search button
Open Access

Risk factors for mortality in patients with bacterial meningitis following a neurosurgical procedure: A meta‑analysis

  • Authors:
    • Wihasto Suryaningtyas
    • Rizki Meizikri
    • Muhammad Arifin Parenrengi
    • Budi Utomo
    • Asra Al Fauzi
    • Abdul Hafid Bajamal

  • View Affiliations

  • Published online on: August 21, 2024     https://doi.org/10.3892/wasj.2024.274
  • Article Number: 59

  • Copyright : © Suryaningtyas et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The treatment of post‑operative bacterial meningitis (POBM) poses challenges due to multiple factors, including a broader spectrum of pathogens, compromised neurological status or comorbidities at baseline, and concurrent conditions that can lead to delayed diagnosis. Studies examining risk factors for mortality in patients with POBM remain insufficient. The present study conducted a meta‑analysis investigating various determinants considered to affect the mortality rates of patients with POBM. The key factors examined included age, comorbidity, cerebrospinal fluid (CSF) lactate levels, CSF glucose levels, initial Glasgow coma scale (GCS) score and the presence of Gram‑negative bacteria. Relevant literature was identified through searches on the PubMed, Science Direct, The Cochrane Library, and the Directory of Open Access Journals databases. The present meta‑analysis adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses (PRISMA), employing specific inclusion criteria. A total of 82 publications met the inclusion criteria. The mortality rate due to POBM was found to be 28% [with a 95% confidence interval (CI) of 23‑32%]. The presence of comorbidity had a mortality risk ratio of 1.97 (with a 95% CI of 1.58‑2.46). The mean difference for age was 4.65 years (with a 95% CI of 1.78‑7.52). The pooled mean for CSF lactate was 52.88 mg/dl (with a 95% CI of 38.14‑67.62). The mean difference for CSF glucose was ‑13.55 (with a 95% CI of ‑20.95 to ‑6.15). The mean difference for GCS was ‑1.69 (with a 95% CI of ‑2.51 to ‑0.86). There was no significant difference in the mortality risk between those with Gram‑negative bacteria and those with Gram‑positive bacteria. On the whole, these outcomes suggest that among survivors and non‑survivors of POBM, there are no significant differences in age or initial GCS scores. However, the presence of comorbidities increases the risk of mortality, and non‑survivors of POBM have lower CSF glucose levels.
View Figures
View References

Related Articles

Journal Cover

November-December 2024
Volume 6 Issue 6

Print ISSN: 2632-2900
Online ISSN:2632-2919

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • CiteScore: 2.9
  • CiteScore Rank: Q2: #184/636 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.379
  • SCImago Journal Rank (SJR): 0.371
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Suryaningtyas W, Meizikri R, Parenrengi MA, Utomo B, Al Fauzi A and Bajamal AH: Risk factors for mortality in patients with bacterial meningitis following a neurosurgical procedure: A meta‑analysis. World Acad Sci J 6: 59, 2024.
APA
Suryaningtyas, W., Meizikri, R., Parenrengi, M.A., Utomo, B., Al Fauzi, A., & Bajamal, A.H. (2024). Risk factors for mortality in patients with bacterial meningitis following a neurosurgical procedure: A meta‑analysis. World Academy of Sciences Journal, 6, 59. https://doi.org/10.3892/wasj.2024.274
MLA
Suryaningtyas, W., Meizikri, R., Parenrengi, M. A., Utomo, B., Al Fauzi, A., Bajamal, A. H."Risk factors for mortality in patients with bacterial meningitis following a neurosurgical procedure: A meta‑analysis". World Academy of Sciences Journal 6.6 (2024): 59.
Chicago
Suryaningtyas, W., Meizikri, R., Parenrengi, M. A., Utomo, B., Al Fauzi, A., Bajamal, A. H."Risk factors for mortality in patients with bacterial meningitis following a neurosurgical procedure: A meta‑analysis". World Academy of Sciences Journal 6, no. 6 (2024): 59. https://doi.org/10.3892/wasj.2024.274