Journal Articles
Review
IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)
Xinxin Long, Yingnan Ye, Lijie Zhang, Pengpeng Liu, Wenwen Yu, Feng Wei, Xiubao Ren, Jinpu Yu
Pages: 5-12 Published online on: 06 November 2015
Review
Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)
Ralph Zinner, Carla Visseren-Grul, David R. Spigel, Coleman Obasaju
Pages: 13-27 Published online on: 29 October 2015
Article
Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells
Chiara Di Nisio, Silvia Sancilio, Viviana Di Giacomo, Monica Rapino, Laura Sancillo, Domenico Genovesi, Alessandro Di Siena, Rosa Alba Rana, Amelia Cataldi, Roberta Di Pietro
Pages: 28-36 Published online on: 09 November 2015
Article
Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells
Ryosuke Horie, Osamu Nakamura, Yoshiki Yamagami, Masaki Mori, Hideki Nishimura, Natsuko Fukuoka, Tetsuji Yamamoto
Pages: 37-44 Published online on: 03 November 2015
Article
Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines
Shuntaro Mukai, Shota Moriya, Masaki Hiramoto, Hiromi Kazama, Hiroko Kokuba, Xiao-Fang Che, Tomohisa Yokoyama, Satoshi Sakamoto, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Ōmura, Hiroshi Handa, Takao Itoi, Keisuke Miyazawa
Pages: 45-54 Published online on: 09 November 2015
Article
Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma
Jakub Klacz, Piotr M. Wierzbicki, Agata Wronska, Agnieszka Rybarczyk, Marcin Stanislawowski, Tomasz Slebioda, Agata Olejniczak, Marcin Matuszewski, Zbigniew Kmiec
Pages: 55-66 Published online on: 18 November 2015
Article
Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines
Ningning He, Nayoung Kim, Euna Jeong, Yiling Lu, Gordon B. Mills, Sukjoon Yoon
Pages: 67-72 Published online on: 11 November 2015
Article
Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells
Fatima H. Mohammed, Maitham A. Khajah, Ming Yang, William J. Brackenbury, Yunus A. Luqmani
Pages: 73-83 Published online on: 09 November 2015
Article
Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma
Raj Kumar Mongre, Simrinder Singh Sodhi, Neelesh Sharma, Mrinmoy Ghosh, Jeong Hyun Kim, Nameun Kim, Yang Ho Park, Young Gyu Shin, Sung Jin Kim, Zhang Jiao Jiao, Do Luong Huynh, Dong Kee Jeong
Pages: 84-98 Published online on: 13 November 2015
Article
CD44v3+/CD24- cells possess cancer stem cell-like properties in human oral squamous cell carcinoma
Keita Todoroki, Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Yoshiki Naito, Naoko Seki, Jingo Kusukawa, Hirohisa Yano
Pages: 99-109 Published online on: 20 November 2015
Article
FH535 suppresses the proliferation and motility of hepatocellular carcinoma cells
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Pages: 110-114 Published online on: 29 October 2015
Article
Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base
Hidekazu Takahashi, Yozo Suzuki, Junichi Nishimura, Naotsugu Haraguchi, Masahisa Ohtsuka, Susumu Miyazaki, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Pages: 115-122 Published online on: 20 November 2015
Article
Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Pages: 123-129 Published online on: 20 November 2015
Article
Transcriptome sequencing of human breast cancer reveals aberrant intronic transcription in amplicons and dysregulation of alternative splicing with major therapeutic implications
Shiva Seyed Forootan, Joe M. Butler, Derek Gardener, Alison E. Baird, Andrew Dodson, Alistair Darby, John Kenny, Neil Hall, Andrew R. Cossins, Christopher S. Foster, Christine M. Gosden
Pages: 130-144 Published online on: 30 October 2015
Article
A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients
Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Masaki Mori, Yuichiro Doki, Hideshi Ishii
Pages: 145-152 Published online on: 20 November 2015
Article
Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling
Zhuo Deng, Lijie Wang, Huilian Hou, Jiancheng Zhou, Xu Li
Pages: 153-160 Published online on: 04 November 2015
Article
miR-21: A gene of dual regulation in breast cancer
Chunfu Zhang, Kui Liu, Tao Li, Jie Fang, Yanling Ding, Lingxian Sun, Tao Tu, Xinyi Jiang, Shanmei Du, Jiabo Hu, Wei Zhu, Huabiao Chen, Xiaochun Sun
Pages: 161-172 Published online on: 05 November 2015
Article
Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase
Alan Wei-Shun Tseng, Victoria Akerstrom, Chiachen Chen, Mary B. Breslin, Michael S. Lan
Pages: 173-180 Published online on: 30 October 2015
Article
miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer
Hong Tan, Qingnan He, Guanhui Gong, Yixuan Wang, Juanni Li, Junpu Wang, Ding Zhu, Xiaoying Wu
Pages: 181-190 Published online on: 09 November 2015
Article
The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells
Katja Storch, Nils Cordes
Pages: 191-198 Published online on: 13 November 2015
Article
TIPE2 functions as a metastasis suppressor via negatively regulating β-catenin through activating GSK3β in gastric cancer
Jie Wu, Haitao Zhang, Chun Xu, Hong Xu, Xiumin Zhou, Yufeng Xie, Min Tao
Pages: 199-206 Published online on: 30 October 2015
Article
IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation
Rui-Li Zhang, Li-Xia Peng, Jun-Ping Yang, Li-Sheng Zheng, Ping Xie, Meng-Yao Wang, Bi-Jun Huang, Hua-Rong Zhao, Yong-Xing Bao, Chao-Nan Qian
Pages: 207-214 Published online on: 02 November 2015
Article
Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer
Jun Han, Qingyang Meng, Qiulei Xi, Yongxian Zhang, Qiulin Zhuang, Yusong Han, Yi Jiang, Qiurong Ding, Guohao Wu
Pages: 215-224 Published online on: 02 November 2015
Article
NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression
Yi Sun, Zhenfeng Guan, Liang Liang, Yongyi Cheng, Jiancheng Zhou, Jing Li, Yonggang Xu
Pages: 225-234 Published online on: 20 November 2015
Article
Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth
Yoshinobu Saitoh, Takao Setoguchi, Masahito Nagata, Arisa Tsuru, Shunsuke Nakamura, Satoshi Nagano, Yasuhiro Ishidou, Hiroko Nagao-Kitamoto, Masahiro Yokouchi, Shingo Maeda, Akihide Tanimoto, Tatsuhiko Furukawa, Setsuro Komiya
Pages: 235-242 Published online on: 06 November 2015
Article
Downregulation of transient receptor potential cation channel, subfamily C, member 1 contributes to drug resistance and high histological grade in ovarian cancer
Xia Liu, Jing Zou, Jie Su, Yi Lu, Jian Zhang, Li Li, Fuqiang Yin
Pages: 243-252 Published online on: 19 November 2015
Article
PF-04691502, a dual PI3K/mTOR inhibitor has potent pre-clinical activity by inducing apoptosis and G1 cell cycle arrest in aggressive B-cell non-Hodgkin lymphomas
Deyu Chen, Chaoming Mao, Yuepeng Zhou, Yuting Su, Shenzha Liu, Wen-Qing Qi
Pages: 253-260 Published online on: 05 November 2015
Article
Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells
Cheol Park, Ji-Suk Jeong, Jin-Woo Jeong, Yong-Joo Kim, Yeon-Kwon Jung, Geun-Bae Go, Sung Ok Kim, Gi-Young Kim, Su-Hyun Hong, Young Hyun Yoo, Yung Hyun Choi
Pages: 261-270 Published online on: 05 November 2015
Article
CA IX is upregulated in CoCl2-induced hypoxia and associated with cell invasive potential and a poor prognosis of breast cancer
Cheng-Yu Chu, Yi-Ting Jin, Wei Zhang, Juan Yu, Hai-Ping Yang, Hong-Ying Wang, Zi-Jing Zhang, Xiu-Ping Liu, Qiang Zou
Pages: 271-280 Published online on: 19 November 2015
Article
Theaflavin-3, 3'-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways
Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen
Pages: 281-292 Published online on: 20 November 2015
Article
Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma
Zenpei Shigemi, Yoshiki Furukawa, Kohei Hosokawa, Setsuya Minami, Jumpei Matsuhiro, Shiori Nakata, Tadashi Watanabe, Hiroki Kagawa, Koji Nakagawa, Hiroshi Takeda, Masahiro Fujimuro
Pages: 293-304 Published online on: 17 November 2015
Article
Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway
Mitsuru Chiba, Narumi Watanabe, Miki Watanabe, Maki Sakamoto, Akika Sato, Mizuki Fujisaki, Shiori Kubota, Satoru Monzen, Atsushi Maruyama, Naoki Nanashima, Ikuo Kashiwakura, Toshiya Nakamura
Pages: 305-312 Published online on: 19 November 2015
Article
3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation
Iris Eke, Stephanie Hehlgans, Veit Sandfort, Nils Cordes
Pages: 313-321 Published online on: 04 November 2015
Article
The antipsychotic drug pimozide inhibits cell growth in prostate cancer through suppression of STAT3 activation
Wei Zhou, Ming-Kun Chen, Hao-Tao Yu, Zhi-Hong Zhong, Nan Cai, Guan-Zhong Chen, Ping Zhang, Jia-Jie Chen
Pages: 322-328 Published online on: 04 November 2015
Article
Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma
Juan Gao, Yimin Xiong, Yan Wang, Yiming Wang, Guorong Zheng, Hualin Xu
Pages: 329-337 Published online on: 30 October 2015
Article
The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway
Ji Qin Gai, Xia Sheng, Jian Min Qin, Kang Sun, Wei Zhao, Lei Ni
Pages: 338-348 Published online on: 18 November 2015
Article
All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro
Jiejie Cui, Mengjia Gong, Yun He, Qilin Li, Tongchuan He, Yang Bi
Pages: 349-357 Published online on: 06 November 2015
Article
Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression
Yan Duan, Winnie Wong, Sonja Courtney Chua, Hwee Lin Wee, Seng Gee Lim, Boon Tin Chua, Han Kiat Ho
Pages: 358-366 Published online on: 13 November 2015
Article
Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer
Nayoung Kim, Mee Song, Somin Kim, Yujeong Seo, Yonghwan Kim, Sukjoon Yoon
Pages: 367-375 Published online on: 20 November 2015
Article
Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells
Ji Hoon Jang, Joo-Young Kim, Eon-Gi Sung, Eun-Ae Kim, Tae-Jin Lee
Pages: 376-384 Published online on: 18 November 2015
Article
A novel curcumin derivative increases the cytotoxicity of raloxifene in estrogen receptor-negative breast cancer cell lines
Sebastien Taurin, Mhairi Nimick, Lesley Larsen, Rhonda J. Rosengren
Pages: 385-398 Published online on: 19 November 2015
Article
Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
Yoon-Mi Lee, Gibok Lee, Taek-In Oh, Byeong Mo Kim, Do-Wan Shim, Kwang-Ho Lee, Young Jun Kim, Beong Ou Lim, Ji-Hong Lim
Pages: 399-408 Published online on: 11 November 2015
Article
Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines
Md. Ali Asgar, Gulsiri Senawong, Banchob Sripa, Thanaset Senawong
Pages: 409-420 Published online on: 09 November 2015
Article
