![Open Access](/resources/images/iconopenaccess.png)
Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations (Review)
- Authors:
- Nilgun Tuncel Cini
- Manuela Pennisi
- Sidika Genc
- Demetrios A. Spandidos
- Luca Falzone
- Panayiotis D. Mitsias
- Aristides Tsatsakis
- Ali Taghizadehghalehjoughi
-
Affiliations: Department of Anatomy, Faculty of Medicine, Bilecik Şeyh Edebali University, Bilecik 11230, Turkey, Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy, Department of Pharmacology, Faculty of Medicine, Bilecik Şeyh Edebali University, Bilecik 11230, Turkey, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Neurology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece - Published online on: August 16, 2024 https://doi.org/10.3892/or.2024.8798
- Article Number: 139
-
Copyright: © Cini et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
![]() |
![]() |
Bouget D, Eijgelaar RS, Pedersen A, Kommers I, Ardon H, Barkhof F, Bello L, Berger MS, Nibali MC, Furtner J, et al: Glioblastoma surgery imaging-reporting and data system: Validation and performance of the automated segmentation task. Cancers (Basel). 13:46742021. View Article : Google Scholar : PubMed/NCBI | |
Fontán-Lozano Á, Morcuende S, Davis-López de Carrizosa MA, Benítez-Temiño B, Mejías R and Matarredona ER: To Become or not to become tumorigenic: Subventricular zone versus hippocampal neural stem cells. Front Oncol. 10:6022172020. View Article : Google Scholar : PubMed/NCBI | |
Xu H, Chen X, Sun Y, Hu X, Zhang X, Wang Y, Tang Q, Zhu Q, Song K, Chen H, et al: Comprehensive molecular characterization of long-term glioblastoma survivors. Cancer Lett. 593:2169382024. View Article : Google Scholar : PubMed/NCBI | |
Taghizadehghalehjoughi A, Hacımüftüoglu A, Cetin M, Ugur AB, Galatenau B, Mezhuev Y, Okkay U, Taspinar N, Taspinar M, Uyanik A, et al: Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: In vitro and in vivo studies. Nanomedicine. 13:1595–1606. 2018. View Article : Google Scholar : PubMed/NCBI | |
Grochans S, Cybulska AM, Simińska D, Korbecki J, Kojder K, Chlubek D and Baranowska-Bosiacka I: Epidemiology of glioblastoma multiforme-literature review. Cancers (Basel). 14:24122022. View Article : Google Scholar : PubMed/NCBI | |
Seker-Polat F, Pinarbasi Degirmenci N, Solaroglu I and Bagci-Onder T: Tumor cell infiltration into the brain in glioblastoma: From mechanisms to clinical perspectives. Cancers (Basel). 14:4432022. View Article : Google Scholar : PubMed/NCBI | |
Pittella JEH: The uniqueness of the human brain: A review. Dement Neuropsychol. 18:e202300782024. View Article : Google Scholar : PubMed/NCBI | |
Bisiacchi P and Cainelli E: Structural and functional brain asymmetries in the early phases of life: A scoping review. Brain Struct Funct. 227:479–496. 2022. View Article : Google Scholar : PubMed/NCBI | |
Spaccavento S, Caliendo S, Galetta R, Picciola E, Losavio E and Glueckauf R: Pragmatic communication deficit and functional outcome in patients with right- and left-brain damage: A pilot study. Brain Sci. 14:3872024. View Article : Google Scholar : PubMed/NCBI | |
Catani M: The anatomy of the human frontal lobe. Handb Clin Neurol. 163:95–122. 2019. View Article : Google Scholar : PubMed/NCBI | |
Goldberg E, Podell K and Lovell M: Lateralization of frontal lobe functions and cognitive novelty. J Neuropsychiatry Clin Neurosci. 6:371–378. 1994. View Article : Google Scholar : PubMed/NCBI | |
Wu Y, Wang J, Zhang Y, Zheng D, Zhang J, Rong M, Wu H, Wang Y, Zhou K and Jiang T: The neuroanatomical basis for posterior superior parietal lobule control lateralization of visuospatial attention. Front Neuroanat. 10:322016. View Article : Google Scholar : PubMed/NCBI | |
Dziedzic TA, Bala A and Marchel A: Cortical and subcortical anatomy of the parietal lobe from the neurosurgical perspective. Front Neurol. 12:7270552021. View Article : Google Scholar : PubMed/NCBI | |
Jeong SK and Xu Y: The impact of top-down spatial attention on laterality and hemispheric asymmetry in the human parietal cortex. J Vis. 16:22016. View Article : Google Scholar : PubMed/NCBI | |
Kondo M: The laterality of parietal association areas: Hemispatial neglect, body images and body schema. Brain Nerve. 70:1059–1066. 2018.(In Japanese). PubMed/NCBI | |
Rehman A and Al Khalili Y: Neuroanatomy, Occipital Lobe. StatPearls Treasure Island, FL: StatPearls Publishing; 2023, Available from:. https://www.ncbi.nlm.nih.gov/books/NBK544320/ | |
Vonk JMJ, Borghesani V, Battistella G, Younes K, DeLeon J, Welch A, Hubbard HI, Miller ZA, Miller BL and Gorno-Tempini ML: Verbal semantics and the left dorsolateral anterior temporal lobe: A longitudinal case of bilateral temporal degeneration. Aphasiology. 34:865–885. 2020. View Article : Google Scholar : PubMed/NCBI | |
Kuo F and Massoud TF: Structural asymmetries in normal brain anatomy: A brief overview. Ann Anat. 241:1518942022. View Article : Google Scholar : PubMed/NCBI | |
Zhao F, Wu Z, Wang L, Lin W and Li G: Longitudinally consistent registration and parcellation of cortical surfaces using semi-supervised learning. Med Image Anal. 96:1031932024. View Article : Google Scholar : PubMed/NCBI | |
Kong XZ, Mathias SR, Guadalupe T; ENIGMA Laterality Working Group, ; Glahn DC, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher SE, Thompson PM, et al: Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci USA. 115:E5154–E5163. 2018. View Article : Google Scholar : PubMed/NCBI | |
Fu L, Wang Y, Fang H, Xiao X, Xiao T, Li Y, Li C, Wu Q, Chu K, Xiao C and Ke X: Longitudinal study of brain asymmetries in autism and developmental delays Aged 2–5 years. Neuroscience. 432:137–149. 2020. View Article : Google Scholar : PubMed/NCBI | |
Koelkebeck K, Miyata J, Kubota M, Kohl W, Son S, Fukuyama H, Sawamoto N, Takahashi H and Murai T: The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain. Hum Brain Mapp. 35:6011–6022. 2014. View Article : Google Scholar : PubMed/NCBI | |
Esteves M, Ganz E, Sousa N and Leite-Almeida H: Asymmetrical brain plasticity: Physiology and pathology. Neuroscience. 454:3–14. 2021. View Article : Google Scholar : PubMed/NCBI | |
Grant JH, Parker AJ, Hodgson JC, Hudson JM and Bishop DVM: Testing the relationship between lateralization on sequence-based motor tasks and language laterality using an online battery. Laterality. 28:1–31. 2023. View Article : Google Scholar : PubMed/NCBI | |
Corballis MC: Evolution of cerebral asymmetry. Prog Brain Res. 250:153–178. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhai Z and Feng J: Left-right asymmetry influenced the infarct volume and neurological dysfunction following focal middle cerebral artery occlusion in rats. Brain Behav. 8:e011662018. View Article : Google Scholar : PubMed/NCBI | |
Edwards JD, Jacova C, Sepehry AA, Pratt B and Benavente OR: A quantitative systematic review of domain-specific cognitive impairment in lacunar stroke. Neurology. 80:315–322. 2013. View Article : Google Scholar : PubMed/NCBI | |
De Luca C, Virtuoso A, Papa M, Certo F, Barbagallo GMV and Altieri R: Regional development of Glioblastoma: The anatomical conundrum of cancer biology and its surgical implication. Cells. 11:13492022. View Article : Google Scholar : PubMed/NCBI | |
Nestler U, Lutz K, Pichlmeier U, Stummer W, Franz K, Reulen HJ and Bink A; 5-ALA Glioma Study Group, : Anatomic features of glioblastoma and their potential impact on survival. Acta Neurochir (Wien). 157:179–186. 2015. View Article : Google Scholar : PubMed/NCBI | |
Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Selker RG, Fine HA, Black PM, Loeffler JS, Shapiro WR and Linet MS: Laterality of brain tumors. Neuroepidemiology. 22:130–138. 2003. View Article : Google Scholar : PubMed/NCBI | |
Jansma JM and Rutten G: P04.11 effect of hemisphere and tumor grade on default mode deactivation in glioma patients. Neuro Onco. 19:iii422017. View Article : Google Scholar | |
Coluccia D, Roth T, Marbacher S and Fandino J: Impact of laterality on surgical outcome of glioblastoma patients: A retrospective single-center study. World Neurosurg. 114:e121–e128. 2018. View Article : Google Scholar : PubMed/NCBI | |
Mazoyer B, Zago L, Jobard G, Crivello F, Joliot M, Perchey G, Mellet E, Petit L and Tzourio-Mazoyer N: Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness. PLoS One. 9:e1011652014. View Article : Google Scholar : PubMed/NCBI | |
Noll KR, Ziu M, Weinberg JD and Wefel J: Neurocognitive functioning in patients with glioma of the left and right temporal lobes. J Neurooncol. 128:323–331. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ellingson BM, Lai A, Harris RJ, Selfridge JM, Yong WH, Das K, Pope WB, Nghiemphu PL, Vinters HV, Liau LM, et al: Probabilistic radiographic atlas of glioblastoma phenotypes. AJNR Am J Neuroradiol. 34:533–540. 2013. View Article : Google Scholar : PubMed/NCBI | |
Larjavaara S, Mäntylä R, Salminen T, Haapasalo H, Raitanen J, Jääskeläinen J and Auvinen A: Incidence of gliomas by anatomic location. Neuro Oncol. 9:319–325. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kommers I, Bouget D, Pedersen A, Eijgelaar RS, Ardon H, Barkhof F, Bello L, Berger MS, Conti Nibali M, Furtner J, et al: Glioblastoma surgery imaging-reporting and data system: Standardized reporting of tumor volume, location, and resectability based on automated segmentations. Cancers (Basel). 13:28542021. View Article : Google Scholar : PubMed/NCBI | |
Mickevicius NJ, Carle AB, Bluemel T, Santarriaga S, Schloemer F, Shumate D, Connelly J, Schmainda KM and LaViolette PS: Location of brain tumor intersecting white matter tracts predicts patient prognosis. J Neurooncol. 125:393–400. 2015. View Article : Google Scholar : PubMed/NCBI | |
Filippopulos FM, Brem C, Seelos K, Köglsperger T, Sonnenfeld S, Kellert L and Vollmar C: Uncrossed corticospinal tract in health and genetic disorders: Review, case report, and clinical implications. Eur J Neurol. 28:2804–2811. 2021. View Article : Google Scholar : PubMed/NCBI | |
Welniarz Q, Dusart I and Roze E: The corticospinal tract: Evolution, development, and human disorders. Devel Neurobio. 77:810–829. 2017. View Article : Google Scholar : PubMed/NCBI | |
Danks RA, Aglio LS, Gugino LD and Black PM: Craniotomy under local anesthesia and monitored conscious sedation for the resection of tumors involving eloquent cortex. J Neurooncol. 49:131–139. 2000. View Article : Google Scholar : PubMed/NCBI | |
Salvati M, Armocida D, Pesce A, Palmieri M, Venditti E, D'Andrea G, Frati A and Santoro A: No prognostic differences between GBM-patients presenting with postoperative SMA-syndrome and GBM-patients involving cortico-spinal tract and primary motor cortex. J Neurol Sci. 419:1171882020. View Article : Google Scholar : PubMed/NCBI | |
Frye RE, Hasan K, Malmberg B, Desouza L, Swank P, Smith K and Landry S: Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term. Dev Med Child Neurol. 52:760–766. 2010. View Article : Google Scholar : PubMed/NCBI | |
Nakajima R, Kinoshita M, Shinohara H and Nakada M: The superior longitudinal fascicle: Reconsidering the fronto-parietal neural network based on anatomy and function. Brain Imaging Behav. 14:2817–2830. 2020. View Article : Google Scholar : PubMed/NCBI | |
Makris N, Kennedy DN, McInerney S, Sorensen AG, Wang R, Caviness VS Jr and Pandya DN: Segmentation of subcomponents within the superior longitudinal fascicle in humans: A quantitative, in vivo, DT-MRI study. Cereb Cortex. 15:854–869. 2005. View Article : Google Scholar : PubMed/NCBI | |
Catani M and Thiebaut de Schotten M: Atlas of Human Brain Connections. Oxford; University Press: 2012, View Article : Google Scholar | |
Janelle F, Iorio-Morin C, D'Amour S and Fortin D: Superior longitudinal fasciculus: A review of the anatomical descriptions with functional correlates. Front Neurol. 13:7946182022. View Article : Google Scholar : PubMed/NCBI | |
Martino J, De Witt Hamer PC, Berger MS, Lawton MT, Arnold CM, de Lucas EM and Duffau H: Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: A fiber dissection and DTI tractography study. Brain Struct Funct. 218:105–121. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Pathak S, Stefaneanu L, Yeh FC, Li S and Fernandez-Miranda JC: Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain. Brain Struct Funct. 221:2075–2092. 2016. View Article : Google Scholar : PubMed/NCBI | |
Thiebaut de Schotten M, Dell'Acqua F, Forkel SJ, Simmons A, Vergani F, Murphy DG and Catani M: A lateralized brain network for visuospatial attention. Nat Neurosci. 14:1245–1246. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hecht EE, Gutman DA, Bradley BA, Preuss TM and Stout D: Virtual dissection and comparative connectivity of the superior longitudinal fasciculus in chimpanzees and humans. Neuroimage. 108:124–137. 2015. View Article : Google Scholar : PubMed/NCBI | |
Vernooij MW, Smits M, Wielopolski PA, Houston GC, Krestin GP and van der Lugt A: Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and lefthanded healthy subjects: A combined fMRI and DTI study. Neuroimage. 35:1064–1076. 2007. View Article : Google Scholar : PubMed/NCBI | |
Netter FH: Atlas of Human Anatomy. 6th edition. Elsevier; Philedelphia: 2008 | |
Davtian M, Ulmer JL, Mueller WM, Gaggl W, Mulane MP and Krouwer HG: The superior longitudinal fasciculus and speech arrest. J Comput Assist Tomogr. 32:410–414. 2008. View Article : Google Scholar : PubMed/NCBI | |
Nakajima R, Kinoshita M, Miyashita K, Okita H, Genda R, Yahata T, Hayashi Y and Nakada M: Damage of the right dorsal superior longitudinal fascicle by awake surgery for glioma causes persistent visuospatial dysfunction. Sci Rep. 7:171582017. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Liu Y, Hu X, Hu G, Yang K, Xiao C, Hu J, Li Z, Zou Y, Chen J, et al: Alterations of white matter integrity associated with cognitive deficits in patients with glioma. Brain Behav. 10:e016392020. View Article : Google Scholar : PubMed/NCBI | |
Tamai S, Kinoshita M, Nakajima R, Okita H and Nakada M: Two different subcortical language networks supporting distinct Japanese orthographies: Morphograms and phonograms. Brain Struct Funct. 227:1145–1154. 2022. View Article : Google Scholar : PubMed/NCBI | |
Latini F, Mårtensson J, Larsson EM, Fredrikson M, Åhs F, Hjortberg M, Aldskogius H and Ryttlefors M: Segmentation of the inferior longitudinal fasciculus in the human brain: A white matter dissection and diffusion tensor tractography study. Brain Res. 1675:102–115. 2017. View Article : Google Scholar : PubMed/NCBI | |
Duffau H: White matter tracts and diffuse Lower-grade gliomas: The pivotal role of myelin plasticity in the tumor pathogenesis, infiltration patterns, functional consequences and therapeutic management. Front Oncol. 12:8555872022. View Article : Google Scholar : PubMed/NCBI | |
Herbet G, Moritz-Gasser S, Boiseau M, Duvaux S, Cochereau J and Duffau H: Converging evidence for a cortico-subcortical network mediating lexical retrieval. Brain. 139:3007–3021. 2016. View Article : Google Scholar : PubMed/NCBI | |
DE Benedictis A, Marras CE, Petit L and Sarubbo S: The inferior Fronto-occipital fascicle: A century of controversies from anatomy theaters to operative neurosurgery. J Neurosurg Sci. 65:605–615. 2021.PubMed/NCBI | |
Vassal F, Pommier B, Sontheimer A and Lemaire JJ: Inter-individual variations and hemispheric asymmetries in structural connectivity patterns of the inferior Fronto-occipital fascicle: A diffusion tensor imaging tractography study. Surg Radiol Anat. 40:129–137. 2018. View Article : Google Scholar : PubMed/NCBI | |
Altieri R, Melcarne A, Junemann C, Zeppa P, Zenga F, Garbossa D, Certo F and Barbagallo G: Inferior Fronto-occipital fascicle anatomy in brain tumor surgeries: From anatomy lab to surgical theater. J Clin Neurosci. 68:290–294. 2019. View Article : Google Scholar : PubMed/NCBI | |
Camins À, Naval-Baudin P, Majós C, Sierpowska J, Sanmillan JL, Cos M, Rodriguez-Fornells A and Gabarrós A: Inferior Fronto-occipital fascicle displacement in temporoinsular gliomas using diffusion tensor imaging. J Neuroimaging. 32:638–646. 2022. View Article : Google Scholar : PubMed/NCBI | |
Heller C, Steinmann S, Levitt JJ, Makris N, Antshel KM, Fremont W, Coman IL, Schweinberger SR, Weiß T, Bouix S, et al: Abnormalities in white matter tracts in the Fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS. Schizophr Res. 224:141–150. 2020. View Article : Google Scholar : PubMed/NCBI | |
Levitt JJ, Zhang F, Vangel M, Nestor PG, Rathi Y, Kubicki M, Shenton ME and O'Donnell LJ: The organization of frontostriatal brain wiring in healthy subjects using a novel diffusion imaging fiber cluster analysis. Cereb Cortex. 31:5308–5318. 2021. View Article : Google Scholar : PubMed/NCBI | |
Kinoshita M, de Champfleur NM, Deverdun J, Moritz-Gasser S, Herbet G and Duffau H: Role of Fronto-striatal tract and frontal aslant tract in movement and speech: An axonal mapping study. Brain Struct Funct. 220:3399–3412. 2015. View Article : Google Scholar : PubMed/NCBI | |
La Corte E, Eldahaby D, Greco E, Aquino D, Bertolini G, Levi V, Ottenhausen M, Demichelis G, Romito LM, Acerbi F, et al: The frontal aslant tract: A systematic review for neurosurgical applications. Front Neurol. 12:6415862021. View Article : Google Scholar : PubMed/NCBI | |
Landers MJF, Meesters SPL, van Zandvoort M, de Baene W and Rutten GM: The frontal aslant tract and its role in executive functions: A quantitative tractography study in glioma patients. Brain Imaging Behav. 16:1026–1039. 2022. View Article : Google Scholar : PubMed/NCBI | |
Müller DMJ, Robe PAJT, Eijgelaar RS, Witte MG, Visser M, de Munck JC, Broekman MLD, Seute T, Hendrikse J, Noske DP, et al: Comparing Glioblastoma surgery decisions between teams using brain maps of tumor locations, biopsies, and resections. JCO Clin Cancer Inform. 3:1–12. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cancer Genome Atlas Research Network, . Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, et al: Comprehensive, integrative genomic analysis of diffuse Lower-grade gliomas. N Engl J Med. 372:2481–2498. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yabo YA, Niclou SP and Golebiewska A: Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma. Neuro Oncol. 24:669–682. 2022. View Article : Google Scholar : PubMed/NCBI | |
Qi S, Yu L, Li H, Ou Y, Qiu X, Ding Y, Han H and Zhang X: Isocitrate dehydrogenase mutation is associated with tumor location and magnetic resonance imaging characteristics in astrocytic neoplasms. Oncol Lett. 7:1895–1902. 2014. View Article : Google Scholar : PubMed/NCBI | |
Fathi Kazerooni A, Bakas S, Saligheh Rad H and Davatzikos C: Imaging signatures of glioblastoma molecular characteristics: A radiogenomics review. J Magn Reson Imaging. 52:54–69. 2020. View Article : Google Scholar : PubMed/NCBI | |
J Dabrowski M and Wojtas B: Global DNA methylation patterns in human gliomas and their interplay with other epigenetic modifications. Int J Mol Sci. 20:34782019. View Article : Google Scholar : PubMed/NCBI | |
Klughammer J, Kiesel B, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, et al: The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space. Nat Med. 24:1611–1624. 2018. View Article : Google Scholar : PubMed/NCBI | |
de Souza CF, Sabedot TS, Malta TM, Stetson L, Morozova O, Sokolov A, Laird PW, Wiznerowicz M, Iavarone A, Snyder J, et al: A Distinct DNA methylation shift in a subset of Glioma CpG island methylator phenotypes during tumor recurrence. Cell Rep. 23:637–651. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lucas CG, Mueller S, Reddy A, Taylor JW, Oberheim Bush NA, Clarke JL, Chang SM, Gupta N, Berger MS, Perry A, et al: Diffuse hemispheric glioma, H3 G34-mutant: Genomic landscape of a new tumor entity and prospects for targeted therapy. Neuro Oncol. 23:1974–1976. 2021. View Article : Google Scholar : PubMed/NCBI | |
Gatto L, Franceschi E, Tosoni A, Di Nunno V, Tonon C, Lodi R, Agati R, Bartolini S and Brandes AA: Beyond imaging and genetic signature in Glioblastoma: Radiogenomic holistic approach in Neuro-oncology. Biomedicines. 10:32052022. View Article : Google Scholar : PubMed/NCBI | |
Cui M, Gao X, Chi Y, Zhang M, Lin H, Chen H, Sun C and Ma X: Molecular alterations and their correlation with the survival of glioblastoma patients with corpus callosum involvement. Front Neurosci. 15:7014262021. View Article : Google Scholar : PubMed/NCBI | |
Kannan S, Murugan AK, Balasubramanian S, Munirajan AK and Alzahrani AS: Gliomas: Genetic alterations, mechanisms of metastasis, recurrence, drug resistance, and recent trends in molecular therapeutic options. Biochem Pharmacol. 201:1150902022. View Article : Google Scholar : PubMed/NCBI | |
El Atat O, Naser R, Abdelkhalek M, Habib RA and El Sibai M: Molecular targeted therapy: A new avenue in glioblastoma treatment. Oncol Lett. 25:462022. View Article : Google Scholar : PubMed/NCBI | |
Jiang H, Yu K, Cui Y, Ren X, Li M, Zhang G, Yang C, Zhao X, Zhu Q and Lin S: Differential predictors and clinical implications associated with long-term survivors in IDH Wildtype and mutant Glioblastoma. Front Oncol. 11:6326632021. View Article : Google Scholar : PubMed/NCBI | |
Senhaji N, Louati S, Chbani L, El Fatemi H, Hammas N, Mikou K, Maaroufi M, Benzagmout M, Boujraf S, El Bardai S, et al: EGFR amplification and IDH mutations in glioblastoma patients of the northeast of morocco. Biomed Res Int. 2017:80458592017. View Article : Google Scholar : PubMed/NCBI | |
Solomou G, Finch A, Asghar A and Bardella C. Mutant IDH in Gliomas: Role in cancer and treatment options. Cancers (Basel). 15:28832023. View Article : Google Scholar : PubMed/NCBI | |
Sharma N, Mallela AN, Shi DD, Tang LW, Abou-Al-Shaar H, Gersey ZC, Zhang X, McBrayer SK and Abdullah KG: Isocitrate dehydrogenase mutations in gliomas: A review of current understanding and trials. Neurooncol Adv. 5:vdad0532023.PubMed/NCBI | |
Kudulaiti N, Zhang H, Qiu T, Lu J, Aibaidula A, Zhang Z, Guan Y and Zhuang D: The Relationship between IDH1 mutation status and metabolic imaging in nonenhancing supratentorial diffuse gliomas: A 11C-MET PET study. Mol Imaging. 18:15360121198940872019. View Article : Google Scholar : PubMed/NCBI | |
Kopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau CA, Huguet G, Jean-Louis M, Martin CO, Saci Z, et al: Using rare genetic mutations to revisit structural brain asymmetry. bioRxiv. Apr 18–2023.(Epub ahead of print). doi: 10.1101/2023.04.17.537199. | |
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H and Cao L: Epidermal growth factor receptor in glioblastoma. Oncol Lett. 14:512–516. 2017. View Article : Google Scholar : PubMed/NCBI | |
Oprita A, Baloi SC, Staicu GA, Alexandru O, Tache DE, Danoiu S, Micu ES and Sevastre AS: Updated insights on EGFR signaling pathways in glioma. Int J Mol Sci. 22:5872021. View Article : Google Scholar : PubMed/NCBI | |
Ezzati S, Salib S, Balasubramaniam M and Aboud O: Epidermal growth factor receptor inhibitors in glioblastoma: Current status and future possibilities. Int J Mol Sci. 25:23162024. View Article : Google Scholar : PubMed/NCBI | |
Moghaddam M, Vivarelli S, Falzone L, Libra M and Bonavida B: Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: Therapeutic implications. Explor Target Antitumor Ther. 4:170–207. 2023. View Article : Google Scholar : PubMed/NCBI | |
Dogan E, Yildirim Z, Akalin T, Ozgiray E, Akinturk N, Aktan C, Solmaz AE, Biceroglu H, Caliskan KE, Ertan Y, et al: Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours. J Neurooncol. 166:283–292. 2024. View Article : Google Scholar : PubMed/NCBI | |
Della Monica R, Cuomo M, Buonaiuto M, Costabile D, Franca RA, Del Basso De Caro M, Catapano G, Chiariotti L and Visconti R: MGMT and Whole-genome DNA methylation impacts on diagnosis, prognosis and therapy of glioblastoma multiforme. Int J Mol Sci. 23:71482022. View Article : Google Scholar : PubMed/NCBI | |
Falzone L, Bordonaro R and Libra M: SnapShot: Cancer chemotherapy. Cell. 186:18162023. View Article : Google Scholar | |
Alnahhas I, Alsawas M, Rayi A, Palmer JD, Raval R, Ong S, Giglio P, Murad MH and Puduvalli V: Characterizing benefit from temozolomide in MGMT promoter unmethylated and methylated glioblastoma: A systematic review and meta-analysis. Neurooncol Adv. 2:vdaa0822020.PubMed/NCBI | |
Ellingson BM, Cloughesy TF, Pope WB, Zaw TM, Phillips H, Lalezari S, Nghiemphu PL, Ibrahim H, Naeini KM, Harris RJ, et al: Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas. Neuroimage. 59:908–916. 2012. View Article : Google Scholar : PubMed/NCBI | |
Li P, Ensink E, Lang S, Marshall L, Schilthuis M, Lamp J, Vega I and Labrie V: Hemispheric asymmetry in the human brain and in Parkinson's disease is linked to divergent epigenetic patterns in neurons. Genome Biol. 21:612020. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Dube C, Gibert M Jr, Cruickshanks N, Wang B, Coughlan M, Yang Y, Setiady I, Deveau C, Saoud K, et al: The p53 pathway in glioblastoma. Cancers (Basel). 10:2972018. View Article : Google Scholar : PubMed/NCBI | |
Wang YY, Zhang T, Li SW, Qian TY, Fan X, Peng XX, Ma J, Wang L and Jiang T: Mapping p53 mutations in low-grade glioma: A voxel-based neuroimaging analysis. AJNR Am J Neuroradiol. 36:70–76. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zhang T, Wang Y, Fan X, Ma J, Li S, Jiang T and Wang L: Anatomical localization of p53 mutated tumors: A radiographic study of human glioblastomas. J Neurol Sci. 346:94–98. 2014. View Article : Google Scholar : PubMed/NCBI | |
Marutani M, Tonoki H, Tada M, Takahashi M, Kashiwazaki H, Hida Y, Hamada J, Asaka M and Moriuchi T: Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme. Cancer Res. 59:4765–4769. 1999.PubMed/NCBI | |
Scheer M, Leisz S, Sorge E, Storozhuk O, Prell J, Ho I and Harder A: Neurofibromatosis type 1 gene alterations define specific features of a subset of glioblastomas. Int J Mol Sci. 23:3522021. View Article : Google Scholar : PubMed/NCBI | |
Costa AA and Gutmann DH: Brain tumors in neurofibromatosis type 1. Neurooncol Adv. 1:vdz0402019.PubMed/NCBI | |
Lobbous M, Bernstock JD, Coffee E, Friedman GK, Metrock LK, Chagoya G, Elsayed G, Nakano I, Hackney JR, Korf BR, et al: An update on neurofibromatosis type 1-associated gliomas. Cancers (Basel). 12:1142020. View Article : Google Scholar : PubMed/NCBI | |
Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M and Zen PRG: PDGFRA, KIT, and KDR gene amplification in glioblastoma: Heterogeneity and clinical significance. Neuromolecular Med. 25:441–450. 2023. View Article : Google Scholar : PubMed/NCBI | |
Hu W, Duan H, Zhong S, Zeng J and Mou Y: High frequency of PDGFRA and MUC family gene mutations in diffuse hemispheric glioma, H3 G34-mutant: A glimmer of hope? J Transl Med. 20:642022. View Article : Google Scholar : PubMed/NCBI | |
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR and Castro MG: Mutant ATRX: Uncovering a new therapeutic target for glioma. Expert Opin Ther Targets. 22:599–613. 2018. View Article : Google Scholar : PubMed/NCBI | |
Meng L, Zhang R, Fa L, Zhang L, Wang L and Shao G: ATRX status in patients with gliomas: Radiomics analysis. Medicine (Baltimore). 101:e301892022. View Article : Google Scholar : PubMed/NCBI | |
Silantyev AS, Falzone L, Libra M, Gurina OI, Kardashova KS, Nikolouzakis TK, Nosyrev AE, Sutton CW, Mitsias PD and Tsatsakis A: Current and future trends on diagnosis and prognosis of glioblastoma: From molecular biology to proteomics. Cells. 8:8632019. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Su X, Kemp GJ, Yang X, Wan X, Tan Q, Yue Q and Gong Q: Two patterns of white matter connection in multiple gliomas: Evidence from probabilistic fiber tracking. J Clin Med. 11:36932022. View Article : Google Scholar : PubMed/NCBI | |
Genc S, Pennisi M, Yeni Y, Yildirim S, Gattuso G, Altinoz MA, Taghizadehghalehjoughi A, Bolat I, Tsatsakis A, Hacımüftüoğlu A, et al: Potential neurotoxic effects of Glioblastoma-derived exosomes in primary cultures of cerebellar neurons via oxidant stress and glutathione depletion. Antioxidants (Basel). 11:12252022. View Article : Google Scholar : PubMed/NCBI | |
Yeni Y, Taghizadehghalehjoughi A, Genc S, Hacimüftüoglu A, Yıldırım S and Bolat I: Glioblastoma cell-derived exosomes induce cell death and oxidative stress in primary cultures of olfactory neurons. Role of redox stress. Mol Biol Rep. 50:3999–4009. 2023. View Article : Google Scholar : PubMed/NCBI | |
Stella M, Falzone L, Caponnetto A, Gattuso G, Barbagallo C, Battaglia R, Mirabella F, Broggi G, Altieri R, Certo F, et al: Serum extracellular Vesicle-derived circHIPK3 and circSMARCA5 Are two novel diagnostic biomarkers for glioblastoma multiforme. Pharmaceuticals (Basel). 14:6182021. View Article : Google Scholar : PubMed/NCBI | |
Candido S, Lupo G, Pennisi M, Basile MS, Anfuso CD, Petralia MC, Gattuso G, Vivarelli S, Spandidos DA, Libra M, et al: The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease. Oncol Rep. 42:911–922. 2019.PubMed/NCBI | |
Zeng F, Fan Z, Li S, Li L, Sun T, Qiu Y, Nie L and Huang G: Tumor microenvironment activated photoacoustic-fluorescence bimodal nanoprobe for precise Chemo-immunotherapy and immune response tracing of glioblastoma. ACS Nano. 17:19753–19766. 2023. View Article : Google Scholar : PubMed/NCBI | |
Peng Y, Liu Y, Lu X, Wang S, Chen M, Huang W, Wu Z, Lu G and Nie L: Ag-hybridized plasmonic Au-triangular nanoplates: Highly sensitive photoacoustic/Raman evaluation and improved antibacterial/photothermal combination therapy. J Mater Chem B. 6:2813–2820. 2018. View Article : Google Scholar : PubMed/NCBI | |
Valenzuela-Fuenzalida JJ, Moyano-Valarezo L, Silva-Bravo V, Milos-Brandenberg D, Orellana-Donoso M, Nova-Baeza P, Suazo-Santibáñez A, Rodríguez-Luengo M, Oyanedel-Amaro G, Sanchis-Gimeno J, et al: Association between the anatomical location of glioblastoma and its evaluation with clinical considerations: A systematic review and meta-analysis. J Clin Med. 13:34602024. View Article : Google Scholar : PubMed/NCBI |