017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, et al: The crosstalk of mTOR/S6K1 and hedgehog pathways. Cancer Cell. 21:374–387. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Yan T, Guo W, Niu J, Zhao Z, Sun K, Zhang H, Yu Y and Ren T: Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. Cell Death Differ. 28:2221–2237. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Youssef M, Moussa N, W Helmy M and Haroun M: Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality. Med Oncol. 39:1432022. View Article : Google Scholar : PubMed/NCBI | |
|
Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, et al: Hedgehog-Interacting protein is a multimodal antagonist of hedgehog signalling. Nat Commun. 12:71712021. View Article : Google Scholar : PubMed/NCBI | |
|
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, et al: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 25:735–747. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Johar D, Elmehrath AO, Khalil RM, Elberry MH, Zaky S, Shalabi SA and Bernstein LH: Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism. Biofactors. 47:713–728. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wu J, Di D, Zhao C, Pan Q, Liu Y, Zhang X, Zhao X and Chen H: Clinical significance of Gli-1 And Caveolin-1 expression in the human small cell lung cancer. Asian Pac J Cancer Prev. 19:401–406. 2018.PubMed/NCBI | |
|
Di Magno L, Manzi D, D'Amico D, Coni S, Macone A, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Screpanti I, et al: Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth. Cell Cycle. 13:3404–3413. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, et al: Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer. 128:844–856. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Su J, Xie Q and Xie L: Identification and validation of a metabolism-related gene signature for predicting the prognosis of paediatric medulloblastoma. Sci Rep. 14:75402024. View Article : Google Scholar : PubMed/NCBI | |
|
D'Amico D, Antonucci L, Di Magno L, Coni S, Sdruscia G, Macone A, Miele E, Infante P, Di Marcotullio L, De Smaele E, et al: Non-canonical Hedgehog/AMPK-Mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth. Dev Cell. 35:21–35. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Luo J, Gong L, Yang Y, Zhang Y, Liu Q, Bai L, Fang X, Zhang B, Huang J, Liu M, et al: Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC. Hepatology. 79:61–78. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Deng S, Gu H, Chen Z, Liu Y, Zhang Q, Chen D and Yi S: PTCH1 mutation as a potential predictive biomarker for immune checkpoint inhibitors in gastrointestinal cancer. Carcinogenesis. 45:351–357. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, et al: A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma. Neuro Oncol. 21:1150–1163. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Pandey S, Lee M, Lim J, Park S, Choung YH, Kim JE, Garg P and Chung JH: SMO-CRISPR-mediated apoptosis in CD133-targeted cancer stem cells and tumor growth inhibition. J Control Release. 357:94–108. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Thazhackavayal Baby B, Kulkarni AM, Gayam PKR, Harikumar KB and Aranjani JM: Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention. Arch Biochem Biophys. 754:1099522024. View Article : Google Scholar : PubMed/NCBI | |
|
Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, et al: Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nat Med. 24:271–281. 2018. View Article : Google Scholar : PubMed/NCBI |
