Role of LMO7 in cancer (Review)
- Authors:
- Qun Zeng
- Tingting Jiang
- Jing Wang
-
Affiliations: Hunan Key Laboratory of The Research and Development of Novel Pharmaceutical Preparations, The Hunan Provincial University Key Laboratory of The Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, Hunan 410000, P.R. China - Published online on: July 11, 2024 https://doi.org/10.3892/or.2024.8776
- Article Number: 117
-
Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
de Visser KE and Joyce JA: The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 41:374–403. 2023. View Article : Google Scholar : PubMed/NCBI | |
Feinberg AP and Levchenko A: Epigenetics as a mediator of plasticity in cancer. Science. 379:eaaw38352023. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Chen G, Zhang Y, Ghareeb WM, Yu Q, Zhu H, Lu X, Huang Y, Huang S, Hou D and Chi P: The impact of circumferential tumour location on the clinical outcome of rectal cancer patients managed with neoadjuvant chemoradiotherapy followed by total mesorectal excision. Eur J Surg Oncol. 46:1118–1123. 2020. View Article : Google Scholar : PubMed/NCBI | |
Diori Karidio I and Sanlier SH: Reviewing cancer's biology: An eclectic approach. J Egypt Natl Canc Inst. 33:322021. View Article : Google Scholar : PubMed/NCBI | |
Zeng Q and Jiang T: The role of FHL1 in tumors. Gene. 11:1483472024. View Article : Google Scholar : PubMed/NCBI | |
Dietlein F, Wang AB, Fagre C, Tang A, Besselink NJM, Cuppen E, Li C, Sunyaev SR, Neal JT and Van Allen EM: Genome-wide analysis of somatic noncoding mutation patterns in cancer. Science. 376:eabg56012022. View Article : Google Scholar : PubMed/NCBI | |
Lou Z, Gong YQ, Zhou X and Hu GH: Low expression of miR-199 in hepatocellular carcinoma contributes to tumor cell hyper-proliferation by negatively suppressing XBP1. Oncol Lett. 16:6531–6539. 2018.PubMed/NCBI | |
Li L, Wang S and Zhou W: Balance cell apoptosis and pyroptosis of caspase-3-activating chemotherapy for better antitumor therapy. Cancers (Basel). 15:262022. View Article : Google Scholar : PubMed/NCBI | |
Du TT, Dewey JB, Wagner EL, Cui R, Heo J, Park JJ, Francis SP, Perez-Reyes E, Guillot SJ, Sherman NE, et al: LMO7 deficiency reveals the significance of the cuticular plate for hearing function. Nat Commun. 10:11172019. View Article : Google Scholar : PubMed/NCBI | |
Huang W, Xu Q, Su J, Tang L, Hao ZZ, Xu C, Liu R, Shen Y, Sang X, Xu N, et al: Linking transcriptomes with morphological and functional phenotypes in mammalian retinal ganglion cells. Cell Rep. 40:1113222022. View Article : Google Scholar : PubMed/NCBI | |
Mull A, Kim G and Holaska JM: LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy. Muscle Nerve. 51:222–228. 2015. View Article : Google Scholar : PubMed/NCBI | |
Possidonio AC, Soares CP, Fontenele M, Morris ER, Mouly V, Costa ML and Mermelstein C: Knockdown of Lmo7 inhibits chick myogenesis. FEBS Lett. 590:317–329. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gomes G, do Amaral MJ, Bagri KM, Vasconcellos LM, Almeida MDS, Alvares LE and Mermelstein C: New findings on LMO7 transcripts, proteins and regulatory regions in human and vertebrate model organisms and the intracellular distribution in skeletal muscle cells. Int J Mol Sci. 22:128852021. View Article : Google Scholar : PubMed/NCBI | |
She M, Tang M, Jiang T and Zeng Q: The roles of the LIM domain proteins in Drosophila cardiac and hematopoietic morphogenesis. Front Cardiovasc Med. 8:6168512021. View Article : Google Scholar : PubMed/NCBI | |
She M, Zhang J, Jiang T, Zhang Y, Liu Y, Tang M and Zeng Q: The function of Lmpt in Drosophila heart tissue. Biochem Biophys Res Commun. 612:15–21. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, She M, Dai Y, Nie X, Tang M and Zeng Q: Lmpt regulates the function of Drosophila muscle by acting as a repressor of Wnt signaling. Gene. 876:1475142023. View Article : Google Scholar : PubMed/NCBI | |
Sánta A, Czajlik A, Batta G, Péterfia B and Gáspári Z: Resonance assignment of the Shank1 PDZ domain. Biomol NMR Assign. 16:121–127. 2022. View Article : Google Scholar : PubMed/NCBI | |
Mieszczanek J, Strutt H, Rutherford TJ, Strutt D, Bienz M and Gammons MV: Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling. J Cell Sci. 135:jcs2595472022. View Article : Google Scholar : PubMed/NCBI | |
Palani S, Ghosh S, Ivorra-Molla E, Clarke S, Suchenko A, Balasubramanian MK and Köster DV: Calponin-homology domain mediated bending of membrane-associated actin filaments. Elife. 10:e610782021. View Article : Google Scholar : PubMed/NCBI | |
Mei L, Reynolds MJ, Garbett D, Gong R, Meyer T and Alushin GM: Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc Natl Acad Sci USA. 119:e22053701192022. View Article : Google Scholar : PubMed/NCBI | |
Ecke M, Prassler J and Gerisch G: Expanding ring-shaped cleavage furrows in multinucleate cells. Mol Biol Cell. 34:ar272023. View Article : Google Scholar : PubMed/NCBI | |
Cuadrado M and Robles-Valero J: VAV proteins as double agents in cancer: Oncogenes with tumor suppressor roles. Biology (Basel). 10:8882021.PubMed/NCBI | |
Guérin A, Roy NH, Kugler EM, Berry L, Burkhardt JK, Shin JB and Striepen B: Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7. Cell Host Microbe. 29:1407–1420.e5. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li M, An Z, Tang Q, Ma Y, Yan J, Chen S and Wang Y: Mixed responses to first-line alectinib in non-small cell lung cancer patients with rare ALK gene fusions: A case series and literature review. J Cell Mol Med. 25:9476–9481. 2021. View Article : Google Scholar : PubMed/NCBI | |
Hariyanto NI, Yo EC and Wanandi SI: Regulation and signaling of TGF-β autoinduction. Int J Mol Cell Med. 10:234–247. 2021.PubMed/NCBI | |
Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI | |
Xia H, Chen D, Wu Q, Wu G, Zhou Y, Zhang Y and Zhang L: CELF1 preferentially binds to exon-intron boundary and regulates alternative splicing in HeLa cells. Biochim Biophys Acta Gene Regul Mech. 1860:911–921. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45((W1)): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI | |
Miano JM, Long X and Fujiwara K: Serum response factor: Master regulator of the actin cytoskeleton and contractile apparatus. Am J Physiol Cell Physiol. 292:C70–C81. 2007. View Article : Google Scholar : PubMed/NCBI | |
Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E and Treisman R: Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol. 11:257–268. 2009. View Article : Google Scholar : PubMed/NCBI | |
Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C and Beckerle MC: The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell. 18:1723–1733. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kim D, Jung SH and Chung YJ: Development of an RNA sequencing panel to detect gene fusions in thyroid cancer. Genomics Inform. 19:e412021. View Article : Google Scholar : PubMed/NCBI | |
He H, Li W, Yan P, Bundschuh R, Killian JA, Labanowska J, Brock P, Shen R, Heerema NA and de la Chapelle A: Identification of a recurrent LMO7-BRAF fusion in papillary thyroid carcinoma. Thyroid. 28:748–754. 2018. View Article : Google Scholar : PubMed/NCBI | |
Oyinlade O, Wei S, Kammers K, Liu S, Wang S, Ma D, Huang ZY, Qian J, Zhu H, Wan J and Xia S: Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter-enhancer interactions. Epigenetics. 13:751–768. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tanaka-Okamoto M, Hori K, Ishizaki H, Hosoi A, Itoh Y, Wei M, Wanibuchi H, Mizoguchi A, Nakamura H and Miyoshi J: Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7. Cancer Sci. 100:608–616. 2009. View Article : Google Scholar : PubMed/NCBI | |
Nakamura H, Hori K, Tanaka-Okamoto M, Higashiyama M, Itoh Y, Inoue M, Morinaka S and Miyoshi J: Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma. Exp Ther Med. 2:1053–1057. 2011. View Article : Google Scholar : PubMed/NCBI | |
Karlsson T, Kvarnbrink S, Holmlund C, Botling J, Micke P, Henriksson R, Johansson M and Hedman H: LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease. Lung Cancer. 125:174–184. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wu H, Zhou J, Mei S, Wu D, Mu Z, Chen B, Xie Y, Ye Y and Liu J: Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7. J Cell Mol Med. 21:1228–1236. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ren B, Cui M, Yang G, Wang H, Feng M, You L and Zhao Y: Tumor microenvironment participates in metastasis of pancreatic cancer. Mol Cancer. 17:1082018. View Article : Google Scholar : PubMed/NCBI | |
Bayard Q, Caruso S, Couchy G, Rebouissou S, Bioulac Sage P, Balabaud C, Paradis V, Sturm N, de Muret A, Guettier C, et al: Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas. Gut. 69:1667–1676. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu X, Yuan H, Zhou J, Wang Q, Qi X, Bernal C, Avella D, Kaifi JT, Kimchi ET, Timothy P, et al: LMO7 as an unrecognized factor promoting pancreatic cancer progression and metastasis. Front Cell Dev Biol. 9:6473872021. View Article : Google Scholar : PubMed/NCBI | |
Davuluri RV, Suzuki Y, Sugano S, Plass C and Huang TH: The functional consequences of alternative promoter use in mammalian genomes. Trends Genet. 24:167–177. 2008. View Article : Google Scholar : PubMed/NCBI | |
Inchingolo MA, Diman A, Adamczewski M, Humphreys T, Jaquier-Gubler P and Curran JA: TP53BP1, a dual-coding gene, uses promoter switching and translational reinitiation to express a smORF protein. iScience. 26:1067572023. View Article : Google Scholar : PubMed/NCBI | |
Thorsen K, Schepeler T, Øster B, Rasmussen MH, Vang S, Wang K, Hansen KQ, Lamy P, Pedersen JS, Eller A, et al: Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis. BMC Genomics. 12:5052011. View Article : Google Scholar : PubMed/NCBI | |
Furuya M, Tsuji N, Endoh T, Moriai R, Kobayashi D, Yagihashi A and Watanabe N: A novel gene containing PDZ and LIM domains, PCD1, is overexpressed in human colorectal cancer. Anticancer Res. 22:4183–4186. 2002.PubMed/NCBI | |
Kang S, Xu H, Duan X, Liu JJ, He Z, Yu F, Zhou S, Meng XQ, Cao M and Kennedy GC: PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers. Cancer Res. 60:5296–5302. 2000.PubMed/NCBI | |
Jiang ZR, Yang LH, Jin LZ, Yi LM, Bing PP, Zhou J and Yang JS: Identification of novel cuproptosis-related lncRNA signatures to predict the prognosis and immune microenvironment of breast cancer patients. Front Oncol. 12:9886802022. View Article : Google Scholar : PubMed/NCBI | |
Bao Z, Zeng W, Zhang D, Wang L, Deng X, Lai J, Li J, Gong J and Xiang G: SNAIL induces EMT and lung metastasis of tumours secreting CXCL2 to promote the invasion of M2-type immunosuppressed macrophages in colorectal cancer. Int J Biol Sci. 18:2867–2881. 2022. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Chen L, Hua J and Song W: Long-term dynamic compression enhancement TGF-β3-induced chondrogenesis in bovine stem cells: A gene expression analysis. BMC Genom Data. 22:132021. View Article : Google Scholar : PubMed/NCBI | |
Hu Q, Guo C, Li Y, Aronow BJ and Zhang J: LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration. Mol Cell Biol. 31:3223–3240. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sun L, Zhang H and Gao P: Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell. 13:877–919. 2022. View Article : Google Scholar : PubMed/NCBI | |
He B, Dai C, Lang J, Bing P, Tian G, Wang B and Yang J: A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation. Biochim Biophys Acta Mol Basis Dis. 1866:1659162020. View Article : Google Scholar : PubMed/NCBI | |
Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, et al: LMO7 is a negative feedback regulator of transforming growth factor β signaling and fibrosis. Circulation. 139:679–693. 2019. View Article : Google Scholar : PubMed/NCBI | |
Kim M and Moon A: A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells. Toxicol Res. 38:19–26. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Qiang P, Yu J, Miao Y, Chen Z, Qu J, Zhao Q, Chen Z, Liu Y, Yao X, et al: Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 15:391–406. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chen ZK, Chen DZ, Cai C, Jin LL, Xu J, Tu YL, Huang XZ, Xu JL, Chen MZ, Xue FB, et al: BMSCs attenuate hepatic fibrosis in autoimmune hepatitis through regulation of LMO7-AP1-TGFβ signaling pathway. Eur Rev Med Pharmacol Sci. 25:1600–1611. 2021.PubMed/NCBI | |
Lim JW, Kim H and Kim KH: Cell adhesion-related gene expression by Helicobacter pylori in gastric epithelial AGS cells. Int J Biochem Cell Biol. 35:1284–1296. 2003. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Liu Q, Cui M, Wang M, Hua S, Gao J and Liao Q: Comprehensive analysis of expression, prognostic value, and immune infiltration for ubiquitination-related FBXOs in pancreatic ductal adenocarcinoma. Front Immunol. 12:7744352022. View Article : Google Scholar : PubMed/NCBI | |
Stefansson K, Oda H, Öfverman C, Lundin E, Hedman H and Lindquist D: LRIG1-2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV-DNA and p16INK4a status. Oncol Rep. 42:142–150. 2019.PubMed/NCBI | |
Zheng H, Li BH, Liu C, Jia L and Liu FT: Comprehensive analysis of lncRNA-mediated ceRNA crosstalk and identification of prognostic biomarkers in Wilms' tumor. Biomed Res Int. 2020:49516922020.PubMed/NCBI | |
A J, Zhang B, Zhang Z, Hu H and Dong JT: Novel gene signatures predictive of patient recurrence-free survival and castration resistance in prostate cancer. Cancers (Basel). 13:9172021. View Article : Google Scholar : PubMed/NCBI | |
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI | |
Mao X, Chen Y, Lu X, Jin S, Jiang P, Deng Z, Zhu X, Cai Q, Wu C and Kang S: Tissue resident memory T cells are enriched and dysfunctional in effusion of patients with malignant tumor. J Cancer. 14:1223–1231. 2023. View Article : Google Scholar : PubMed/NCBI | |
Huang A and Zhou W: Mn-based cGAS-STING activation for tumor therapy. Chin J Cancer Res. 35:19–43. 2023. View Article : Google Scholar : PubMed/NCBI | |
Feng S, Song G, Liu L, Liu W, Liang G and Song Z: Allergen-specific immunotherapy induces monocyte-derived dendritic cells but attenuates their maturation and cytokine production in the lesional skin of an atopic dermatitis mouse model. J Dermatol. 49:1310–1319. 2022. View Article : Google Scholar : PubMed/NCBI | |
Guo Z, Wang YJ, He BS and Zhou J: Linc00312 single nucleotide polymorphism as biomarker for chemoradiotherapy induced hematotoxicity in nasopharyngeal carcinoma patients. Dis Markers. 2022:67078212022. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Yang T, Shi S, Xu C, Wang F, Dai D, Guan G, Zhang Y, Wang S, Wang J, et al: Heterogeneity-induced NGF-NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti-tumor immunotherapy with PD-1 mAb in hepatocellular carcinoma. Cancer Med. 13:e67362024. View Article : Google Scholar : PubMed/NCBI | |
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
Fu S, Duan L, Zhong Y and Zeng Y: Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta-analysis. Int Wound J. 21:e144492023. View Article : Google Scholar : PubMed/NCBI | |
Lee B, Lee S, Lee Y, Park Y and Shim J: Emerin represses STAT3 signaling through nuclear membrane-based spatial control. Int J Mol Sci. 22:66692021. View Article : Google Scholar : PubMed/NCBI | |
Wu KY, Xie H, Zhang ZL, Li ZX, Shi L, Zhou W, Zeng J, Tian Z, Zhang Y, Ding YB and Shen WG: Emerin knockdown induces the migration and invasion of hepatocellular carcinoma cells by up-regulating the cytoplasmic p21. Neoplasma. 69:59–70. 2022. View Article : Google Scholar : PubMed/NCBI | |
Awotoye W, Mossey PA, Hetmanski JB, Gowans LJJ, Eshete MA, Adeyemo WL, Alade A, Zeng E, Adamson O, James O, et al: Damaging mutations in AFDN contribute to risk of nonsyndromic cleft lip with or without cleft palate. Cleft Palate Craniofac J. 61:697–705. 2024. View Article : Google Scholar : PubMed/NCBI | |
Berg HE, Greipp PT, Baughn LB, Falcon CP, Jackson CC and Peterson JF: Detection of a cryptic KMT2A/AFDN gene fusion [ins(6;11)(q27;q23q23)] in a pediatric patient with newly diagnosed acute myeloid leukemia. Lab Med. 53:e95–e99. 2022. View Article : Google Scholar : PubMed/NCBI | |
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, et al: Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A. Proc Natl Acad Sci USA. 117:26340–26346. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chen Q, Zhou XW, Zhang AJ and He K: ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma. J Exp Clin Cancer Res. 40:232021. View Article : Google Scholar : PubMed/NCBI | |
Wang R, Gao Y and Zhang H: ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma. Iran J Basic Med Sci. 26:200–207. 2023.PubMed/NCBI | |
Chen Q, Wang H, Li Z, Li F, Liang L, Zou Y, Shen H, Li J, Xia Y, Cheng Z, et al: Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. J Hepatol. 76:135–147. 2022. View Article : Google Scholar : PubMed/NCBI | |
Tentler D, Lomert E, Novitskaya K and Barlev NA: Role of ACTN4 in tumorigenesis, metastasis, and EMT. Cells. 8:14272019. View Article : Google Scholar : PubMed/NCBI | |
Singla A, Chen Q, Suzuki K, Song J, Fedoseienko A, Wijers M, Lopez A, Billadeau DD, van de Sluis B and Burstein E: Regulation of murine copper homeostasis by members of the COMMD protein family. Dis Model Mech. 14:dmm0459632021. View Article : Google Scholar : PubMed/NCBI | |
Iwuchukwu I, Nguyen D, Beavers M, Tran V, Sulaiman W, Fannin E, Lasseigne L, Ramsay E, Wilson J and Bazan NG: MicroRNA regulatory network as biomarkers of late seizure in patients with spontaneous intracerebral hemorrhage. Mol Neurobiol. 57:2346–2357. 2020. View Article : Google Scholar : PubMed/NCBI | |
Neveu B, Richer C, Cassart P, Caron M, Jimenez-Cortes C, St-Onge P, Fuchs C, Garnier N, Gobeil S and Sinnett D: Identification of new ETV6 modulators through a high-throughput functional screening. iScience. 25:1038582022. View Article : Google Scholar : PubMed/NCBI | |
da Silva AN, Ibelli AMG, Savoldi IR, Cantão ME, Zanella EL, Marques MG, da Silva MVGB, de Peixoto JO, Ledur MC, Lopes JS, et al: Whole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs. Sex Dev. 17:56–66. 2023. View Article : Google Scholar : PubMed/NCBI | |
Barcelo J and Sanz-Moreno V: NECTIN1 is a melanoma metastasis suppressor gene. Nat Genet. 54:1776–1777. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ablain J, Al Mahi A, Rothschild H, Prasad M, Aires S, Yang S, Dokukin ME, Xu S, Dang M, Sokolov I, et al: Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 54:1839–1852. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ho DW, Tsui YM, Chan LK, Sze KM, Zhang X, Cheu JW, Chiu YT, Lee JM, Chan AC, Cheung ET, et al: Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma. Nat Commun. 12:36842021. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Jiang C, Su Y, Gui J, Yue Z, Jian B, He S and Ma X: Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma. Acta Biochim Biophys Sin (Shanghai). 55:356–366. 2023. View Article : Google Scholar : PubMed/NCBI | |
Bhave S, Guyer RA, Picard N, Omer M, Hotta R and Goldstein AM: Ednrb−/− mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine. Front Cell Dev Biol. 10:9172432022. View Article : Google Scholar : PubMed/NCBI | |
Zheng Z, Gao M, Tang C, Huang L, Gong Y, Liu Y and Wang J: E. coli JM83 damages the mucosal barrier in Ednrb knockout mice to promote the development of Hirschsprung-associated enterocolitis via activation of TLR4/p-p38/NF-κB signaling. Mol Med Rep. 25:1682022. View Article : Google Scholar : PubMed/NCBI | |
Geng B, Wang X, Park KH, Lee KE, Kim J, Chen P, Zhou X, Tan T, Yang C, Zou X, et al: UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway. Redox Biol. 52:1022952022. View Article : Google Scholar : PubMed/NCBI | |
Mondal M, Conole D, Nautiyal J and Tate EW: UCHL1 as a novel target in breast cancer: Emerging insights from cell and chemical biology. Br J Cancer. 126:24–33. 2022. View Article : Google Scholar : PubMed/NCBI | |
Tang J, Yang Q, Mao C, Xiao D, Liu S, Xiao L, Zhou L, Wu G and Tao Y: The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway. Cell Death Differ. 30:1247–1259. 2023. View Article : Google Scholar : PubMed/NCBI | |
He R, Zhou Y, Liu J, Zhang X, Zhao X, An L, Li Z and Cheng F: UCHL3 plays an important role in the occurrence and development of melanoma. Oncol Lett. 22:7562021. View Article : Google Scholar : PubMed/NCBI | |
Thompson LL, Rutherford KA, Lepage CC and McManus KJ: Aberrant SKP1 expression: Diverse mechanisms impacting genome and chromosome stability. Front Cell Dev Biol. 10:8595822022. View Article : Google Scholar : PubMed/NCBI | |
Biryukov M, Dmitrieva A, Vavilova V, Ustyantsev K, Bazarova E, Sukhikh I, Berezikov E and Blinov A: Mlig-SKP1 gene is required for spermatogenesis in the flatworm macrostomum lignano. Int J Mol Sci. 23:151102022. View Article : Google Scholar : PubMed/NCBI | |
Engeland K: Cell cycle regulation: p53-p21-RB signaling. Cell Death Differ. 29:946–960. 2022. View Article : Google Scholar : PubMed/NCBI | |
Salaroglio IC, Belisario DC, Bironzo P, Ananthanarayanan P, Ricci L, Digiovanni S, Fontana S, Napoli F, Sandri A, Facolmatà C, et al: SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma. J Exp Clin Cancer Res. 41:752022. View Article : Google Scholar : PubMed/NCBI | |
Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, et al: CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 137:661–677. 2021. View Article : Google Scholar : PubMed/NCBI | |
Jia L and Sun Y: RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. Cell Div. 4:162009. View Article : Google Scholar : PubMed/NCBI | |
Bays JL and DeMali KA: Vinculin in cell-cell and cell-matrix adhesions. Cell Mol Life Sci. 74:2999–3009. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shih YT, Wei SY, Chen JH, Wang WL, Wu HY, Wang MC, Lin CY, Lee PL, Lin CY, Chiang HC, et al: Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis. Eur Heart J. 44:304–318. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yang W, Li J, Zhang M, Yu H, Zhuang Y, Zhao L, Ren L, Gong J, Bi H, Zeng L, et al: Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription. J Exp Clin Cancer Res. 41:672022. View Article : Google Scholar : PubMed/NCBI | |
Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, et al: Mutational landscape of gray zone lymphoma. Blood. 137:1765–1776. 2021. View Article : Google Scholar : PubMed/NCBI | |
Qie S: The E3 ubiquitin ligase fbxo4 functions as a tumor suppressor: Its biological importance and therapeutic perspectives. Cancers (Basel). 14:21332022. View Article : Google Scholar : PubMed/NCBI | |
Mucha B, Qie S, Bajpai S, Tarallo V, Diehl JN, Tedeschi F, Zhou G, Gao Z, Flashner S, Klein-Szanto AJ, et al: Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation. Nat Commun. 13:66142022. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Piao Y, Zhang D, Feng W, Wang C, Cui X, Ren Q, Zhu X and Zheng G: Fbxw11 impairs the repopulation capacity of hematopoietic stem/progenitor cells. Stem Cell Res Ther. 13:2452022. View Article : Google Scholar : PubMed/NCBI | |
Chen C, Zhou H, Zhang X, Liu Z and Ma X: Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma. Cancer Biomark. 35:429–437. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zou C, Chen Y, Smith RM, Snavely C, Li J, Coon TA, Chen BB, Zhao Y and Mallampalli RK: SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. J Biol Chem. 288:6306–6316. 2013. View Article : Google Scholar : PubMed/NCBI | |
De La Chesnaye E, Méndez JP, López-Romero R, De Los Angeles Romero-Tlalolini M, Vergara MD, Salcedo M and Ojeda SR: FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. Int J Clin Exp Pathol. 8:10192–10203. 2015.PubMed/NCBI | |
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, et al: Inhibition of the CDK2 and cyclin A complex leads to autophagic degradation of CDK2 in cancer cells. Nat Commun. 13:28352022. View Article : Google Scholar : PubMed/NCBI | |
Arora M, Moser J, Hoffman TE, Watts LP, Min M, Musteanu M, Rong Y, Ill CR, Nangia V, Schneider J, et al: Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity. Cell. 186:2628–2643.e21. 2023. View Article : Google Scholar : PubMed/NCBI |