Open Access

Role of miRNA‑145‑5p in cancer (Review)

  • Authors:
    • Zeshan Chen
    • Yijue Qin
  • View Affiliations

  • Published online on: January 30, 2025     https://doi.org/10.3892/or.2025.8872
  • Article Number: 39
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA‑145‑5p (miRNA‑145‑5p) is a short non‑coding RNA located at chromosome 5q33.1, which has gained significant attention in several aspects of cellular regulation and biological functions. In malignant tumours, miRNA‑145‑5p may function as either a tumour suppressor or an oncogene, affecting tumour progression by targeting downstream genes or modulating their expression through upstream regulators. However, the full extent of miRNA‑145‑5p's role in cancer has remained to be determined. This review provides an overview of the role of miRNA‑145‑5p in cancer, investigates its potential as a biomarker for diagnosis, prognosis and treatment response, and evaluates its influence on cancer chemotherapy and radiotherapy. Finally, current strategies for systemic delivery of miRNA‑145‑5p in cancer therapies are summarized.
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March-2025
Volume 53 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Z and Qin Y: Role of miRNA‑145‑5p in cancer (Review). Oncol Rep 53: 39, 2025.
APA
Chen, Z., & Qin, Y. (2025). Role of miRNA‑145‑5p in cancer (Review). Oncology Reports, 53, 39. https://doi.org/10.3892/or.2025.8872
MLA
Chen, Z., Qin, Y."Role of miRNA‑145‑5p in cancer (Review)". Oncology Reports 53.3 (2025): 39.
Chicago
Chen, Z., Qin, Y."Role of miRNA‑145‑5p in cancer (Review)". Oncology Reports 53, no. 3 (2025): 39. https://doi.org/10.3892/or.2025.8872