Open Access

Treatment and management of duodenal gangliocytic paraganglioma: A case report

  • Authors:
    • Na Xiao
    • Sumin Zhu
    • Huan Liu
    • Longfei Li
    • Lihong Shi
  • View Affiliations

  • Published online on: September 19, 2024     https://doi.org/10.3892/etm.2024.12723
  • Article Number: 435
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gangliocytic paraganglioma (GP) is a rare neuroendocrine tumor primarily found in the duodenum, most commonly in the second and third sections of the duodenum. Diagnosis of GP is based on its distinctive histopathological characteristics, which include three types of tumor cells in varying proportions: i) Epithelioid, ii) spindle‑like and iii) ganglion‑shaped cells. The distribution of the three tumor cell components varies from case to case and a patient may be easily misdiagnosed if one of the components is predominant. Endoscopic submucosal dissection (ESD) or surgical resection is the ideal treatment for duodenal GP (DGP); however, biotherapy, nuclide therapy, chemotherapy, targeted therapy and immunotherapy can be selected individually for patients with postoperative recurrence, metastasis or not suitable for surgery. In the present study, a male patient with DGP experienced recurrence after ESD surgery, and so received octreotide (Novartis; 30 mg/28 days) for 12 consecutive cycles. The patient had no further symptoms of gastrointestinal bleeding and no new lesions or metastases were observed after 47 months of follow‑up.
View Figures
View References

Related Articles

Journal Cover

December-2024
Volume 28 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiao N, Zhu S, Liu H, Li L and Shi L: Treatment and management of duodenal gangliocytic paraganglioma: A case report. Exp Ther Med 28: 435, 2024.
APA
Xiao, N., Zhu, S., Liu, H., Li, L., & Shi, L. (2024). Treatment and management of duodenal gangliocytic paraganglioma: A case report. Experimental and Therapeutic Medicine, 28, 435. https://doi.org/10.3892/etm.2024.12723
MLA
Xiao, N., Zhu, S., Liu, H., Li, L., Shi, L."Treatment and management of duodenal gangliocytic paraganglioma: A case report". Experimental and Therapeutic Medicine 28.6 (2024): 435.
Chicago
Xiao, N., Zhu, S., Liu, H., Li, L., Shi, L."Treatment and management of duodenal gangliocytic paraganglioma: A case report". Experimental and Therapeutic Medicine 28, no. 6 (2024): 435. https://doi.org/10.3892/etm.2024.12723