Open Access

Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review

  • Authors:
    • Lina Xing
    • Tian Tian
    • Yang Li
    • Jingnan Zhang
    • Xiaonan Guo
    • Shukai Qiao
  • View Affiliations

  • Published online on: July 23, 2024     https://doi.org/10.3892/ol.2024.14584
  • Article Number: 451
  • Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The occurrence of acute myeloid leukemia (AML) with a simultaneous diagnosis of breast cancer (BC) is rarely reported in the literature. The present study reports the case of a 50‑year‑old female patient diagnosed with AML coexisting with metastatic BC. Following one cycle of treatment with azacytidine in combination with oral venetoclax for AML, the patient achieved complete remission with incomplete hematological recovery. In addition, the mass in the left breast was smaller following adjuvant chemotherapy. However, due to a refusal from the patient to accept an allogeneic hematopoietic stem cell transplantation (allo‑HSCT), the patient succumbed 3 months after diagnosis due to septic shock from neutropenia following the third cycle of chemotherapy. Altogether, the present case report highlighted the application of venetoclax, an oral selective B‑cell lymphoma‑2 inhibitor, both in hematologic malignancies and solid neoplasms, as an effective therapeutic regimen. Considering the fatality rate associated with AML, allo‑HSCT is the only available strategy that can be used to achieve the long‑term survival of patients with AML and BC.
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October-2024
Volume 28 Issue 4

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Copy and paste a formatted citation
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Spandidos Publications style
Xing L, Tian T, Li Y, Zhang J, Guo X and Qiao S: Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review. Oncol Lett 28: 451, 2024.
APA
Xing, L., Tian, T., Li, Y., Zhang, J., Guo, X., & Qiao, S. (2024). Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review. Oncology Letters, 28, 451. https://doi.org/10.3892/ol.2024.14584
MLA
Xing, L., Tian, T., Li, Y., Zhang, J., Guo, X., Qiao, S."Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review". Oncology Letters 28.4 (2024): 451.
Chicago
Xing, L., Tian, T., Li, Y., Zhang, J., Guo, X., Qiao, S."Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review". Oncology Letters 28, no. 4 (2024): 451. https://doi.org/10.3892/ol.2024.14584