Open Access

Antioxidant, antidiabetic and antifungal activities of leaf and bark ethanol extracts of Mangifera indica and their antagonistic biochemical effects

  • Authors:
    • Mojisola Esther Karigidi
    • Oluwalonimi Ewaoluwa Fakunle
    • Kayode Olayele Karigidi
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  • Published online on: March 12, 2025     https://doi.org/10.3892/ijfn.2025.46
  • Article Number: 5
  • Copyright : © Karigidi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Mango (Mangifera indica L.), a member of the Anacardiaceae family, is one of the most economically significant tropical fruit crops worldwide. Both mango leaves and bark have been traditionally used for their medicinal properties. Locally, individuals tend to combine different parts of medicinal plants in an attempt to increase their therapeutic potency; however, the adverse effects of such combinations are mostly unreported. The present study investigated the biochemical activities and phytoconstituents of ethanol extracts from the leaves and bark of Mangifera indica individually and in combination. The antioxidant properties of these extracts were evaluated using various assays, including 2,2‑diphenyl‑l‑picrylhydrazyl, 2,2'‑azinobis(3‑ethylbenzothiazoline‑6‑sulphonic acid radical scavenging assays, ferric reducing antioxidant power assay and total antioxidant activity assay along with the analysis of total phenolic and flavonoid contents. The anti‑diabetic activity was evaluated through in vitro assays of α‑glucosidase and α‑amylase inhibition and antifungal properties were assessed against the fungal pathogen, Fusarium solani. Gas chromatography‑mass spectrometry analysis revealed numerous bioactive compounds, such as phenols, sesquiterpenes, terpenoids, fatty acids and esters. The results demonstrated marked antioxidant, anti‑diabetic and antifungal activities which were highest in the bark extract. However, combining the bark with leaf extract of Mangifera indica was antagonistic as the biochemical activities were significantly reduced.
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January-December 2025
Volume 6 Issue 1

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Spandidos Publications style
Karigidi ME, Fakunle OE and Karigidi KO: Antioxidant, antidiabetic and antifungal activities of leaf and bark ethanol extracts of <em>Mangifera indica</em> and their antagonistic biochemical effects. Int J Funct Nutr 6: 5, 2025.
APA
Karigidi, M.E., Fakunle, O.E., & Karigidi, K.O. (2025). Antioxidant, antidiabetic and antifungal activities of leaf and bark ethanol extracts of <em>Mangifera indica</em> and their antagonistic biochemical effects. International Journal of Functional Nutrition, 6, 5. https://doi.org/10.3892/ijfn.2025.46
MLA
Karigidi, M. E., Fakunle, O. E., Karigidi, K. O."Antioxidant, antidiabetic and antifungal activities of leaf and bark ethanol extracts of <em>Mangifera indica</em> and their antagonistic biochemical effects". International Journal of Functional Nutrition 6.1 (2025): 5.
Chicago
Karigidi, M. E., Fakunle, O. E., Karigidi, K. O."Antioxidant, antidiabetic and antifungal activities of leaf and bark ethanol extracts of <em>Mangifera indica</em> and their antagonistic biochemical effects". International Journal of Functional Nutrition 6, no. 1 (2025): 5. https://doi.org/10.3892/ijfn.2025.46