Open Access

Mendelian randomization study of the association between cathepsins and melanoma

  • Authors:
    • Wenwen Wang
    • Jun Li
  • View Affiliations

  • Published online on: July 3, 2024     https://doi.org/10.3892/wasj.2024.262
  • Article Number: 47
  • Copyright : © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Malignant melanoma is a skin tumor with a poor prognosis. Therefore, it is critical to explore the risk factors associated with the outcome of this tumor. In the present study, Mendelian randomization (MR) was used to investigate the causal association between cathepsins and malignant melanoma. Summary statistical data on five cathepsins from European participants were extracted as exposure data. Data on melanoma from a genome‑wide association study of European ancestry were used as outcome data. Single nucleotide polymorphisms associated with cathepsins were used as instrumental variables (IVs). In a genome‑wide association study of malignant melanoma including 3,751 melanoma cases and 372,016 European ancestry controls, MR analysis was conducted to examine the effects of these IVs on melanoma. The inverse variance‑weighted method was used for MR analysis. In addition, MR‑Egger, weighted median and MR pleiotropy residual sum were used for complementary analyses. Furthermore, a series of sensitivity analyses were performed to ensure the validity and robustness of the results. The gene‑predicted results indicated no causal association between the five cathepsins and malignant melanoma (P>0.05). Cathepsin S [odds ratio (OR), 1.000; 95% confidence interval (CI), 0.999‑1.001; P=0.943], cathepsin B (OR, 1.000; 95% CI, 0.999‑1.001; P=0.763), cathepsin O (OR, 1.000; 95% CI, 0.999‑1.001; P=0.646), cathepsin E (OR, 0.999; 95% CI, 0.998‑1.001; P=0.375) and cathepsin L2 (OR, 1.101; 95% CI, 0.831‑1.458; P=0.503) were not significantly associated with the risk of developing melanoma. Sensitivity analysis demonstrated no significant bias in the aforementioned results. On the whole, in the present study, MR analysis did not provide evidence that cathepsins (cathepsin S, cathepsin B, cathepsin O, cathepsin E and cathepsin L2) are causally related to malignant melanoma.
View Figures
View References

Related Articles

Journal Cover

September-October 2024
Volume 6 Issue 5

Print ISSN: 2632-2900
Online ISSN:2632-2919

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang W and Li J: Mendelian randomization study of the association between cathepsins and melanoma. World Acad Sci J 6: 47, 2024.
APA
Wang, W., & Li, J. (2024). Mendelian randomization study of the association between cathepsins and melanoma. World Academy of Sciences Journal, 6, 47. https://doi.org/10.3892/wasj.2024.262
MLA
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6.5 (2024): 47.
Chicago
Wang, W., Li, J."Mendelian randomization study of the association between cathepsins and melanoma". World Academy of Sciences Journal 6, no. 5 (2024): 47. https://doi.org/10.3892/wasj.2024.262