Open Access

Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review)

  • Authors:
    • Qiang Yi
    • Gangfeng Zhu
    • Weijian Zhu
    • Jiaqi Wang
    • Xinting Ouyang
    • Kuan Yang
    • Jinghua Zhong
  • View Affiliations

  • Published online on: October 8, 2024     https://doi.org/10.3892/or.2024.8821
  • Article Number: 162
  • Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Collagen type X α1 chain (COL10A1), a gene encoding the α‑1 chain of type X collagen, serves a key role in conferring tensile strength and structural integrity to tissues. Upregulation of COL10A1 expression has been observed in different malignancies, including lung, gastric and pancreatic cancer, and is associated with poor prognosis. The present review provides an updated synthesis of the evolving biological understanding of COL10A1, with a particular focus on its mechanisms of action and regulatory functions within the context of tumorigenesis. For example, it has been established that increased COL10A1 expression promotes cancer progression by activating multiple signaling pathways, including the TGF‑β1/Smad, MEK/ERK and focal adhesion kinase signaling pathways, thereby inducing proliferation, invasion and migration. Additionally, COL10A1 has been demonstrated to induce epithelial‑mesenchymal transition and reshapes the extracellular matrix within tumor tissues. Furthermore, on the basis of methyltransferase‑like 3‑mediated N6‑methyladenosine methylation, COL10A1 intricately regulates the epitranscriptomic machinery, thereby augmenting its oncogenic role. However, although COL10A1 serves a pivotal role in gene transcription and the orchestration of tumor growth, the question of whether COL10A1 would serve as a viable therapeutic target remains a subject of scientific hypothesis requiring rigorous examination. Variables such as distinct tumor microenvironments and treatment associations necessitate further experimental validation. Therefore, a comprehensive assessment and understanding of the functional and mechanistic roles of COL10A1 in cancer may pave the way for the development of innovative cancer treatment strategies.
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December-2024
Volume 52 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yi Q, Zhu G, Zhu W, Wang J, Ouyang X, Yang K and Zhong J: Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review). Oncol Rep 52: 162, 2024.
APA
Yi, Q., Zhu, G., Zhu, W., Wang, J., Ouyang, X., Yang, K., & Zhong, J. (2024). Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review). Oncology Reports, 52, 162. https://doi.org/10.3892/or.2024.8821
MLA
Yi, Q., Zhu, G., Zhu, W., Wang, J., Ouyang, X., Yang, K., Zhong, J."Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review)". Oncology Reports 52.6 (2024): 162.
Chicago
Yi, Q., Zhu, G., Zhu, W., Wang, J., Ouyang, X., Yang, K., Zhong, J."Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review)". Oncology Reports 52, no. 6 (2024): 162. https://doi.org/10.3892/or.2024.8821